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Select item 112369111.

MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis

Lixian Ding, Mingjun Sun, Yanyan Sun, Jinxing Li, Zhicheng Zhang, Shuwei Dang, Jinning Zhang, Bang Yang, Youlin Dai, Qinghao Zhou, Dazhi Zhou, Encheng Li, Shuqi Peng, Guodong Li

Cancer Med. 2024 Jul; 13(13): e7424. Published online 2024 Jul 10. doi: 10.1002/cam4.7424

PMCID:: PMC11236911

Abstract Article PDF–56M

Select item 110558652.

Mechanism of DNA unwinding by MCM8-9 in complex with HROB

Ananya Acharya, Hélène Bret, Jen-Wei Huang, Martin Mütze, Martin Göse, Vera Maria Kissling, Ralf Seidel, Alberto Ciccia, Raphaël Guérois, Petr Cejka

Nat Commun. 2024; 15: 3584. Published online 2024 Apr 27. doi: 10.1038/s41467-024-47936-8

PMCID:: PMC11055865

Abstract Article PDF–4.9M

Select item 104151413.

Activity, substrate preference and structure of the HsMCM8/9 helicase

David R McKinzey, Chuxuan Li, Yang Gao, Michael A Trakselis

Nucleic Acids Res. 2023 Aug 11; 51(14): 7330–7341. Published online 2023 Jun 13. doi: 10.1093/nar/gkad508

PMCID:: PMC10415141

Abstract Article PDF–1.8M

Select item 102864464.

Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics

Yu-meng Sun, Yi-meng Zhang, Hai-liang Shi, Song Yang, Yin-long Zhao, Hong-jiang Liu, Chen Li, Hong-lei Liu, Ji-peng Yang, Jian Song, Guo-zhu Sun, Jian-kai Yang

Hereditas. 2023; 160: 29. Published online 2023 Jun 22. doi: 10.1186/s41065-023-00292-x

PMCID:: PMC10286446

Abstract Article PDF–5.3M

Select item 101516155.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 91197366.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80273808.

Knockdown of MCM8 functions as a strategy to inhibit the development and progression of osteosarcoma through regulating CTGF

Zhinan Ren, Jun Li, Shanwen Zhao, Qi Qiao, Runguang Li

Cell Death Dis. 2021 Apr; 12(4): 376. Published online 2021 Apr 7. doi: 10.1038/s41419-021-03621-y

PMCID:: PMC8027380

Abstract Article PDF–3.4M

Select item 77538729.

Identification of mini‐chromosome maintenance 8 as a potential prognostic marker and its effects on proliferation and apoptosis in gastric cancer

Bin Huang, Minghe Lin, Lisha Lu, Wujin Chen, Jingzhuang Tan, Jinyan Zhao, Zhiyun Cao, Xiaoqin Zhu, Jiumao Lin

J Cell Mol Med. 2020 Dec; 24(24): 14415–14425. Published online 2020 Nov 6. doi: 10.1111/jcmm.16062

PMCID:: PMC7753872

Abstract Article PDF–2.2M

Select item 756688110.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 752653811.

Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome

Mariano Golubicki, Laia Bonjoch, José G. Acuña-Ochoa, Marcos Díaz-Gay, Jenifer Muñoz, Miriam Cuatrecasas, Teresa Ocaña, Soledad Iseas, Guillermo Mendez, Daniel Cisterna, Stephanie A. Schubert, Maartje Nielsen, Tom van Wezel, Yael Goldberg, Eli Pikarsky, Juan Robbio, Enrique Roca, Antoni Castells, Francesc Balaguer, Marina Antelo, Sergi Castellví-Bel

JCI Insight. 2020 Sep 17; 5(18): e140698. Published online 2020 Sep 17. doi: 10.1172/jci.insight.140698

PMCID:: PMC7526538

Abstract Article PDF–20M

Select item 750756612.

Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature

Fei Wang, Sheng Guo, Pin Li

Mol Genet Genomic Med. 2020 Sep; 8(9): e1396. Published online 2020 Jul 11. doi: 10.1002/mgg3.1396

PMCID:: PMC7507566

Abstract Article PDF–1.2M

Select item 729003213.

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia

Nat Commun. 2020; 11: 2948. Published online 2020 Jun 11. doi: 10.1038/s41467-020-16718-3

PMCID:: PMC7290032

Abstract Article PDF–3.0M

Select item 719645814.

Novel loss‐of‐function mutation in MCM8 causes premature ovarian insufficiency

Ya‐Xin Zhang, Wen‐Bin He, Wen‐Juan Xiao, Lan‐Lan Meng, Chen Tan, Juan Du, Guang‐Xiu Lu, Ge Lin, Yue‐Qiu Tan

Mol Genet Genomic Med. 2020 Apr; 8(4): e1165. Published online 2020 Feb 11. doi: 10.1002/mgg3.1165

PMCID:: PMC7196458

Abstract Article PDF–838K

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 694204416.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 677139217.

Control of homologous recombination by the HROB–MCM8–MCM9 pathway

Nicole Hustedt, Yuichiro Saito, Michal Zimmermann, Alejandro Álvarez-Quilón, Dheva Setiaputra, Salomé Adam, Andrea McEwan, Jing Yi Yuan, Michele Olivieri, Yichao Zhao, Masato T. Kanemaki, Andrea Jurisicova, Daniel Durocher

Genes Dev. 2019 Oct 1; 33(19-20): 1397–1415. doi: 10.1101/gad.329508.119

PMCID:: PMC6771392

Abstract Article PDF–6.3M

Select item 664111418.

Genome-wide investigation of the clinical significance and prospective molecular mechanism of minichromosome maintenance protein family genes in patients with Lung Adenocarcinoma

Kang Liu, Min Kang, Xiwen Liao, Rensheng Wang

PLoS One. 2019; 14(7): e0219467. Published online 2019 Jul 19. doi: 10.1371/journal.pone.0219467

PMCID:: PMC6641114

Abstract Article PDF–9.2M

Select item 639888319.

Inhibiting the MCM8‐9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Issay Morii, Yukiko Iwabuchi, Sumiko Mori, Masaki Suekuni, Toyoaki Natsume, Kazumasa Yoshida, Nozomi Sugimoto, Masato T. Kanemaki, Masatoshi Fujita

Cancer Sci. 2019 Mar; 110(3): 1044–1053. Published online 2019 Feb 14. doi: 10.1111/cas.13941

PMCID:: PMC6398883

Abstract Article PDF–883K

Select item 616668220.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

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