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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699832.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69812063.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 65296414.

SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response

Namit Sharma, Marta Ponce, Savar Kaul, Zhongda Pan, Donna M. Berry, Thomas Eiwegger, Catherine J. McGlade

Front Immunol. 2019; 10: 1020. Published online 2019 May 15. doi: 10.3389/fimmu.2019.01020

PMCID:: PMC6529641

Abstract Article PDF–3.3M

Select item 55316115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 45391696.

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

Nikolett Marton, Eszter Baricza, Barbara Érsek, Edit I. Buzás, György Nagy

Mediators Inflamm. 2015; 2015: 952536. Published online 2015 Aug 3. doi: 10.1155/2015/952536

PMCID:: PMC4539169

Abstract Article PDF–2.3M

Select item 40831107.

Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome

Kin K. Leung, Ronald J. Hause, Jr., John L. Barkinge, Mark F. Ciaccio, Chih-Pin Chuu, Richard B. Jones

Mol Cell Proteomics. 2014 Jul; 13(7): 1705–1723. Published online 2014 Apr 12. doi: 10.1074/mcp.M113.034876

PMCID:: PMC4083110

Abstract Article PDF–6.6M

Select item 40661558.

Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm

Chun-Xia Wang, Andreas Teufel, Uta Cheruti, Joachim Grötzinger, Peter R Galle, Ansgar W Lohse, Johannes Herkel

World J Gastroenterol. 2006 Feb 14; 12(6): 902–907. Published online 2006 Feb 14. doi: 10.3748/wjg.v12.i6.902

PMCID:: PMC4066155

Abstract Article PDF–747K

Select item 35340559.

Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling

Julhash U. Kazi, Lars Rönnstrand

PLoS One. 2012; 7(12): e53509. Published online 2012 Dec 31. doi: 10.1371/journal.pone.0053509

PMCID:: PMC3534055

Abstract Article PDF–1.0M

Select item 343342010.

Comprehensive Binary Interaction Mapping of SH2 Domains via Fluorescence Polarization Reveals Novel Functional Diversification of ErbB Receptors

Ronald J. Hause, Jr., Kin K. Leung, John L. Barkinge, Mark F. Ciaccio, Chih-pin Chuu, Richard B. Jones

PLoS One. 2012; 7(9): e44471. Published online 2012 Sep 4. doi: 10.1371/journal.pone.0044471

PMCID:: PMC3433420

Abstract Article PDF–1.1M

Select item 336604411.

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

Ying Jin, Stanca A Birlea, Pamela R Fain, Tracey M Ferrara, Songtao Ben, Sheri L Riccardi, Joanne B Cole, Katherine Gowan, Paulene J Holland, Dorothy C Bennett, Rosalie M Luiten, Albert Wolkerstorfer, JP Wietze van der Veen, Anke Hartmann, Saskia Eichner, Gerold Schuler, Nanja van Geel, Jo Lambert, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Margaret R Wallace, Wayne T McCormack, Mauro Picardo, Giovanni Leone, Andreas Overbeck, Nanette B Silverberg, Richard A Spritz

Nat Genet. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: Nat Genet. 2012 Jun; 44(6): 676–680. Published online 2012 May 6. doi: 10.1038/ng.2272

PMCID:: PMC3366044

Abstract Article PDF–320K

Select item 336525612.

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales

S K Service, K J H Verweij, J Lahti, E Congdon, J Ekelund, M Hintsanen, K Räikkönen, T Lehtimäki, M Kähönen, E Widen, A Taanila, J Veijola, A C Heath, P A F Madden, G W Montgomery, C Sabatti, M-R Järvelin, A Palotie, O Raitakari, J Viikari, N G Martin, J G Eriksson, L Keltikangas-Järvinen, N R Wray, N B Freimer

Transl Psychiatry. 2012 May; 2(5): e116. Published online 2012 May 15. doi: 10.1038/tp.2012.37

PMCID:: PMC3365256

Abstract Article PDF–409K

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 300858614.

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Eric J. Bennett, John Rush, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2011 Dec 10.

Published in final edited form as: Cell. 2010 Dec 10; 143(6): 951–965. doi: 10.1016/j.cell.2010.11.017

PMCID:: PMC3008586

Abstract Article PDF–3.0M

Select item 289646415.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 219597916.

Functional Cloning of Src-like Adapter Protein-2 (SLAP-2), a Novel Inhibitor of Antigen Receptor Signaling

Sacha J. Holland, X. Charlene Liao, Marcy K. Mendenhall, Xiulan Zhou, Jorge Pardo, Peter Chu, Collin Spencer, Alan Fu, Ning Sheng, Peiwen Yu, Erlina Pali, Anup Nagin, Mary Shen, Simon Yu, Eva Chan, Xian Wu, Connie Li, Max Woisetschlager, Gregorio Aversa, Frank Kolbinger, Mark K. Bennett, Susan Molineaux, Ying Luo, Donald G. Payan, Helena S.Y. Mancebo, Jun Wu

J Exp Med. 2001 Nov 5; 194(9): 1263–1276. doi: 10.1084/jem.194.9.1263

PMCID:: PMC2195979

Abstract Article PDF–395K

Select item 219582617.

Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling

Tomasz Sosinowski, Akhilesh Pandey, Vishva M. Dixit, Arthur Weiss

J Exp Med. 2000 Feb 7; 191(3): 463–474. doi: 10.1084/jem.191.3.463

PMCID:: PMC2195826

Abstract Article PDF–346K

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 13924120.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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