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Select item 110401271.

Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation

Shumin Fan, Sonam Popli, Sukanya Chakravarty, Ritu Chakravarti, Saurabh Chattopadhyay

J Biol Chem. 2024 Apr; 300(4): 107200. Published online 2024 Mar 18. doi: 10.1016/j.jbc.2024.107200

PMCID:: PMC11040127

Abstract Article PDF–3.2M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109150953.

Oral Clostridium butyricum on mice endometritis through uterine microbiome and metabolic alternations

Mao Hagihara, Tadashi Ariyoshi, Shuhei Eguchi, Kentaro Oka, Motomichi Takahashi, Hideo Kato, Yuichi Shibata, Takumi Umemura, Takeshi Mori, Narimi Miyazaki, Jun Hirai, Nobuhiro Asai, Nobuaki Mori, Hiroshige Mikamo

Front Microbiol. 2024; 15: 1351899. Published online 2024 Feb 21. doi: 10.3389/fmicb.2024.1351899

PMCID:: PMC10915095

Abstract Article PDF–2.7M

Select item 108911544.

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira do Rêgo, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Cell Death Dis. 2024 Feb; 15(2): 169. Published online 2024 Feb 23. doi: 10.1038/s41419-024-06549-1

PMCID:: PMC10891154

Abstract Article PDF–2.6M

Select item 107922455.

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

Sarah A. Kazzaz, Kashif A. Shaikh, Jesse White, Qinjie Zhou, Wade H. Powell, Edward W. Harhaj

J Biol Chem. 2024 Jan; 300(1): 105525. Published online 2023 Dec 1. doi: 10.1016/j.jbc.2023.105525

PMCID:: PMC10792245

Abstract Article PDF–2.8M

Select item 106175626.

Interferon regulatory factor 7 modulates virus clearance and immune responses to alphavirus encephalomyelitis

Elizabeth M. Troisi, Benjamin H. Nguyen, Victoria K. Baxter, Diane E. Griffin

J Virol. 2023 Oct; 97(10): e00959-23. Published online 2023 Sep 29. doi: 10.1128/jvi.00959-23

PMCID:: PMC10617562

Abstract Article PDF–2.0M

Select item 105803337.

Delayed CO₂ postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression

Yan Li, Ru Chen, Gui‐Ping Shen, Jing Yin, Yu Li, Jing Zhao, Fang Nan, Shu‐Han Zhang, Hui‐Feng Zhang, Cai‐Hong Yang, Mei‐Na Wu, Yan‐Ying Fan

CNS Neurosci Ther. 2023 Nov; 29(11): 3378–3390. Published online 2023 May 19. doi: 10.1111/cns.14268

PMCID:: PMC10580333

Abstract Article PDF–10M

Select item 105472078.

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo

Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli

PLoS Pathog. 2023 Sep; 19(9): e1011446. Published online 2023 Sep 21. doi: 10.1371/journal.ppat.1011446

PMCID:: PMC10547207

Abstract Article PDF–2.4M

Select item 105150229.

Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection

Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay, Andrea Kröger

J Neuroinflammation. 2023; 20: 213. Published online 2023 Sep 22. doi: 10.1186/s12974-023-02892-w

PMCID:: PMC10515022

Abstract Article PDF–7.2M

Select item 1034155610.

TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination

Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Guie Chen, Yanqin Lai, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo

Int J Mol Sci. 2023 Jul; 24(13): 10892. Published online 2023 Jun 30. doi: 10.3390/ijms241310892

PMCID:: PMC10341556

Abstract Article PDF–2.3M

Select item 982755111.

XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7

Bao‐qin Liu, Rong‐bei Liu, Wen‐ping Li, Xin‐tao Mao, Yi‐ning Li, Tao Huang, Hao‐li Wang, Hao‐tian Chen, Jiang‐yan Zhong, Bing Yang, Ren‐jie Chai, Qian Cao, Jin Jin, Yi‐yuan Li

EMBO Rep. 2023 Jan; 24(1): e55387. Published online 2022 Nov 17. doi: 10.15252/embr.202255387

PMCID:: PMC9827551

Abstract Article PDF–3.3M

Select item 971265912.

