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Items: 1 to 20 of 60

1.
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang
Mol Cancer. 2023; 22: 72. Published online 2023 Apr 22. doi: 10.1186/s12943-023-01773-3
PMCID:
PMC10122405
AbstractArticlePDF–12M
2.
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
Yuichi Watanabe, Takashi Sasaki, Shoko Miyoshi, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato
J Biol Chem. 2021 Aug; 297(2): 100989. Published online 2021 Jul 21. doi: 10.1016/j.jbc.2021.100989
PMCID:
PMC8363831
AbstractArticlePDF–2.7M
3.
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway
Zu-Guo Zheng, Si-Tong Zhu, Hui-Min Cheng, Xin Zhang, Gang Cheng, Pyone Myat Thu, Supeng Perry Wang, Hui-Jun Li, Ming Ding, Lei Qiang, Xiao-Wei Chen, Qing Zhong, Ping Li, Xiaojun Xu
Autophagy. 2021; 17(7): 1592–1613. Published online 2020 May 20. doi: 10.1080/15548627.2020.1757955
PMCID:
PMC8354609
AbstractArticlePDF–14M
4.
The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity
Flaminia Ferri, Simone Carotti, Guido Carpino, Monica Mischitelli, Alfredo Cantafora, Antonio Molinaro, Maria Eva Argenziano, Simona Parisse, Alessandro Corsi, Mara Riminucci, Quirino Lai, Gianluca Mennini, Gustavo Spadetta, Francesco Pugliese, Massimo Rossi, Sergio Morini, Eugenio Gaudio, Stefano Ginanni Corradini
Int J Mol Sci. 2021 Jun; 22(11): 6100. Published online 2021 Jun 5. doi: 10.3390/ijms22116100
PMCID:
PMC8200978
AbstractArticlePDF–1.3M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig
Mol Metab. 2021 Jun; 48: 101210. Published online 2021 Mar 17. doi: 10.1016/j.molmet.2021.101210
PMCID:
PMC8094910
AbstractArticlePDF–3.1M
7.
Erratum: Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner
E Theusch, K Kim, K Stevens, J D Smith, Y-DI Chen, J I Rotter, D A Nickerson, M W Medina
Pharmacogenomics J. 2016; 16(3): 301. Published online 2016 May 20. doi: 10.1038/tpj.2016.30
Corrects:
Pharmacogenomics J. 2017 Jun; 17(3): 222–229.
PMCID:
PMC7608431
CorrectionPDF–89K
8.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
9.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
10.
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
Anke Loregger, Matthijs Raaben, Joppe Nieuwenhuis, Josephine M. E. Tan, Lucas T. Jae, Lisa G. van den Hengel, Sebastian Hendrix, Marlene van den Berg, Saskia Scheij, Ji-Ying Song, Ivo J. Huijbers, Lona J. Kroese, Roelof Ottenhoff, Michel van Weeghel, Bart van de Sluis, Thijn Brummelkamp, Noam Zelcer
Nat Commun. 2020; 11: 1128. Published online 2020 Feb 28. doi: 10.1038/s41467-020-14811-1
PMCID:
PMC7048761
AbstractArticlePDF–3.0M
11.
Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China
Jing Tao, Mayila Abudoukelimu, Xin Shen, Jun Liu, Feng-xia Wang, Jie Yuan, Pei-Pei Gu, Wei Zhu, Xiao-tian Zhang, Zhao Wang, Yi-tong Ma, Guo-qing Li
Biosci Rep. 2019 Dec 20; 39(12): BSR20190498. Published online 2019 Nov 28. doi: 10.1042/BSR20190498
PMCID:
PMC6893165
AbstractArticlePDF–447K
12.
Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8
You Zhang, Jing Lu, Jing Ma, Xinqi Liu
J Biol Chem. 2019 Feb 8; 294(6): 2046–2059. Published online 2018 Dec 18. doi: 10.1074/jbc.RA118.004630
PMCID:
PMC6369274
AbstractArticlePDF–4.0M
13.
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
Yamei Han, Zhimin Hu, Aoyuan Cui, Zhengshuai Liu, Fengguang Ma, Yaqian Xue, Yuxiao Liu, Feifei Zhang, Zehua Zhao, Yanyan Yu, Jing Gao, Chun Wei, Jingya Li, Jing Fang, Jia Li, Jian-Gao Fan, Bao-Liang Song, Yu Li
Nat Commun. 2019; 10: 623. Published online 2019 Feb 7. doi: 10.1038/s41467-019-08585-4
PMCID:
PMC6367348
AbstractArticlePDF–3.0M
14.
Genome-wide CRISPR analysis identifies substrate-specific conjugation modules in ER-associated degradation
Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher P. Walczak, Joshua E. Elias, Michael C. Bassik, Ron R. Kopito
Mol Cell. Author manuscript; available in PMC 2020 Jan 17.
Published in final edited form as: Mol Cell. 2019 Jan 17; 73(2): 377–389.e11. Published online 2018 Dec 20. doi: 10.1016/j.molcel.2018.11.015
PMCID:
PMC6338494
AbstractArticlePDF–1.9M
15.
HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages
Alexander N. Orekhov, Tatiana Pushkarsky, Yumiko Oishi, Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth, Igor A. Sobenin, Vasily N. Sukhorukov, Emile R. Zakiev, Anatol Kontush, Wilfried Le Goff, Michael Bukrinsky
Exp Mol Pathol. Author manuscript; available in PMC 2019 Oct 1.
Published in final edited form as: Exp Mol Pathol. 2018 Oct; 105(2): 202–207. Published online 2018 Aug 16. doi: 10.1016/j.yexmp.2018.08.003
PMCID:
PMC6247801
AbstractArticlePDF–563K
16.
Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase
Lu-Yi Jiang, Wei Jiang, Na Tian, Yan-Ni Xiong, Jie Liu, Jian Wei, Kai-Yue Wu, Jie Luo, Xiong-Jie Shi, Bao-Liang Song
J Biol Chem. 2018 Mar 16; 293(11): 4047–4055. Published online 2018 Jan 26. doi: 10.1074/jbc.RA117.001260
PMCID:
PMC5857978
AbstractArticlePDF–2.6M
17.
Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage
Kara L. Norman, Tzu-Chun Chen, Gusti Zeiner, Peter Sarnow
RNA. 2017 Dec; 23(12): 1886–1893. doi: 10.1261/rna.063099.117
PMCID:
PMC5689008
AbstractArticlePDF–1.6M
18.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
19.
Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation
Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong, Shu-Yuan Guo, Hui-Yong Yin, Xu Lin, Qin Li, Catherine CY Chang, Ta-Yuan Chang, Bo-Liang Li, Bao-Liang Song
Nat Cell Biol. Author manuscript; available in PMC 2017 Dec 12.
Published in final edited form as: Nat Cell Biol. 2017 Jul; 19(7): 808–819. Published online 2017 Jun 12. doi: 10.1038/ncb3551
Correction in:
Nat Cell Biol. 2017 Nov 29; 19(12): 1441.
PMCID:
PMC5518634
AbstractArticlePDF–1.3M
20.
HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model
Barbara Schrörs, Silke Lübcke, Volker Lennerz, Martina Fatho, Anne Bicker, Catherine Wölfel, Patrick Derigs, Thomas Hankeln, Dirk Schadendorf, Annette Paschen, Thomas Wölfel
Oncotarget. 2017 Apr 25; 8(17): 28312–28327. Published online 2017 Mar 9. doi: 10.18632/oncotarget.16048
PMCID:
PMC5438652
AbstractArticlePDF–5.9M

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