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Items: 1 to 20 of 177

1.
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
Margaret Solon, Nianfeng Ge, Shannon Hambro, Susan Haller, Jian Jiang, Miriam Baca, Jessica Preston, Allie Maltzman, Katherine E. Wickliffe, Yuxin Liang, Rohit Reja, Dorothee Nickles, Kim Newton, Joshua D. Webster
Cell Death Differ. 2024 May; 31(5): 672–682. Published online 2024 Mar 28. doi: 10.1038/s41418-024-01286-6
PMCID:
PMC11093969
AbstractArticlePDF–5.5M
2.
Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model
Phoebe Ohene-Marfo, Hoang Van M. Nguyen, Sabira Mohammed, Nidheesh Thadathil, Albert Tran, Evan H. Nicklas, Dawei Wang, Ramasamy Selvarani, Jacob W. Farriester, Rohan Varshney, Michael Kinter, Arlan Richardson, Michael C. Rudolph, Sathyaseelan S. Deepa
Int J Mol Sci. 2024 Mar; 25(5): 2813. Published online 2024 Feb 28. doi: 10.3390/ijms25052813
PMCID:
PMC10931720
AbstractArticlePDF–3.4M
3.
RIP3/MLKL通过激活4EBP1-eIF4E通路诱导程序性坏死
王 树超, 徐 玫丽
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Jul 28; 48(7): 979–985. Chinese. doi: 10.11817/j.issn.1672-7347.2023.230153
PMCID:
PMC10930047
AbstractArticlePDF–2.0M
4.
Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors
Layla Shojaie, Jacob M. Bogdanov, Helia Alavifard, Mahmoud G. Mohamed, Aria Baktash, Myra Ali, Simeon Mahov, Sue Murray, Gary C. Kanel, Zhang-Xu Liu, Fumito Ito, Gino K. In, Akil Merchant, William Stohl, Lily Dara
Cell Death Dis. 2024 Feb; 15(2): 140. Published online 2024 Feb 14. doi: 10.1038/s41419-024-06535-7
PMCID:
PMC10866933
AbstractArticlePDF–10M
5.
Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation
Xu Yang, Guilin Li, Pengbo Lou, Mingxin Zhang, Kai Yao, Jintao Xiao, Yiqian Chen, Jiuzhi Xu, Shengyuan Tian, Min Deng, Yuwei Pan, Mengzhen Li, Xi Wu, Ruiqi Liu, Xiaojing Shi, Yuhua Tian, Lu Yu, Hao Ke, Baowei Jiao, Yingzi Cong, Maksim V. Plikus, Xiaowei Liu, Zhengquan Yu, Cong Lv
Proc Natl Acad Sci U S A. 2024 Jan 2; 121(1): e2307395120. Published online 2023 Dec 29. doi: 10.1073/pnas.2307395120
PMCID:
PMC10769860
AbstractArticlePDF–6.6M
6.
The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation
Yu-Xin Lei, Yang Liu, Li-Hua Xing, Yu-Jing Wu, Xue-Yin Wang, Fan-Hua Meng, Ya-Nan Lou, Zhao-Guo Ma, Lin Yuan, Shui-Xing Yu
Virulence. 2023; 14(1): 2258057. Published online 2023 Sep 24. doi: 10.1080/21505594.2023.2258057
PMCID:
PMC10732671
AbstractArticlePDF–7.2M
7.
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi Li
Mol Neurodegener. 2023; 18: 94. Published online 2023 Dec 1. doi: 10.1186/s13024-023-00686-5
PMCID:
PMC10693130
AbstractArticlePDF–8.9M
8.
Dynamics of necroptosis in kidney ischemia-reperfusion injury
Aspasia Pefanis, Anjan K. Bongoni, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, James M. Murphy, Francesco L. Ierino, Peter J. Cowan
Front Immunol. 2023; 14: 1251452. Published online 2023 Nov 2. doi: 10.3389/fimmu.2023.1251452
PMCID:
PMC10652410
AbstractArticlePDF–1.7M
9.
Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases
Ramasamy Selvarani, Hoang Van Michelle Nguyen, Nidheesh Thadathil, Roman F. Wolf, Willard M. Freeman, Christopher D. Wiley, Sathyaseelan S. Deepa, Arlan Richardson
GeroScience. 2023 Dec; 45(6): 3241–3256. Published online 2023 Oct 4. doi: 10.1007/s11357-023-00955-7
PMCID:
PMC10643444
AbstractArticlePDF–1.7M
10.
