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Items: 1 to 20 of 200

1.
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway
Ting Zheng, Ding Zhang, Qingzhen Fu, Mingxue Wang, Zesong Cheng, Yukun Cao, Liwan Wang, Jinyin Liu, Yashuang Zhao
Aging (Albany NY) 2024 Oct 15; 16(19): 12866–12892. Published online 2024 Oct 10. doi: 10.18632/aging.206115
PMCID:
PMC11501385
AbstractArticlePDF–4.4M
2.
Hyperactivation of ATF4/TGF-β1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant
Baowei Zhang, Yizhang Wu, Chunjiang Zhou, Jiaxi Xie, Youming Zhang, Xingbo Yang, Jing Xiao, Dao Wu Wang, Congjia Shan, Xiujuan Zhou, Yaozu Xiang, Bing Yang
BMC Med. 2024; 22: 361. Published online 2024 Sep 4. doi: 10.1186/s12916-024-03593-8
PMCID:
PMC11373413
AbstractArticlePDF–18M
3.
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
Feng He, Peng Zhang, Junlai Liu, Ruolei Wang, Randal J. Kaufman, Benjamin C. Yaden, Michael Karin
J Hepatol. Author manuscript; available in PMC 2024 Aug 19.
Published in final edited form as: J Hepatol. 2023 Aug; 79(2): 362–377. Published online 2023 Mar 28. doi: 10.1016/j.jhep.2023.03.016
PMCID:
PMC11332364
AbstractArticlePDF–2.6M
4.
ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer
Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zhu
Sci Rep. 2024; 14: 13042. Published online 2024 Jun 6. doi: 10.1038/s41598-024-63895-y
PMCID:
PMC11156644
AbstractArticlePDF–3.9M
5.
Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control
Anna M. Smirnova, Vladislava Hronová, Mahabub Pasha Mohammad, Anna Herrmannová, Stanislava Gunišová, Denisa Petráčková, Petr Halada, Štěpán Coufal, Michał Świrski, Justin Rendleman, Kristína Jendruchová, Maria Hatzoglou, Petra Beznosková, Christine Vogel, Leoš Shivaya Valášek
Cell Rep. Author manuscript; available in PMC 2024 Apr 30.
Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 113976. Published online 2024 Mar 19. doi: 10.1016/j.celrep.2024.113976
PMCID:
PMC11058473
AbstractArticlePDF–2.1M
6.
miR-214 aggravates oxidative stress in thalassemic erythroid cells by targeting ATF4
Tipparat Penglong, Apisara Saensuwanna, Husanai Jantapaso, Pongpon Phuwakanjana, Natee Jearawiriyapaisarn, Kittiphong Paiboonsukwong, Worrawit Wanichsuwan, Kanitta Srinoun
PLoS One. 2024; 19(4): e0300958. Published online 2024 Apr 16. doi: 10.1371/journal.pone.0300958
PMCID:
PMC11020981
AbstractArticlePDF–2.1M
7.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
Sheng Yang, JiaJun Xie, ZhiJie Pan, HongMei Guan, YueSheng Tu, YuanJian Ye, ShouBin Huang, ShiQiang Fu, KangXian Li, ZhiWei Huang, XiaoQi Li, ZhanJun Shi, Le Li, Yang Zhang
Exp Mol Med. 2024 Mar; 56(3): 630–645. Published online 2024 Mar 1. doi: 10.1038/s12276-024-01190-6
PMCID:
PMC10985079
AbstractArticlePDF–8.4M
8.
Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs
Tiit Örd, Daima Örd, Priit Adler, Tõnis Örd
PLoS Genet. 2023 Oct; 19(10): e1011014. Published online 2023 Oct 31. doi: 10.1371/journal.pgen.1011014
PMCID:
PMC10637723
AbstractArticlePDF–3.2M
9.
Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival
Meng Li, Matthew R. Teater, Jun Young Hong, Noel R. Park, Cihangir Duy, Hao Shen, Ling Wang, Zhengming Chen, Leandro Cerchietti, Shawn M. Davidson, Hening Lin, Ari M. Melnick
Blood Cancer Discov. 2022 Jan; 3(1): 50–65. Published online 2021 Nov 9. doi: 10.1158/2643-3230.BCD-20-0183
PMCID:
PMC9789686
AbstractArticlePDF–7.6M
10.
