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Select item 110313601.

Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity

Beatriz Fernández-Varas, Cristina Manguan-García, Javier Rodriguez-Centeno, Lucía Mendoza-Lupiáñez, Joaquin Calatayud, Rosario Perona, Mercedes Martín-Martínez, Marta Gutierrez-Rodriguez, Carlos Benítez-Buelga, Leandro Sastre

Hum Mol Genet. 2024 May 1; 33(9): 818–834. Published online 2024 Feb 3. doi: 10.1093/hmg/ddae015

PMCID:: PMC11031360

Abstract Article PDF–2.5M

Select item 103320962.

TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia

Xinyu Tang, Ruirong Xu, Yan Wang, Kaiqing Chen, Siyuan Cui

Mol Med. 2023; 29: 94. Published online 2023 Jul 9. doi: 10.1186/s10020-023-00691-w

PMCID:: PMC10332096

Abstract Article PDF–1.0M

Select item 94095043.

Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors

Radwa Sharaf, Garrett M. Frampton, Lee A. Albacker

PLoS One. 2022; 17(8): e0272707. Published online 2022 Aug 25. doi: 10.1371/journal.pone.0272707

PMCID:: PMC9409504

Abstract Article PDF–1.6M

Select item 90232804.

Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity

Shu Wu, Yuanlong Ge, Kaixuan Lin, Qianqian Liu, Haoxian Zhou, Qian Hu, Yong Zhao, Weifeng He, Zhenyu Ju

Nucleic Acids Res. 2022 Apr 22; 50(7): 3764–3776. Published online 2022 Mar 22. doi: 10.1093/nar/gkac179

PMCID:: PMC9023280

Abstract Article PDF–3.8M

Select item 86748235.

Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension

Hui-Ting Lee, Samantha Sanford, Tapas Paul, Joshua Choe, Arindam Bose, Patricia L. Opresko, Sua Myong

Biochemistry. Author manuscript; available in PMC 2021 Dec 16.

Published in final edited form as: Biochemistry. 2020 Jul 21; 59(28): 2627–2639. Published online 2020 Jun 29. doi: 10.1021/acs.biochem.0c00434

PMCID:: PMC8674823

Abstract Article PDF–2.3M

Select item 84928056.

Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence

Tove Lekva, Marie Cecilie Paasche Roland, Mette E. Estensen, Errol R. Norwitz, Tamara Tilburgs, Tore Henriksen, Jens Bollerslev, Kjersti R. Normann, Per Magnus, Ole Kristoffer Olstad, Pål Aukrust, Thor Ueland

Sci Rep. 2021; 11: 19735. Published online 2021 Oct 5. doi: 10.1038/s41598-021-99140-z

Correction in:: Sci Rep. 2021; 11: 22572.

PMCID:: PMC8492805

Abstract Article PDF–1.7M

Select item 83641777.

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis

Jesús García-Castillo, Francisca Alcaraz-Pérez, Elena Martínez-Balsalobre, Diana García-Moreno, Marlies P. Rossmann, Miriam Fernández-Lajarín, Manuel Bernabé-García, Ana B. Pérez-Oliva, Virginia C. Rodríguez-Cortez, Clara Bueno, Isaac Adatto, Suneet Agarwal, Pablo Menéndez, Leonard I. Zon, Victoriano Mulero, María L. Cayuela

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2015528118. Published online 2021 Aug 5. doi: 10.1073/pnas.2015528118

PMCID:: PMC8364177

Abstract Article PDF–1.8M

Select item 79827218.

Prognostic Association of TERC, TERT Gene Polymorphism, and Leukocyte Telomere Length in Acute Heart Failure: A Prospective Study

Yanxiu Li, Iokfai Cheang, Zhongwen Zhang, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yun Liu, Xiangrong Zuo, Xinli Li, Quan Cao

Front Endocrinol (Lausanne) 2021; 12: 650922. Published online 2021 Mar 8. doi: 10.3389/fendo.2021.650922

PMCID:: PMC7982721

Abstract Article PDF–1001K

Select item 77893279.

TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda

Allan Kalungi, Eugene Kinyanda, Jacqueline S. Womersley, Moses L. Joloba, Wilber Ssembajjwe, Rebecca N. Nsubuga, Pontiano Kaleebu, Jonathan Levin, Martin Kidd, Soraya Seedat, Sian M. J. Hemmings

BMC Med Genomics. 2021; 14: 15. Published online 2021 Jan 6. doi: 10.1186/s12920-020-00857-z

PMCID:: PMC7789327

Abstract Article PDF–1.1M

Select item 758403910.

Comparable Effects of the Androgen Derivatives Danazol, Oxymetholone and Nandrolone on Telomerase Activity in Human Primary Hematopoietic Cells from Patients with Dyskeratosis Congenita

Margherita Vieri, Martin Kirschner, Mareike Tometten, Anne Abels, Benjamin Rolles, Susanne Isfort, Jens Panse, Tim H. Brümmendorf, Fabian Beier

Int J Mol Sci. 2020 Oct; 21(19): 7196. Published online 2020 Sep 29. doi: 10.3390/ijms21197196

PMCID:: PMC7584039

Abstract Article PDF–1.0M

Select item 748467111.

