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Select item 96327591.

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda

Blood. 2022 Feb 3; 139(5): 748–760. doi: 10.1182/blood.2021012976

PMCID:: PMC9632759

Abstract Article

Select item 91332282.

CRLF2 overexpression results in reduced B cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome

Jacob J. Junco, Barry Zorman, Vincent U. Gant, Jr., Jaime Muñoz, H. Daniel Lacorazza, Pavel Sumazin, Karen R. Rabin

Exp Hematol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Hematol. 2022 Jun; 110: 34–38. Published online 2022 Mar 17. doi: 10.1016/j.exphem.2022.03.005

PMCID:: PMC9133228

Abstract Article PDF–481K

Select item 84696133.

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression

Abdelhabib Semlali, Mikhlid H. Almutairi, Abdullah Alamri, Narasimha Reddy Parine, Maha Arafah, Majid A. Almadi, Abdulrahman M. Aljebreen, Othman Alharbi, Nahla Ali Azzam, Riyadh Almutairi, Mohammad Alanazi, Mahmoud Rouabhia

Genes (Basel) 2021 Sep; 12(9): 1386. Published online 2021 Sep 6. doi: 10.3390/genes12091386

PMCID:: PMC8469613

Abstract Article PDF–1.9M

Select item 82886564.

Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia

Steven D. Mittelman, Jiyoon Kim, Gordana Raca, Gang Li, Matthew J. Oberley, Etan Orgel

Blood. 2021 Jul 15; 138(2): 199–202. Prepublished online 2021 Apr 19. doi: 10.1182/blood.2021011106

PMCID:: PMC8288656

Article

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 69077666.

Clinical characterization and prognosis of T cell acute lymphoblastic leukemia with high CRLF2 gene expression in children

Mingmin Wang, Jinquan Wen, Yuxia Guo, Yali Shen, Xizhou An, Yanni Hu, Jianwen Xiao

PLoS One. 2019; 14(12): e0224652. Published online 2019 Dec 12. doi: 10.1371/journal.pone.0224652

PMCID:: PMC6907766

Abstract Article PDF–769K

Select item 66876457.

TSLP and TSLP receptors variants are associated with smoking

Abdelhabib Semlali, Mikhlid Almutairi, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Saleh Alsulami, Talal Meshal Alumri, Mohammad Saud Alanazi, Mahmoud Rouabhia

Mol Genet Genomic Med. 2019 Aug; 7(8): e842. Published online 2019 Jul 9. doi: 10.1002/mgg3.842

PMCID:: PMC6687645

Abstract Article PDF–890K

Select item 66389748.

CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition

Lauren K. Meyer, Cristina Delgado-Martin, Shannon L. Maude, Kevin M. Shannon, David T. Teachey, Michelle L. Hermiston

PLoS One. 2019; 14(7): e0220026. Published online 2019 Jul 18. doi: 10.1371/journal.pone.0220026

PMCID:: PMC6638974

Abstract Article PDF–923K

Select item 63985889.

Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia

N Potter, L Jones, H Blair, S Strehl, CJ Harrison, M Greaves, L Kearney, LJ Russell

Leukemia. Author manuscript; available in PMC 2019 May 28.

Published in final edited form as: Leukemia. 2019 Apr; 33(4): 893–904. Published online 2018 Nov 28. doi: 10.1038/s41375-018-0297-4

PMCID:: PMC6398588

Abstract Article PDF–1.1M

Select item 631295910.

Potential efficacy and prognosis of silencing the CRLF2-mediated AKT/mTOR pathway in pediatric acute B-cell lymphoblastic leukemia

Min Jiang, Xueqin Zou, Lingyun Lu

Oncol Rep. 2019 Feb; 41(2): 885–894. Published online 2018 Dec 7. doi: 10.3892/or.2018.6917

PMCID:: PMC6312959

Abstract Article PDF–806K

Select item 608543211.

Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and the TSLP/TSLPR Axis on Risk of Coronary Artery Disease

Shao-Fang Nie, Ling-Feng Zha, Qian Fan, Yu-Hua Liao, Hong-Song Zhang, Qian-Wen Chen, Fan Wang, Ting-Ting Tang, Ni Xia, Cheng-Qi Xu, Jiao-Yue Zhang, Yu-Zhi Lu, Zhi-Peng Zeng, Jiao Jiao, Yuan-Yuan Li, Tian Xie, Wen-Juan Zhang, Dan Wang, Chu-Chu Wang, Jing-Jing Fa, Hong-Bo Xiong, Jian Ye, Qing Yang, Peng-Yun Wang, Sheng-Hua Tian, Qiu-Lun Lv, Qing-Xian Li, Jin Qian, Bin Li, Gang Wu, Yan-Xia Wu, Yan Yang, Xiang-Ping Yang, Yu Hu, Qing K. Wang, Xiang Cheng, Xin Tu

Front Immunol. 2018; 9: 1775. Published online 2018 Aug 3. doi: 10.3389/fimmu.2018.01775

PMCID:: PMC6085432

Abstract Article PDF–1.0M

Select item 577327812.

t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not

Albert G. Tsai, Akinori Yoda, David M. Weinstock, Michael R. Lieber

Blood. 2010 Sep 16; 116(11): 1993–1994. doi: 10.1182/blood-2010-05-286492

PMCID:: PMC5773278

Article

Select item 539631913.

