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Items: 1 to 20 of 85

1.
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development
Adina Sophie Graffunder, Audrey Amber Julie Bresser, Valeria Fernandez Vallone, Matthias Megges, Harald Stachelscheid, Peter Kühnen, Robert Opitz
Sci Rep. 2024; 14: 9355. Published online 2024 Apr 23. doi: 10.1038/s41598-024-59533-2
PMCID:
PMC11039642
AbstractArticlePDF–4.5M
2.
Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions
Maria Virginia Giolito, Théo La Rosa, Diana Farhat, Serguei Bodoirat, Gabriela D. A. Guardia, Claire Domon‐Dell, Pedro A. F. Galante, Jean‐Noel Freund, Michelina Plateroti
Mol Oncol. 2022 Dec; 16(22): 3975–3993. Published online 2022 Oct 10. doi: 10.1002/1878-0261.13298
PMCID:
PMC9718118
AbstractArticlePDF–2.2M
3.
ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold
Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134
PMCID:
PMC9475462
AbstractArticlePDF–4.6M
4.
Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality
Malte Sandsveden, Signe Borgquist, Ann H. Rosendahl, Jonas Manjer
Breast Cancer Res. 2021; 23: 117. Published online 2021 Dec 20. doi: 10.1186/s13058-021-01496-7
PMCID:
PMC8691018
AbstractArticlePDF–1.4M
5.
Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi
Emery Di Cicco, Carla Moran, W. Edward Visser, Annarita Nappi, Erik Schoenmakers, Pamela Todd, Greta Lyons, Mehul Dattani, Raffaele Ambrosio, Silvia Parisi, Domenico Salvatore, Krishna Chatterjee, Monica Dentice
Thyroid. July 2021; 31(7): 1114–1126. Published online 2021 Jul 8. doi: 10.1089/thy.2020.0391
PMCID:
PMC8290313
AbstractArticlePDF–2.1M
6.
A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2
Sarah Paisdzior, Ellen Knierim, Gunnar Kleinau, Heike Biebermann, Heiko Krude, Rachel Straussberg, Markus Schuelke
Int J Mol Sci. 2021 May; 22(10): 5338. Published online 2021 May 19. doi: 10.3390/ijms22105338
PMCID:
PMC8159125
AbstractArticlePDF–1.1M
7.
Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor
Fatma El Zahraa A. Mohamed, Ali Omar Abdelaziz, Ahmed Hussein Kasem, Tarek Ellethy, Mariana F. Gayyed
Sci Rep. 2021; 11: 7944. Published online 2021 Apr 12. doi: 10.1038/s41598-021-86754-6
PMCID:
PMC8042004
AbstractArticlePDF–1.6M
8.
Life Without Thyroid Hormone Receptor
Yun-Bo Shi
Endocrinology. 2021 Apr; 162(4): bqab028. Published online 2021 Feb 9. doi: 10.1210/endocr/bqab028
PMCID:
PMC7947273
AbstractArticle
9.
Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer
Hantao Wang, Junjie Xing, Wei Wang, Guifen Lv, Haiyan He, Yeqing Lu, Mei Sun, Haiyan Chen, Xu Li
Front Cell Dev Biol. 2020; 8: 601502. Published online 2021 Feb 11. doi: 10.3389/fcell.2020.601502
PMCID:
PMC7905040
AbstractArticlePDF–3.2M
10.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
11.
先天性甲状腺功能减退症患儿GNAS和THRA基因突变分析
陈 晓宇, 刘 勇, 刘 建华, 秦 晓松
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Jul 25; 21(7): 680–684. Chinese. doi: 10.7499/j.issn.1008-8830.2019.07.012
PMCID:
PMC7389109
AbstractArticlePDF–1.2M
12.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
13.
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller
Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119
PMCID:
PMC6942044
AbstractArticlePDF–10M
14.
Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development
Teresa G. Krieger, Carla M. Moran, Alberto Frangini, W. Edward Visser, Erik Schoenmakers, Francesco Muntoni, Chris A. Clark, David Gadian, Wui K. Chong, Adam Kuczynski, Mehul Dattani, Greta Lyons, Alexandra Efthymiadou, Faraneh Vargha-Khadem, Benjamin D. Simons, Krishna Chatterjee, Frederick J. Livesey
Proc Natl Acad Sci U S A. 2019 Nov 5; 116(45): 22754–22763. Published online 2019 Oct 18. doi: 10.1073/pnas.1908762116
Correction in:
Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7537–7538.
PMCID:
PMC6842615
AbstractArticlePDF–2.5M
15.
Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes
Valentina Benedetti, Angelo Michele Lavecchia, Monica Locatelli, Valerio Brizi, Daniela Corna, Marta Todeschini, Rubina Novelli, Ariela Benigni, Carlamaria Zoja, Giuseppe Remuzzi, Christodoulos Xinaris
JCI Insight. 2019 Sep 19; 4(18): e130249. Published online 2019 Sep 19. doi: 10.1172/jci.insight.130249
PMCID:
PMC6795387
AbstractArticlePDF–44M
16.
Acetylation modulates thyroid hormone receptor intracellular localization and intranuclear mobility
Cyril S. Anyetei-Anum, Rochelle M. Evans, Amanda M. Back, Vincent R. Roggero, Lizabeth A. Allison
Mol Cell Endocrinol. Author manuscript; available in PMC 2020 Sep 15.
Published in final edited form as: Mol Cell Endocrinol. 2019 Sep 15; 495: 110509. Published online 2019 Jul 15. doi: 10.1016/j.mce.2019.110509
PMCID:
PMC6708479
AbstractArticlePDF–1.8M
17.
IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3
Janaina S. de Souza, Cassiano Carromeu, Laila B. Torres, Bruno H. S. Araujo, Fernanda R. Cugola, Rui M.B. Maciel, Alysson R. Muotri, Gisele Giannocco
Hum Mol Genet. 2017 Jan 15; 26(2): 270–281. Published online 2016 Nov 30. doi: 10.1093/hmg/ddw384
PMCID:
PMC6075524
AbstractArticlePDF–567K
18.
Resistance to Thyroid Hormone due to a mutation in thyroid hormone receptor a1 and the a2 variant protein
Carla Moran, Maura Agostini, W. Edward Visser, Erik Schoenmakers, Nadia Schoenmakers, Amaka C. Offiah, Ken Poole, Odelia Rajanayagam, Greta Lyons, David Halsall, Mark Gurnell, Dionisios Chrysis, Alexandra Efthymiadou, Charles Buchanan, Simon Aylwin, Krishna Chatterjee
Lancet Diabetes Endocrinol. Author manuscript; available in PMC 2018 Jun 6.
Published in final edited form as: Lancet Diabetes Endocrinol. 2014 Aug; 2(8): 619–626. Published online 2014 Jun 23. doi: 10.1016/S2213-8587(14)70111-1
PMCID:
PMC5989926
AbstractArticlePDF–1.3M
19.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
20.
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114
PMCID:
PMC5495225
AbstractArticlePDF–1.3M

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