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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 107820242.

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Shuzhen Liu, Preston Perez, Xue Sun, Ken Chen, Rojin Fatirkhorani, Jamila Mammadova, Zhigao Wang

Cell Death Differ. 2024 Jan; 31(1): 40–52. Published online 2023 Nov 23. doi: 10.1038/s41418-023-01237-7

PMCID:: PMC10782024

Abstract Article PDF–11M

Select item 106931303.

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi Li

Mol Neurodegener. 2023; 18: 94. Published online 2023 Dec 1. doi: 10.1186/s13024-023-00686-5

PMCID:: PMC10693130

Abstract Article PDF–8.9M

Select item 106172094.

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin

Mol Brain. 2023; 16: 74. Published online 2023 Oct 30. doi: 10.1186/s13041-023-01064-4

PMCID:: PMC10617209

Abstract Article PDF–6.5M

Select item 106031355.

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

Yanxiang Meng, Sarah E. Garnish, Katherine A. Davies, Katrina A. Black, Andrew P. Leis, Christopher R. Horne, Joanne M. Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N. Young, Toby Dite, Laura F. Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E. Czabotar, James M. Murphy

Nat Commun. 2023; 14: 6804. Published online 2023 Oct 26. doi: 10.1038/s41467-023-42255-w

PMCID:: PMC10603135

Abstract Article PDF–3.2M

Select item 105393406.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand

Nat Commun. 2023; 14: 6046. Published online 2023 Sep 28. doi: 10.1038/s41467-023-41724-6

PMCID:: PMC10539340

Abstract Article PDF–2.6M

Select item 104069017.

Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order

Mohammad Ekhlak, Paresh P. Kulkarni, Vipin Singh, Susheel N. Chaurasia, Saroj Kant Mohapatra, Rameshwar Nath Chaurasia, Debabrata Dash

Cell Death Differ. 2023 Aug; 30(8): 1886–1899. Published online 2023 Jun 10. doi: 10.1038/s41418-023-01181-6

PMCID:: PMC10406901

Abstract Article PDF–4.6M

Select item 103973468.

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu

Commun Biol. 2023; 6: 805. Published online 2023 Aug 2. doi: 10.1038/s42003-023-05166-6

PMCID:: PMC10397346

Abstract Article PDF–3.5M

Select item 102443839.

IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death

Choong-Sil Lee, Gyuho Hwang, Young Woo Nam, Chi Hyun Hwang, Jaewhan Song

Cell Death Differ. 2023 Jun; 30(6): 1575–1584. Published online 2023 Apr 21. doi: 10.1038/s41418-023-01161-w

PMCID:: PMC10244383

Abstract Article PDF–2.8M

Select item 1022485310.

Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia

Amany M. Kamal, Nermeen A. Nabih, Nahed M. Rakha, Eman F. Sanad

Clin Exp Med. 2023; 23(2): 447–456. Published online 2022 Jun 14. doi: 10.1007/s10238-022-00839-8

PMCID:: PMC10224853

Abstract Article PDF–1.1M

Select item 1012768511.

MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection

Xuqiu Lei, Yongzhi Chen, Egil Lien, Katherine A. Fitzgerald

mBio. 2023 Mar-Apr; 14(2): e00110-23. Published online 2023 Feb 28. doi: 10.1128/mbio.00110-23

PMCID:: PMC10127685

Abstract Article PDF–1.2M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 984420213.

SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses

Shufen Li, Yulan Zhang, Zhenqiong Guan, Meidi Ye, Huiling Li, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Fan Zhang, Ben Lu, Peng Zhou, Ke Peng

Cell Res. 2023 Mar; 33(3): 201–214. Published online 2023 Jan 17. doi: 10.1038/s41422-022-00775-y

PMCID:: PMC9844202

Abstract Article PDF–6.5M

Select item 971576514.

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy

Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura

ESC Heart Fail. 2022 Oct; 9(5): 3435–3451. Published online 2022 Jul 18. doi: 10.1002/ehf2.14059

PMCID:: PMC9715765

Abstract Article PDF–44M

Select item 943343015.

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley, James M. Murphy

Cell Death Differ. 2022 Sep; 29(9): 1804–1815. Published online 2022 Mar 9. doi: 10.1038/s41418-022-00965-6

PMCID:: PMC9433430

Abstract Article PDF–3.6M

Select item 910523516.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 902298017.

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

Sarah E. Garnish, Joanne M. Hildebrand

Biochem Soc Trans. 2022 Feb 28; 50(1): 529–539. Published online 2022 Feb 15. doi: 10.1042/BST20210517

PMCID:: PMC9022980

Abstract Article PDF–4.3M

Select item 891534318.

Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3⁺ and CD8⁺ T cell density and predict prognosis in hepatocellular carcinoma

Lorenzo Nicolè, Tiziana Sanavia, Rocco Cappellesso, Valeria Maffeis, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Claudia Maria Radu, Paolo Simioni, Davide Serafin, Giuliana Cortese, Maria Guido, Giacomo Zanus, Hirohisa Yano, Ambrogio Fassina

J Immunother Cancer. 2022; 10(3): e004031. Published online 2022 Mar 8. doi: 10.1136/jitc-2021-004031

PMCID:: PMC8915343

Abstract Article PDF–5.0M

Select item 881694419.

Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes

Seongmin Yoon, Konstantin Bogdanov, David Wallach

Cell Death Differ. 2022 Feb; 29(2): 306–322. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00924-7

PMCID:: PMC8816944

Abstract Article PDF–5.4M

Select item 860879620.

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy

Nat Commun. 2021; 12: 6783. Published online 2021 Nov 22. doi: 10.1038/s41467-021-27032-x

PMCID:: PMC8608796

Abstract Article PDF–6.8M

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