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF
Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O. Rosas, Guoying Yu
Int J Mol Sci. 2022 Dec; 23(24): 15705. Published online 2022 Dec 11. doi: 10.3390/ijms232415705
PMCID:
PMC9778945
AbstractArticlePDF–4.1M
11.
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus
Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li, Ersheng Kuang
J Virol. 2022 Dec; 96(23): e01456-22. Published online 2022 Nov 15. doi: 10.1128/jvi.01456-22
PMCID:
PMC9749464
AbstractArticlePDF–3.8M
12.
Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells
Nancy T. Chee, Candace H. Carriere, Zachary Miller, Scott Welford, Shaun P. Brothers
Oncol Rep. 2023 Jan; 49(1): 14. Published online 2022 Nov 23. doi: 10.3892/or.2022.8451
PMCID:
PMC9713860
AbstractArticlePDF–1.8M
13.
ATF4-dependent fructolysis fuels growth of glioblastoma multiforme
Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You, Xinjian Li
Nat Commun. 2022; 13: 6108. Published online 2022 Oct 16. doi: 10.1038/s41467-022-33859-9
PMCID:
PMC9573865
AbstractArticlePDF–3.1M
14.
ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis
Yixing Gao, Lan Feng, Luping Zhang, Jianhui Geng, Erlong Zhang
Dis Markers. 2022; 2022: 7527996. Published online 2022 Aug 22. doi: 10.1155/2022/7527996
PMCID:
PMC9425107
AbstractArticlePDF–2.2M
15.
uORF-Mediated Translational Regulation of ATF4 Serves as an Evolutionarily Conserved Mechanism Contributing to Non-Small-Cell Lung Cancer (NSCLC) and Stress Response
Wenjing Xiao, Yang Sun, Jinpeng Xu, Na Zhang, Lina Dong
J Mol Evol. 2022; 90(5): 375–388. Published online 2022 Aug 13. doi: 10.1007/s00239-022-10068-y
PMCID:
PMC9375200
AbstractArticlePDF–2.0M
16.
Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways
Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li
Cells. 2022 Jul; 11(14): 2136. Published online 2022 Jul 7. doi: 10.3390/cells11142136
PMCID:
PMC9324664
AbstractArticlePDF–14M
17.
ATF4 promotes brain vascular smooth muscle cells proliferation, invasion and migration by targeting miR-552-SKI axis
Meina Feng, Qin Zhou, Wenxian Tu, Yunfeng Wang, Yuanmin Du, Kang Xu
PLoS One. 2022; 17(7): e0270880. Published online 2022 Jul 20. doi: 10.1371/journal.pone.0270880
PMCID:
PMC9299314
AbstractArticlePDF–3.6M
18.
Induction of DR5-Dependent Apoptosis by PGA2 through ATF4-CHOP Pathway
Kyeong-Min Park, Ji-Young Park, Jaehyuk Pyo, Sun-Young Lee, Ho-Shik Kim
Molecules. 2022 Jun; 27(12): 3804. Published online 2022 Jun 13. doi: 10.3390/molecules27123804
PMCID:
PMC9230093
AbstractArticlePDF–1.4M
19.
Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis
Lulu Guan, Feifei Wang, Mengjiao Wang, Songfeng Han, Zhaohai Cui, Shoumin Xi, Haixu Xu, Shipeng Li
Oxid Med Cell Longev. 2022; 2022: 9613095. Published online 2022 May 16. doi: 10.1155/2022/9613095
PMCID:
PMC9126659
AbstractArticlePDF–2.9M
20.
PRMT5 regulates ATF4 transcript splicing and oxidative stress response
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Redox Biol. 2022 May; 51: 102282. Published online 2022 Mar 11. doi: 10.1016/j.redox.2022.102282
PMCID:
PMC8933703
AbstractArticlePDF–8.9M

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