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Select item 113030841.

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction

Ke Wang, Xing-Yang Liu, Sui-Feng Liu, Xiao-Xia Wang, Yi-Hua Wei, Jun-Rong Zhu, Jing Liu, Xiu Qin Xu, Lei Wen

Theranostics. 2024; 14(11): 4499–4518. Published online 2024 Aug 1. doi: 10.7150/thno.96045

PMCID:: PMC11303084

Abstract Article PDF–12M

Select item 109730622.

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse

Jin-Wen Kang, Jia-Peng He, Ying-Nan Liu, Yu Zhang, Shan-Shan Song, Qi-Xin Xu, Shu-Wen Wei, Lei Lu, Xiang-Qi Meng, Lin Xu, Bin Guo, Ren-Wei Su

Cell Mol Life Sci. 2024 Dec; 81(1): 155. Published online 2024 Mar 28. doi: 10.1007/s00018-024-05143-0

PMCID:: PMC10973062

Abstract Article PDF–23M

Select item 109570843.

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

Adam Myszczyszyn, Oliver Popp, Severine Kunz, Anje Sporbert, Simone Jung, Louis C. Penning, Annika Fendler, Philipp Mertins, Walter Birchmeier

PLoS One. 2024; 19(3): e0282938. Published online 2024 Mar 21. doi: 10.1371/journal.pone.0282938

PMCID:: PMC10957084

Abstract Article PDF–4.7M

Select item 109464404.

Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm

Matthew P. Pappas, Hiroko Kawakami, Dylan Corcoran, Katherine Q. Chen, Earl Parker Scott, Julia Wong, Micah D. Gearhart, Ryuichi Nishinakamura, Yasushi Nakagawa, Yasuhiko Kawakami

Development. 2024 Mar 1; 151(5): dev202649. Published online 2024 Mar 4. doi: 10.1242/dev.202649

PMCID:: PMC10946440

Abstract Article

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108820556.

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate

Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J. Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas

Nat Commun. 2024; 15: 1604. Published online 2024 Feb 21. doi: 10.1038/s41467-024-45716-y

PMCID:: PMC10882055

Abstract Article PDF–6.6M

Select item 108766487.

PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

Jong Geol Lee, Jung-Min Yon, Globinna Kim, Seul-Gi Lee, C-Yoon Kim, Seung-A Cheong, Hyun-Yi Kim, Jiyoung Yu, Kyunggon Kim, Young Hoon Sung, Hyun Ju Yoo, Dong-Cheol Woo, Jin Kyung Rho, Chang Hoon Ha, Chan-Gi Pack, Seak Hee Oh, Joon Seo Lim, Yu Mi Han, Eui-Ju Hong, Je Kyung Seong, Han-Woong Lee, Sang-Wook Lee, Ki-Up Lee, Chong Jai Kim, Sang-Yoon Nam, You Sook Cho, In-Jeoung Baek

Nat Commun. 2024; 15: 1487. Published online 2024 Feb 19. doi: 10.1038/s41467-024-45647-8

PMCID:: PMC10876648

Abstract Article PDF–10M

Select item 108664028.

Myeloid-specific knockout of Notch-1 inhibits MyD88- and TRIF-mediated TLR signaling pathways by regulating oxidative stress-SHP2 axis, thus restraining aneurysm progression

Yu Li, Ailin Guo, Jianlei Liu, Lijuan Tang, Lide Su, Zonghong Liu

Aging (Albany NY) 2024 Jan 31; 16(2): 1182–1191. Published online 2024 Jan 26. doi: 10.18632/aging.205392

PMCID:: PMC10866402

Abstract Article PDF–982K

Select item 108465399.

eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling

Lorraine Eley, Rachel V. Richardson, Ahlam Alqahtani, Bill Chaudhry, Deborah J. Henderson

Dis Model Mech. 2024 Jan 1; 17(1): dmm050265. Published online 2024 Jan 22. doi: 10.1242/dmm.050265

PMCID:: PMC10846539

Abstract Article

Select item 1078147510.