The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

Huimei Chen, Gabriel Chew, Nithya Devapragash, Jui Zhi Loh, Kevin Y. Huang, Jing Guo, Shiyang Liu, Elisabeth Li Sa Tan, Shuang Chen, Nicole Gui Zhen Tee, Masum M. Mia, Manvendra K. Singh, Aihua Zhang, Jacques Behmoaras, Enrico Petretto

Nat Commun. 2022; 13: 7375. Published online 2022 Nov 30. doi: 10.1038/s41467-022-34971-6

PMCID:: PMC9712659

Abstract Article PDF–4.6M

Select item 947464313.

The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit

Immunity. Author manuscript; available in PMC 2023 Sep 13.

Published in final edited form as: Immunity. 2022 Aug 10 : S1074-7613(22)00340-5. Published online 2022 Aug 10. doi: 10.1016/j.immuni.2022.07.007

PMCID:: PMC9474643

Abstract Article PDF–3.6M

Select item 901028814.

Loss of IRF7 accelerates acute myeloid leukemia progression and induces VCAM1-VLA-4 mediated intracerebral invasion

Hao Wang, Dongyue Zhang, Xiaoxi Cui, Yibo Dai, Chenchen Wang, Wenli Feng, Xiaoqian Lv, Yifei Li, Lina Wang, Yongxin Ru, Yingchi Zhang, Qian Ren, Guoguang Zheng

Oncogene. 2022; 41(16): 2303–2314. Published online 2022 Mar 7. doi: 10.1038/s41388-022-02233-w

PMCID:: PMC9010288

Abstract Article PDF–5.5M

Select item 892620215.

Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses

Alyssa B. Evans, Clayton W. Winkler, Karin E. Peterson

PLoS Pathog. 2022 Mar; 18(3): e1010384. Published online 2022 Mar 4. doi: 10.1371/journal.ppat.1010384

PMCID:: PMC8926202

Abstract Article PDF–4.0M

Select item 889504816.

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response

Xinwei Geng, Chao Zhang, Miao Li, Jiaqi Wang, Fang Ji, Hanrong Feng, Meichun Xing, Fei Li, Lingling Zhang, Wen Li, Zhihua Chen, Ian D. Hickson, Huahao Shen, Songmin Ying

Adv Sci (Weinh) 2022 Mar; 9(7): 2103837. Published online 2022 Jan 17. doi: 10.1002/advs.202103837

PMCID:: PMC8895048

Abstract Article PDF–3.9M

Select item 886044017.

m6A modifications regulate intestinal immunity and rotavirus infection

Anmin Wang, Wanyiin Tao, Jiyu Tong, Juanzi Gao, Jinghao Wang, Gaopeng Hou, Chen Qian, Guorong Zhang, Runzhi Li, Decai Wang, Xingxing Ren, Kaiguang Zhang, Siyuan Ding, Richard A Flavell, Huabing Li, Wen Pan, Shu Zhu

eLife. 2022; 11: e73628. Published online 2022 Jan 31. doi: 10.7554/eLife.73628

PMCID:: PMC8860440

Abstract Article PDF–3.5M

Select item 885366218.

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice

eLife. 2022; 11: e74072. Published online 2022 Feb 9. doi: 10.7554/eLife.74072

PMCID:: PMC8853662

Abstract Article PDF–21M

Select item 868669019.

Genome Instability Independent of Type I Interferon Signaling Drives Neuropathology Caused by Impaired Ribonucleotide Excision Repair

Aditi, Susanna M. Downing, Patrick A. Schreiner, Young Don Kwak, Yang Li, Timothy I. Shaw, Helen R. Russell, Peter J. McKinnon

Neuron. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Neuron. 2021 Dec 15; 109(24): 3962–3979.e6. Published online 2021 Oct 15. doi: 10.1016/j.neuron.2021.09.040

PMCID:: PMC8686690

Abstract Article PDF–4.1M

Select item 825596320.

Cellular nucleic acid–binding protein is essential for type I interferon–mediated immunity to RNA virus infection

Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, Katherine A. Fitzgerald

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2100383118. Published online 2021 Jun 24. doi: 10.1073/pnas.2100383118

PMCID:: PMC8255963

Abstract Article PDF–1.4M

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