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Items: 1 to 20 of 42

1.
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Jr, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen
Nat Commun. 2024; 15: 2635. Published online 2024 Mar 25. doi: 10.1038/s41467-024-46953-x
PMCID:
PMC10963788
AbstractArticlePDF–7.6M
2.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
3.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma
De-Chen Yu, Xiang-Yi Chen, Xin Li, Hai-Yu Zhou, De-Quan Yu, Xiao-Lei Yu, Yi-Cun Hu, Rui-Hao Zhang, Xiao-Bo Zhang, Kun Zhang, Jiang-Dong An
Sci Rep. 2021; 11: 11165. Published online 2021 May 27. doi: 10.1038/s41598-021-89628-z
PMCID:
PMC8160131
AbstractArticlePDF–7.0M
6.
Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR‐140‐3p/SKA2 axis
Dongwei Dou, Xiaoyang Ren, Mingli Han, Xiaodong Xu, Xin Ge, Yuanting Gu, Xinxing Wang, Song Zhao
Mol Oncol. 2021 Feb; 15(2): 697–709. Published online 2020 Dec 7. doi: 10.1002/1878-0261.12862
PMCID:
PMC7858101
AbstractArticlePDF–2.2M
7.
HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Yiyun Sun, Dandan Xu, Chundong Zhang, Yitao Wang, Lian Zhang, Deqian Qiao, Youquan Bu, Ying Zhang
Genes (Basel) 2021 Jan; 12(1): 120. Published online 2021 Jan 19. doi: 10.3390/genes12010120
PMCID:
PMC7833434
AbstractArticlePDF–3.5M
8.
Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis
Wei Gao, Yuliang Zhang, Hongjie Luo, Min Niu, Xiwang Zheng, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Teng Ma, Lei Jin, Wei Xu, Yongyan Wu
Cell Death Dis. 2020 Oct; 11(10): 919. Published online 2020 Oct 26. doi: 10.1038/s41419-020-03104-6
PMCID:
PMC7589524
AbstractArticlePDF–5.2M
9.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors
Jerry Guintivano, Tori Brown, Alison Newcomer, Marcus Jones, Olivia Cox, Brion S. Maher, William W. Eaton, Jennifer L. Payne, Holly C. Wilcox, Zachary A. Kaminsky
Am J Psychiatry. Author manuscript; available in PMC 2020 Mar 19.
Published in final edited form as: Am J Psychiatry. 2014 Dec 1; 171(12): 1287–1296. Published online 2014 Oct 31. doi: 10.1176/appi.ajp.2014.14010008
PMCID:
PMC7081376
AbstractArticlePDF–560K
12.
Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling
Pim J Huis in 't Veld, Vladimir A Volkov, Isabelle D Stender, Andrea Musacchio, Marileen Dogterom
eLife. 2019; 8: e49539. Published online 2019 Dec 5. doi: 10.7554/eLife.49539
PMCID:
PMC6927755
AbstractArticlePDF–3.5M
13.
PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer
Yitao Wang, Chunxue Zhang, Li Mai, Yulong Niu, Yingxiong Wang, Youquan Bu
BMB Rep. 2019 Feb; 52(2): 157–162. Published online 2019 Feb 28. doi: 10.5483/BMBRep.2019.52.2.207
PMCID:
PMC6443325
AbstractArticlePDF–25M
14.
The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1
Haihua Wu, Yueyue Wang, Tiantian Chen, Yu Li, Haifeng Wang, Lingyu Zhang, Sulian Chen, Wenrui Wang, Qingling Yang, Changjie Chen
Biosci Rep. 2018 Oct 31; 38(5): BSR20180411. Prepublished online 2018 Aug 13. Published online 2018 Oct 17. doi: 10.1042/BSR20180411
PMCID:
PMC6200706
AbstractArticlePDF–3.3M
15.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations
Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo
Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2
PMCID:
PMC5864832
AbstractArticlePDF–4.5M
16.
Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore–microtubule attachments
Luke A. Helgeson, Alex Zelter, Michael Riffle, Michael J. MacCoss, Charles L. Asbury, Trisha N. Davis
Proc Natl Acad Sci U S A. 2018 Mar 13; 115(11): 2740–2745. Published online 2018 Feb 27. doi: 10.1073/pnas.1718553115
PMCID:
PMC5856539
AbstractArticlePDF–1.4M
17.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
18.
Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment
Philip Auckland, Nicholas I. Clarke, Stephen J. Royle, Andrew D. McAinsh
J Cell Biol. 2017 Jun 5; 216(6): 1623–1639. doi: 10.1083/jcb.201607096
PMCID:
PMC5461014
AbstractArticlePDF–3.8M
19.
The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells
Yitao Wang, Huali Weng, Ying Zhang, Yinjiang Long, Yi Li, Yulong Niu, Fangzhou Song, Youquan Bu
Int J Mol Sci. 2017 Mar; 18(3): 534. Published online 2017 Mar 1. doi: 10.3390/ijms18030534
PMCID:
PMC5372550
AbstractArticlePDF–2.8M
20.
A dynamic protein interaction landscape of the human centrosome-cilium interface
Gagan D. Gupta, Étienne Coyaud, João Gonçalves, Bahareh A. Mojarad, Yi Liu, Qianzhu Wu, Ladan Gheiratmand, David Comartin, Johnny M. Tkach, Sally W.T. Cheung, Mikhail Bashkurov, Monica Hasegan, James D. Knight, Zhen-Yuan Lin, Markus Schueler, Friedhelm Hildebrandt, Jason Moffat, Anne-Claude Gingras, Brian Raught, Laurence Pelletier
Cell. Author manuscript; available in PMC 2016 Dec 3.
Published in final edited form as: Cell. 2015 Dec 3; 163(6): 1484–1499. doi: 10.1016/j.cell.2015.10.065
PMCID:
PMC5089374
AbstractArticlePDF–1.5M

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