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Guanghui Cheng, Lina Wang, Mingkai Dai, Fengtao Wei, Dawei Xu

Int J Med Sci. 2020; 17(14): 2180–2186. Published online 2020 Aug 1. doi: 10.7150/ijms.48456

PMCID:: PMC7484671

Abstract Article PDF–533K

Select item 737074812.

Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer

Haizhen He, Qionghui Pan, Jiajia Pan, Yumei Chen, Liqin Cao

J Clin Lab Anal. 2020 Jul; 34(7): e23257. Published online 2020 Feb 26. doi: 10.1002/jcla.23257

PMCID:: PMC7370748

Abstract Article PDF–425K

Select item 734970513.

TERC Variants Associated with Short Leukocyte Telomeres: Implication of Higher Early Life Leukocyte Telomere Attrition as Assessed by the Blood-and-Muscle Model

Simon Toupance, Maria G. Stathopoulou, Alexandros M. Petrelis, Vesna Gorenjak, Carlos Labat, Tsung-Po Lai, Sophie Visvikis-Siest, Athanase Benetos

Cells. 2020 Jun; 9(6): 1360. Published online 2020 May 31. doi: 10.3390/cells9061360

PMCID:: PMC7349705

Abstract Article PDF–1.2M

Select item 732206714.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 724635015.

Relevance research between the expression of p16^INK4a, Notch1, and hTERC genes: The development of HPV16‐positive cervical cancer

Wenyan Huo, Shuaiyu Zhai, Yanbo Wang, Xin Qiang, Risu Na, Hua Gui, Ningjin Wu, Yaning Cao, Haihua Bai

J Clin Lab Anal. 2020 May; 34(5): e23207. Published online 2020 Jan 24. doi: 10.1002/jcla.23207

PMCID:: PMC7246350

Abstract Article PDF–917K

Select item 689120916.

Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

Mindy K. Graham, Jiyoung Kim, Joseph Da, Jacqueline A. Brosnan-Cashman, Anthony Rizzo, Javier A. Baena Del Valle, Lionel Chia, Michael Rubenstein, Christine Davis, Qizhi Zheng, Leslie Cope, Michael Considine, Michael C. Haffner, Angelo M. De Marzo, Alan K. Meeker, Christopher M. Heaphy

Mol Cancer Res. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Mol Cancer Res. 2019 Dec; 17(12): 2480–2491. Published online 2019 Oct 14. doi: 10.1158/1541-7786.MCR-19-0654

PMCID:: PMC6891209

Abstract Article PDF–1.5M

Select item 673576717.

TERC promotes cellular inflammatory response independent of telomerase

Haiying Liu, Yiding Yang, Yuanlong Ge, Juanhong Liu, Yong Zhao

Nucleic Acids Res. 2019 Sep 5; 47(15): 8084–8095. Published online 2019 Jul 11. doi: 10.1093/nar/gkz584

PMCID:: PMC6735767

Abstract Article PDF–1.8M

Select item 671188018.

Mitochondrion-processed TERC regulates senescence without affecting telomerase activities

Qian Zheng, Peipei Liu, Ge Gao, Jiapei Yuan, Pengfeng Wang, Jinliang Huang, Leiming Xie, Xinping Lu, Fan Di, Tanjun Tong, Jun Chen, Zhi Lu, Jisong Guan, Geng Wang

Protein Cell. 2019 Sep; 10(9): 631–648. Published online 2019 Feb 20. doi: 10.1007/s13238-019-0612-5

PMCID:: PMC6711880

Abstract Article PDF–3.3M

Select item 652502319.

Disruption of telomerase RNA maturation kinetics precipitates disease

Caitlin M. Roake, Lu Chen, Ananya Chakravarthy, Grazia D. Raffa, James E. Ferrell, Jr., Steven E. Artandi

Mol Cell. Author manuscript; available in PMC 2020 May 16.

Published in final edited form as: Mol Cell. 2019 May 16; 74(4): 688–700.e3. Published online 2019 Mar 28. doi: 10.1016/j.molcel.2019.02.033

PMCID:: PMC6525023

Abstract Article PDF–1.7M

Select item 636863720.

Integrator is a key component of human telomerase RNA biogenesis

M. P. Rubtsova, D. P. Vasilkova, M. A. Moshareva, A. N. Malyavko, M. B. Meerson, T. S. Zatsepin, Y. V. Naraykina, A. V. Beletsky, N. V. Ravin, O. A. Dontsova

Sci Rep. 2019; 9: 1701. Published online 2019 Feb 8. doi: 10.1038/s41598-018-38297-6

PMCID:: PMC6368637

Abstract Article PDF–1.9M

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