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Select item 112379431.

A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

Chuling Zhuang, Shen Yang, Carlos G. Gonzalez, Richard I. Ainsworth, Sheng Li, Masumi Takayama Kobayashi, Igor Wierzbicki, Leigh-Ana M. Rossitto, Yutao Wen, Wolfgang Peti, Stephanie M. Stanford, David J. Gonzalez, Ramachandran Murali, Eugenio Santelli, Nunzio Bottini

J Biol Chem. 2024 Jun; 300(6): 107393. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107393

PMCID:: PMC11237943

Abstract Article PDF–2.9M

Select item 106079902.

Association between PYTPN22 rs2476601, VEGF rs833070, TNFAIP3 rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study

Regina Sakalyte, Sigita Stropuviene, Gabija Jasionyte, Loreta Bagdonaite, Algirdas Venalis

Medicina (Kaunas) 2023 Oct; 59(10): 1824. Published online 2023 Oct 13. doi: 10.3390/medicina59101824

PMCID:: PMC10607990

Abstract Article PDF–323K

Select item 105858213.

CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus

Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao, Jun Tang

Arthritis Res Ther. 2023; 25: 206. Published online 2023 Oct 19. doi: 10.1186/s13075-023-03150-3

Correction in:: Arthritis Res Ther. 2024; 26: 39.

PMCID:: PMC10585821

Abstract Article PDF–2.6M

Select item 103477384.

Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng

BMC Med. 2023; 21: 252. Published online 2023 Jul 13. doi: 10.1186/s12916-023-02888-6

PMCID:: PMC10347738

Abstract Article PDF–14M

Select item 102666375.

PTPN22 intron polymorphism rs1310182 (c.2054-852T>C) is associated with type 1 diabetes mellitus in patients of Armenian descent

Robert Žak, Lusine Navasardyan, Ján Hunák, Jiřina Martinů, Petr Heneberg

PLoS One. 2023; 18(6): e0286743. Published online 2023 Jun 14. doi: 10.1371/journal.pone.0286743

PMCID:: PMC10266637

Abstract Article PDF–532K

Select item 100441516.

The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study

Nur Rochmah, Fatimah Arief, Muhammad Faizi, Sukmawati Basuki

Ann Med. 2023; 55(1): 1211–1215. Published online 2023 Mar 24. doi: 10.1080/07853890.2023.2190162

PMCID:: PMC10044151

Abstract Article PDF–504K

Select item 99224687.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 98913078.

HLA and Non-HLA gene polymorphisms in autoimmune hepatitis patients of North Indian adults

Nishtha Ahuja, Jagdeep Singh, Ranjana Walker Minz, Shashi Anand, Ashim Das, Sunil Taneja

Front Immunol. 2022; 13: 984083. Published online 2023 Jan 18. doi: 10.3389/fimmu.2022.984083

PMCID:: PMC9891307

Abstract Article PDF–1.2M

Select item 94154759.

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review

Kalthoum Tizaoui, Jae Il Shin, Gwang Hun Jeong, Jae Won Yang, Seoyeon Park, Ji Hong Kim, Soo Young Hwang, Se Jin Park, Ai Koyanagi, Lee Smith

Medicina (Kaunas) 2022 Aug; 58(8): 1034. Published online 2022 Aug 2. doi: 10.3390/medicina58081034

PMCID:: PMC9415475

Abstract Article PDF–390K

Select item 898991810.

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

Ben F. Brian, IV, Frances V. Sjaastad, Tanya S. Freedman

Sci Rep. 2022; 12: 5875. Published online 2022 Apr 7. doi: 10.1038/s41598-022-09589-9

PMCID:: PMC8989918

Abstract Article PDF–2.5M

Select item 876907211.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 865069912.

Recurrence of Graves’ Disease: What Genetics of HLA and PTPN22 Can Tell Us

Daniela Vejrazkova, Josef Vcelak, Eliska Vaclavikova, Marketa Vankova, Katerina Zajickova, Jana Vrbikova, Michaela Duskova, Petra Pacesova, Zdenek Novak, Bela Bendlova

Front Endocrinol (Lausanne) 2021; 12: 761077. Published online 2021 Nov 23. doi: 10.3389/fendo.2021.761077

PMCID:: PMC8650699

Abstract Article PDF–324K

Select item 856815713.

Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis

S. R. Gil-Quiñones, I. T. Sepúlveda-Pachón, G. Sánchez Vanegas, L. D. Gutierrez-Castañeda

PLoS One. 2021; 16(11): e0258499. Published online 2021 Nov 4. doi: 10.1371/journal.pone.0258499

PMCID:: PMC8568157

Abstract Article PDF–1.2M

Select item 832397014.

Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4⁺ T Cell Activation

Daniel J. Perry, Leeana D. Peters, Priya Saikumar Lakshmi, Lin Zhang, Zhao Han, Clive H. Wasserfall, Clayton E. Mathews, Mark A. Atkinson, Todd M. Brusko

J Immunol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: J Immunol. 2021 Aug 1; 207(3): 849–859. Published online 2021 Jul 23. doi: 10.4049/jimmunol.2000708

PMCID:: PMC8323970

Abstract Article PDF–1.5M

Select item 822039115.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795054417.

Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis

Shuping Li, Xiaohua Wang, Yuming Zhao, Juan Yang, Tianjiao Cui, Zhizhuang Joe Zhao, Yun Chen, Zhihua Zheng

Front Immunol. 2021; 12: 592841. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.592841

PMCID:: PMC7950544

Abstract Article PDF–1.2M

Select item 760486918.

Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy

Rafael Cubas, Zia Khan, Qian Gong, Marina Moskalenko, Huizhong Xiong, Qinglin Ou, Christine Pai, Ryan Rodriguez, Jeanne Cheung, Andrew C Chan

J Immunother Cancer. 2020; 8(2): e001439. Published online 2020 Oct 30. doi: 10.1136/jitc-2020-001439

PMCID:: PMC7604869

Abstract Article PDF–3.0M

Select item 755981719.

rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?

Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller, Stefan Reichert

J Transl Med. 2020; 18: 389. Published online 2020 Oct 15. doi: 10.1186/s12967-020-02548-w

PMCID:: PMC7559817

Abstract Article PDF–1.0M

Select item 753664320.

Genome-wide Study Identifies Association between HLA-B^∗55:01 and Self-Reported Penicillin Allergy

Kristi Krebs, Jonas Bovijn, Neil Zheng, Maarja Lepamets, Jenny C. Censin, Tuuli Jürgenson, Dage Särg, Erik Abner, Triin Laisk, Yang Luo, Line Skotte, Frank Geller, Bjarke Feenstra, Wei Wang, Adam Auton, 23andMe Research Team, Soumya Raychaudhuri, Tõnu Esko, Andres Metspalu, Sven Laur, Dan M. Roden, Wei-Qi Wei, Michael V. Holmes, Cecilia M. Lindgren, Elizabeth J. Phillips, Reedik Mägi, Lili Milani, João Fadista

Am J Hum Genet. 2020 Oct 1; 107(4): 612–621. Published online 2020 Sep 3. doi: 10.1016/j.ajhg.2020.08.008

PMCID:: PMC7536643

Abstract Article PDF–917K

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