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Select item 100729061.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 96413122.

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P. Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J. Pelham, Andrés Augusto Arias, Taushif Khan, Manar Ata, Fatima Al Ali, Flore Rozenberg, Xiao-Fei Kong, Maya Chrabieh, Candice Laine, Wei-Te Lei, Ji Eun Han, Yoann Seeleuthner, Zenia Kaul, Emmanuelle Jouanguy, Vivien Béziat, Leila Youssefian, Hassan Vahidnezhad, V. Koneti Rao, Bénédicte Neven, Claire Fieschi, Davood Mansouri, Mohammad Shahrooei, Sevgi Pekcan, Gulsum Alkan, Melike Emiroğlu, Hüseyin Tokgöz, Jouni Uitto, Fabian Hauck, Jacinta Bustamante, Laurent Abel, Sevgi Keles, Nima Parvaneh, Nico Marr, Pamela L. Schwartzberg, Sylvain Latour, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis

J Exp Med. 2023 Jan 2; 220(1): e20220484. Published online 2022 Nov 3. doi: 10.1084/jem.20220484

PMCID:: PMC9641312

Abstract Article PDF–7.9M

Select item 88734793.

ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Jessica Elmore, Chavez Carter, Amie Redko, Nicholas Koylass, Amelia Bennett, Max Mead, Marinel Ocasio-Rivera, Weishan Huang, Ankur Singh, Avery August

Commun Biol. 2022; 5: 162. Published online 2022 Feb 24. doi: 10.1038/s42003-022-03109-1

PMCID:: PMC8873479

Abstract Article PDF–2.0M

Select item 85492764.

Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR screen could predict prognosis of ovarian cancer patients with distant metastasis

Mengyao Xu, Shan Huang, Jiahui Chen, Wanxue Xu, Rong Xiang, Yongjun Piao, Shuangtao Zhao

J Transl Med. 2021; 19: 447. Published online 2021 Oct 26. doi: 10.1186/s12967-021-03119-3

PMCID:: PMC8549276

Abstract Article PDF–7.6M

Select item 83516955.

Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma

Binhua Pan, Modan Yang, Xuyong Wei, Wangyao Li, Kun Wang, Mengfan Yang, Di Lu, Rui Wang, Beini Cen, Xiao Xu

Aging (Albany NY) 2021 Jul 31; 13(14): 18620–18644. Published online 2021 Jul 19. doi: 10.18632/aging.203306

PMCID:: PMC8351695

Abstract Article PDF–5.2M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81130887.

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

Enas Hallumi, Rose Shalah, Wan-Lin Lo, Jasmin Corso, Ilana Oz, Dvora Beach, Samuel Wittman, Amy Isenberg, Meirav Sela, Henning Urlaub, Arthur Weiss, Deborah Yablonski

J Immunol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: J Immunol. 2021 May 15; 206(10): 2322–2337. Published online 2021 Apr 30. doi: 10.4049/jimmunol.2001053

PMCID:: PMC8113088

Abstract Article PDF–2.7M

Select item 77796618.

ITK deficiency presenting as Autoimmune Lymphoproliferative Syndrome

Jacqueline G Wallace, Mohammed Alosaimi, Claudia Djambas Khayat, Faris Jaber, Abduarahman Almutairi, Sarah Beaussant-Cohen, Geraldine Pinkus, Mark Fleming, Cybel Mehawej, Janet Chou, Raif S Geha

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Feb; 147(2): 743–745.e1. Published online 2020 Jul 4. doi: 10.1016/j.jaci.2020.06.019

PMCID:: PMC7779661

Abstract Article PDF–777K

Select item 76441649.

SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer

Yin Peng, Xiaojing Zhang, Huijuan Lin, Shiqi Deng, Ying Qin, Yuan Yuan, Xianling Feng, Jian Wang, wangchun Chen, Fan Hu, Ruibin Yan, Yanqiu Zhao, Yulan Cheng, Yanjie Wei, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Song Li, Stephen J. Meltzer, Zhe Jin

Cell Cycle. 2020; 19(20): 2720–2733. Published online 2020 Oct 5. doi: 10.1080/15384101.2020.1826632

Correction in:: Cell Cycle. 2021; 20(4): 461–464.

PMCID:: PMC7644164

Abstract Article PDF–5.8M

Select item 742732710.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 736155011.

BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy

Michael C McGee, Avery August, Weishan Huang

J Leukoc Biol. 2021 Jan; 109(1): 49–53. Published online 2020 Jul 8. doi: 10.1002/JLB.5COVR0620-306R

PMCID:: PMC7361550

Abstract Article PDF–567K

Select item 731727912.

Inherited Interleukin 2–Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma

Leila Youssefian, Hassan Vahidnezhad, Mehdi Yousefi, Amir Hossein Saeidian, Arghavan Azizpour, Andrew Touati, Neda Nikbakht, Kambiz Kamyab- Hesari, Mohammad Mahdi Adib-Sereshki, Sirous Zeinali, Behzad Mansoori, Ali Jazayeri, Razieh Karamzadeh, Paolo Fortina, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto

Clin Infect Dis. 2019 Jun 1; 68(11): 1938–1941. Published online 2019 Feb 19. doi: 10.1093/cid/ciy942

PMCID:: PMC7317279

Abstract Article PDF–9.0M

Select item 715369513.

ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008

PMCID:: PMC7153695

Abstract Article PDF–2.6M

Select item 680250614.

The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein

Thorny Cesilie Bie Andersen, Per Eugen Kristiansen, Zsuzsa Huszenicza, Maria U. Johansson, Ramakrishna Prabhu Gopalakrishnan, Hanna Kjelstrup, Scott Boyken, Vibeke Sundvold-Gjerstad, Stine Granum, Morten Sørli, Paul Hoff Backe, D. Bruce Fulton, B. Göran Karlsson, Amy H. Andreotti, Anne Spurkland

J Biol Chem. 2019 Oct 18; 294(42): 15480–15494. Published online 2019 Sep 4. doi: 10.1074/jbc.RA119.008318

PMCID:: PMC6802506

Abstract Article PDF–2.2M

Select item 677813715.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9