Characterisation of the genomic landscape of CRLF2‐rearranged acute lymphoblastic leukemia

Lisa J. Russell, Lisa Jones, Amir Enshaei, Stefano Tonin, Sarra L. Ryan, Jeyanthy Eswaran, Sirintra Nakjang, Elli Papaemmanuil, Jose M. C. Tubio, Adele K. Fielding, Ajay Vora, Peter J. Campbell, Anthony V. Moorman, Christine J. Harrison

Genes Chromosomes Cancer. 2017 May; 56(5): 363–372. Published online 2017 Jan 18. doi: 10.1002/gcc.22439

PMCID:: PMC5396319

Abstract Article PDF–559K

Select item 532406414.

Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption

Chih-Yung Chiu, Shih-Chi Su, Wen-Lang Fan, Shen-Hao Lai, Ming-Han Tsai, Shih-Hsiang Chen, Kin-Sun Wong, Wen-Hung Chung

Sci Rep. 2017; 7: 43469. Published online 2017 Feb 24. doi: 10.1038/srep43469

PMCID:: PMC5324064

Abstract Article PDF–1.0M

Select item 531231015.

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia

Chiara Palmi, Angela M. Savino, Daniela Silvestri, Ilaria Bronzini, Gunnar Cario, Maddalena Paganin, Barbara Buldini, Marta Galbiati, Martina U. Muckenthaler, Cristina Bugarin, Pamela Della Mina, Stefan Nagel, Elena Barisone, Fiorina Casale, Franco Locatelli, Luca Lo Nigro, Concetta Micalizzi, Rosanna Parasole, Andrea Pession, Maria C. Putti, Nicola Santoro, Anna M. Testi, Ottavio Ziino, Andreas E. Kulozik, Martin Zimmermann, Martin Schrappe, Antonello Villa, Giuseppe Gaipa, Giuseppe Basso, Andrea Biondi, Maria G. Valsecchi, Martin Stanulla, Valentino Conter, Geertruy te Kronnie, Giovanni Cazzaniga

Oncotarget. 2016 Sep 13; 7(37): 59260–59272. Published online 2016 Jul 15. doi: 10.18632/oncotarget.10610

PMCID:: PMC5312310

Abstract Article PDF–2.7M

Select item 522654216.

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement

Zheng Ge, Yan Gu, Gang Zhao, Jianyong Li, Baoan Chen, Qi Han, Xing Guo, Juan Liu, Hui Li, Michael D. Yu, Justin Olson, Sadie Steffens, Kimberly J. Payne, Chunhua Song, Sinisa Dovat

Oncotarget. 2016 Aug 2; 7(31): 49722–49732. Published online 2016 Jul 6. doi: 10.18632/oncotarget.10437

PMCID:: PMC5226542

Abstract Article PDF–5.5M

Select item 440431017.

Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia

Sarah K. Tasian, Mignon L. Loh

Crit Rev Oncog. Author manuscript; available in PMC 2015 Apr 20.

Published in final edited form as: Crit Rev Oncog. 2011; 16(0): 13–24. doi: 10.1615/critrevoncog.v16.i1-2.30

PMCID:: PMC4404310

Abstract Article PDF–483K

Select item 419431418.

Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2–harboring clones as main relapse-driving force in childhood ALL

Maria Morak, Andishe Attarbaschi, Susanna Fischer, Christine Nassimbeni, Reinhard Grausenburger, Stephan Bastelberger, Stefanie Krentz, Gunnar Cario, David Kasper, Klaus Schmitt, Lisa J. Russell, Ulrike Pötschger, Martin Stanulla, Conny Eckert, Georg Mann, Oskar A. Haas, Renate Panzer-Grümayer

Blood. Author manuscript; available in PMC 2014 Oct 13.

Published in final edited form as: Blood. 2012 Dec 20; 120(26): 5134–5142. Published online 2012 Oct 22. doi: 10.1182/blood-2012-07-443218

Correction in:: Blood, volume 122 on page 1328

PMCID:: PMC4194314

Abstract Article PDF–1012K

Select item 405025019.

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood–brain barrier dysfunction

Shawna M Woollard, Biju Bhargavan, Fang Yu, Georgette D Kanmogne

J Cereb Blood Flow Metab. 2014 Jun; 34(6): 1047–1059. Published online 2014 Mar 26. doi: 10.1038/jcbfm.2014.54

PMCID:: PMC4050250

Abstract Article PDF–932K

Select item 379546120.

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL

Arian van der Veer, Esmé Waanders, Rob Pieters, Marieke E. Willemse, Simon V. Van Reijmersdal, Lisa J. Russell, Christine J. Harrison, William E. Evans, Vincent H. J. van der Velden, Peter M. Hoogerbrugge, Frank Van Leeuwen, Gabriele Escherich, Martin A. Horstmann, Leila Mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. De Groot-Kruseman, Edwin Sonneveld, Roland P. Kuiper, Monique L. Den Boer

Blood. 2013 Oct 10; 122(15): 2622–2629. Prepublished online 2013 Aug 23. doi: 10.1182/blood-2012-10-462358

PMCID:: PMC3795461

Abstract Article

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