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

Mingming Zhang, Xiangyong Yue, Xueping Zhao, Yonggang Lu, Hongtao Liu, Zhe Zhang, Huan Ma, Xing Wang, Hanying Xing

Aging (Albany NY) 2023 Dec 31; 15(24): 15196–15212. Published online 2023 Dec 26. doi: 10.18632/aging.205342

PMCID:: PMC10781475

Abstract Article PDF–1.5M

Select item 1075608711.

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

Qian Gao, Yonggang Lu, Weiling Zhou

Aging (Albany NY) 2023 Dec 15; 15(23): 14323–14332. Published online 2023 Dec 13. doi: 10.18632/aging.205305

PMCID:: PMC10756087

Abstract Article PDF–1.0M

Select item 1069010912.

Netrin 1 directs vascular patterning and maturity in the developing kidney

Samuel E. Honeycutt, Pierre-Emmanuel Y. N'Guetta, Deanna M. Hardesty, Yubin Xiong, Shamus L. Cooper, Matthew J. Stevenson, Lori L. O'Brien

Development. 2023 Nov 15; 150(22): dev201886. Published online 2023 Nov 24. doi: 10.1242/dev.201886

PMCID:: PMC10690109

Abstract Article

Select item 1066513213.

Adherens junctions organize size-selective proteolytic hotspots critical for Notch signaling

Minsuk Kwak, Kaden M. Southard, Woon Ryoung Kim, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Hyun Jung Lee, Minji An, Seo Hyun Choi, Yunmin Jung, Kunwoo Noh, Justin Farlow, Anastasios Georgakopoulos, Nikolaos K. Robakis, Min K. Kang, Matthew L. Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev J. Gartner, Young-wook Jun

Nat Cell Biol. Author manuscript; available in PMC 2023 Nov 23.

Published in final edited form as: Nat Cell Biol. 2022 Dec; 24(12): 1739–1753. Published online 2022 Dec 1. doi: 10.1038/s41556-022-01031-6

PMCID:: PMC10665132

Abstract Article PDF–6.4M

Select item 1066297214.

Myocardial equation M1

-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation

Yidong Wang, Pengfei Lu, Bingruo Wu, Dario F. Riascos-Bernal, Nicholas E.S. Sibinga, Tomas Valenta, Konrad Basler, Bin Zhou

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Nov 21.

Published in final edited form as: J Mol Cell Cardiol. 2018 Oct; 123: 150–158. Published online 2018 Sep 8. doi: 10.1016/j.yjmcc.2018.09.001

PMCID:: PMC10662972

Abstract Article PDF–2.2M

Select item 1065671015.

Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis

Pengfei Lu, Bingruo Wu, Yidong Wang, Megan Russell, Yang Liu, Daniel J. Bernard, Deyou Zheng, Bin Zhou

Dev Cell. Author manuscript; available in PMC 2023 Nov 18.

Published in final edited form as: Dev Cell. 2023 May 8; 58(9): 791–805.e4. Published online 2023 Apr 5. doi: 10.1016/j.devcel.2023.03.009

PMCID:: PMC10656710

Abstract Article PDF–6.2M

Select item 1056008316.

Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis

Rachel K LoPilato, Heike Kroeger, Sneha K Mohan, James D Lauderdale, Neil Grimsey, Robert S Haltiwanger

Glycobiology. 2023 Aug; 33(8): 661–672. Published online 2023 Jun 17. doi: 10.1093/glycob/cwad048

PMCID:: PMC10560083

Abstract Article PDF–1.5M

Select item 1054730017.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Abstract Article PDF–41M

Select item 1048047718.

Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5

Norika Liu, Naofumi Kawahira, Yasuhiro Nakashima, Haruko Nakano, Akiyasu Iwase, Yasunobu Uchijima, Mei Wang, Sean M. Wu, Susumu Minamisawa, Hiroki Kurihara, Atsushi Nakano

Nat Commun. 2023; 14: 5398. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41039-6

PMCID:: PMC10480477

Abstract Article PDF–2.4M

Select item 1041071719.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 1035903520.

Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti

Helen R. Maunsell, Kathryn Ellis, Matthew W. Kelley, Elizabeth Carroll Driver

J Neurosci. 2023 Jul 19; 43(29): 5305–5318. doi: 10.1523/JNEUROSCI.2141-22.2023

PMCID:: PMC10359035

Abstract Article PDF–7.2M

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