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Nat Commun. 2023; 14: 6046. Published online 2023 Sep 28. doi: 10.1038/s41467-023-41724-6
PMCID:
PMC10539340
AbstractArticlePDF–2.6M
11.
Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation
Han Meng, Youyi Zhao, Yuqian Li, Hong Fan, Xuyang Yi, Xinyu Meng, Pengfei Wang, Fanfan Fu, Shengxi Wu, Yazhou Wang
Front Cell Dev Biol. 2023; 11: 1229788. Published online 2023 Jul 27. doi: 10.3389/fcell.2023.1229788
PMCID:
PMC10416103
AbstractArticlePDF–3.6M
12.
Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis
Mengli Yan, Hui Li, Shiyu Xu, Jinyan Wu, Jiachen Li, Chengju Xiao, Chunheng Mo, Bi-Sen Ding
Int J Mol Sci. 2023 Jul; 24(14): 11313. Published online 2023 Jul 11. doi: 10.3390/ijms241411313
PMCID:
PMC10379228
AbstractArticlePDF–11M
13.
MLKL deficiency protects against low-grade, sterile inflammation in aged mice
Emma C. Tovey Crutchfield, Sarah E. Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M. Patel, Pradnya Gangatirkar, Katherine R. Martin, Connie S. N. Li Wai Suen, Alexandra L. Garnham, Andrew J. Kueh, Ian P. Wicks, John Silke, Ueli Nachbur, Andre L. Samson, James M. Murphy, Joanne M. Hildebrand
Cell Death Differ. 2023 Apr; 30(4): 1059–1071. Published online 2023 Feb 8. doi: 10.1038/s41418-023-01121-4
PMCID:
PMC10070424
AbstractArticlePDF–6.1M
14.
Cigarette smoke depletes alveolar macrophages and delays clearance of Legionella pneumophila
Markus Fleischmann, Andrew G. Jarnicki, Andrew S. Brown, Chao Yang, Gary P. Anderson, Natalio Garbi, Elizabeth L. Hartland, Ian R. van Driel, Garrett Z. Ng
Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1; 324(3): L373–L384. Published online 2023 Jan 31. doi: 10.1152/ajplung.00268.2022
PMCID:
PMC10026984
AbstractArticle
15.
Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
Brian Montoya, Cory J. Knudson, Carolina R. Melo-Silva, Lingjuan Tang, Samita Kafle, Luis J. Sigal
J Virol. 2023 Feb; 97(2): e01945-22. Published online 2023 Jan 18. doi: 10.1128/jvi.01945-22
PMCID:
PMC9973014
AbstractArticlePDF–2.7M
16.
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
Cheng Peng, Guangping Tu, Jiale Wang, Yilin Wang, Peng Wu, Li Yu, Zhiqiang Li, Xiao Yu
Cell Death Dis. 2023 Feb; 14(2): 155. Published online 2023 Feb 24. doi: 10.1038/s41419-023-05655-w
PMCID:
PMC9958014
AbstractArticlePDF–7.0M
17.
RIPK3 controls MAIT cell accumulation during development but not during infection
Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett
Cell Death Dis. 2023 Feb; 14(2): 111. Published online 2023 Feb 11. doi: 10.1038/s41419-023-05619-0
PMCID:
PMC9922319
AbstractArticlePDF–2.2M
18.
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis
Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran, Douglas R. Green
Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2207240119. Published online 2022 Oct 3. doi: 10.1073/pnas.2207240119
PMCID:
PMC9565532
AbstractArticlePDF–2.6M
19.
Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic
eLife. 2022; 11: e82766. Published online 2022 Sep 26. doi: 10.7554/eLife.82766
PMCID:
PMC9545535
AbstractArticlePDF–15M
20.
Mixed lineage kinase-like protein protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis
Yang Liu, Li-Hua Xing, Fen-Xin Li, Na Wang, Yu-Ze Ma, Jian-Wei Li, Yu-Jing Wu, Jing Liang, Yu-Xin Lei, Xue-Yin Wang, Fan-Hua Meng, Yong-Jun Yang, Guang-Peng Li, Xiao Wang, Shui-Xing Yu
iScience. 2022 Oct 21; 25(10): 105121. Published online 2022 Sep 12. doi: 10.1016/j.isci.2022.105121
Correction in:
iScience. 2023 Mar 17; 26(3): 106149.
PMCID:
PMC9515590
AbstractArticlePDF–11M

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