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Items: 1 to 20 of 39

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet β Cells
Xiuhong Lin, Lin Cheng, Yan Wan, Yuerong Yan, Zhuo Zhang, Xiaohui Li, Jiayun Wu, Xiaoyi Wang, Mingtong Xu
Endocr Metab Immune Disord Drug Targets. 2023 Jul 19; 23(9): 1186–1200. Published online 2023 Jul 19. doi: 10.2174/1871530323666230206121715
PMCID:
PMC10514520
AbstractArticlePDF–3.3M
3.
Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly
Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng
Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y
PMCID:
PMC10021989
AbstractArticlePDF–1.5M
4.
mTORC2 Controls PKC and Akt by Phosphorylating a Conserved TOR-Interaction Motif
Timothy R. Baffi, Gema Lordén, Jacob M. Wozniak, Andreas Feichtner, Wayland Yeung, Alexandr P. Kornev, Charles C. King, Jason C. Del Rio, Ameya J. Limaye, Julius Bogomolovas, Christine M. Gould, Ju Chen, Eileen J. Kennedy, Natarajan Kannan, David J. Gonzalez, Eduard Stefan, Susan S. Taylor, Alexandra C. Newton
Sci Signal. Author manuscript; available in PMC 2021 Jun 16.
Published in final edited form as: Sci Signal. 2021 Apr 13; 14(678): eabe4509. Published online 2021 Apr 13. doi: 10.1126/scisignal.abe4509
PMCID:
PMC8208635
AbstractArticlePDF–3.2M
5.
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
Man Li, Adam S. Lazorchak, Xinxing Ouyang, Huihui Zhang, Hongzhi Liu, Omotooke A. Arojo, Lichong Yan, Jingsi Jin, Yuheng Han, Guojun Qu, Yuhong Fu, Xiaocao Xu, Xiaobo Liu, Wenqian Zhang, Zhengfeng Yang, Chuan Ruan, Qijun Wang, Dou Liu, Chuanxin Huang, Lu Lu, Shibo Jiang, Fubin Li, Bing Su
Cell Mol Immunol. 2019 Sep; 16(9): 757–769. Published online 2019 Jan 31. doi: 10.1038/s41423-018-0185-x
PMCID:
PMC6804816
AbstractArticlePDF–1.7M
6.
Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2
Xinxing Ouyang, Yuheng Han, Guojun Qu, Man Li, Ningbo Wu, Hongzhi Liu, Omotooke Arojo, Hongxiang Sun, Xiaobo Liu, Dou Liu, Lei Chen, Qiang Zou, Bing Su
J Mol Cell Biol. 2019 Feb; 11(2): 93–106. Published online 2018 Nov 14. doi: 10.1093/jmcb/mjy065
PMCID:
PMC6392101
AbstractArticlePDF–1.5M
7.
Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma
Qing Wang, Jiang Zhu, Ya-Wen Wang, Yong Dai, Yanlei Wang, Chi Wang, Jinpeng Liu, Alyson Baker, Nancy H. Colburn, Hsin-Sheng Yang
Oncogene. Author manuscript; available in PMC 2018 Jan 10.
Published in final edited form as: Oncogene. 2017 Nov 9; 36(45): 6225–6234. Published online 2017 Jul 10. doi: 10.1038/onc.2017.228
PMCID:
PMC5680133
AbstractArticlePDF–3.1M
8.
Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses
Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor N. Fish, Leonidas C. Platanias
J Biol Chem. 2017 Mar 17; 292(11): 4743–4752. Published online 2017 Feb 7. doi: 10.1074/jbc.M116.757666
PMCID:
PMC5377787
AbstractArticlePDF–1.1M
9.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
10.
Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival
Laura J. Smithson, David H. Gutmann
Genes Dev. 2016 Jun 15; 30(12): 1383–1388. doi: 10.1101/gad.279661.116
PMCID:
PMC4926861
AbstractArticlePDF–500K
11.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
12.
Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses
Surinder Kaur, Barbara Kroczynska, Bhumika Sharma, Antonella Sassano, Ahmet Dirim Arslan, Beata Majchrzak-Kita, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Bing Su, Raffaele A. Calogero, Eleanor N. Fish, Leonidas C. Platanias
J Biol Chem. 2014 Mar 7; 289(10): 6581–6591. Published online 2014 Jan 27. doi: 10.1074/jbc.M113.537852
PMCID:
PMC3945321
AbstractArticlePDF–1.9M
13.
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu, Min Yuan, Byeong Mo Kim, Shavali Shaik, Suchithra Menon, Steven P. Gygi, Tae Ho Lee, John M Asara, Brendan D. Manning, John Blenis, Bing Su, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2014 May 1.
Published in final edited form as: Nat Cell Biol. 2013 Nov; 15(11): 1340–1350. Published online 2013 Oct 27. doi: 10.1038/ncb2860
PMCID:
PMC3827117
AbstractArticlePDF–1.6M
14.
Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2
Gretchen A. LaRusch, Alona Merkulova, Fakhri Mahdi, Zia Shariat-Madar, Robert G. Sitrin, Douglas B. Cines, Alvin H. Schmaier
Am J Physiol Heart Circ Physiol. 2013 Aug 1; 305(3): H305–H320. Published online 2013 May 24. doi: 10.1152/ajpheart.00110.2013
PMCID:
PMC3742872
AbstractArticle
15.
Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
Sean J. Humphrey, Guang Yang, Pengyi Yang, Daniel J. Fazakerley, Jacqueline Stöckli, Jean Y. Yang, David E. James
Cell Metab. 2013 Jun 4; 17(6): 1009–1020. doi: 10.1016/j.cmet.2013.04.010
PMCID:
PMC3690479
AbstractArticlePDF–3.9M
16.
Sin1 regulates Treg development but is not required for T cell growth and proliferation
Xing Chang, Adam S. Lazorchak, Dou Liu, Bing Su
Eur J Immunol. Author manuscript; available in PMC 2013 Jun 1.
Published in final edited form as: Eur J Immunol. 2012 Jun; 42(6): 1639–1647. doi: 10.1002/eji.201142066
PMCID:
PMC3663871
AbstractArticlePDF–1.0M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
Sung Jin Kim, Michael A. DeStefano, Won Jun Oh, Chang-chih Wu, Nicole M. Vega-Cotto, Monica Finlan, Dou Liu, Bing Su, Estela Jacinto
Mol Cell. Author manuscript; available in PMC 2013 Dec 28.
Published in final edited form as: Mol Cell. 2012 Dec 28; 48(6): 875–887. Published online 2012 Nov 8. doi: 10.1016/j.molcel.2012.09.029
PMCID:
PMC3534931
AbstractArticlePDF–3.7M
19.
PRR5L degradation promotes MTORC2-mediated PKCd phosphorylation and cell migration downstream of Ga12
Xiaoqing Gan, Jiyong Wang, Chen Wang, Eeva Sommer, Tohru Kozasa, Srinivasa Srinivasula, Dario Alessi, Stefan Offermanns, Melvin I. Simon, Dianqing Wu
Nat Cell Biol. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as: Nat Cell Biol. 2012 Jul; 14(7): 686–696. Published online 2012 May 20. doi: 10.1038/ncb2507
PMCID:
PMC3389271
AbstractArticlePDF–2.6M
20.
Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses
Surinder Kaur, Antonella Sassano, Beata Majchrzak-Kita, Darren P. Baker, Bing Su, Eleanor N. Fish, Leonidas C. Platanias
Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7723–7728. Published online 2012 May 1. doi: 10.1073/pnas.1118122109
PMCID:
PMC3356630
AbstractArticlePDF–1.7M

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