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Items: 1 to 20 of 61

1.
Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression
Jean Lee, Leonid A. Yurkovetskiy, Derek Reiman, Lara Frommer, Zoe Strong, Anthony Chang, George J. Kahaly, Aly A. Khan, Alexander V. Chervonsky
Nat Commun. 2024; 15: 7688. Published online 2024 Sep 3. doi: 10.1038/s41467-024-51869-7
PMCID:
PMC11372096
AbstractArticlePDF–2.5M
2.
Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity
Robin C. Orozco, Kristi Marquardt, Isaraphorn Pratumchai, Anam Fatima Shaikh, Kerri Mowen, Alain Domissy, John R. Teijaro, Linda A. Sherman
PLoS Pathog. 2024 Mar; 20(3): e1012095. Published online 2024 Mar 21. doi: 10.1371/journal.ppat.1012095
PMCID:
PMC10987006
AbstractArticlePDF–3.7M
3.
Structural basis for a novel, highly specific interaction involving the Csk SH3 domain and its natural ligand
Ranajeet Ghose, Alexander Shekhtman, Michael J. Goger, Hong Ji, David Cowburn
Nat Struct Biol. Author manuscript; available in PMC 2024 Feb 13.
Published in final edited form as: Nat Struct Biol. 2001 Nov; 8(11): 998–1004. doi: 10.1038/nsb1101-998
PMCID:
PMC10862353
AbstractArticlePDF–685K
4.
Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice
Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng
BMC Med. 2023; 21: 252. Published online 2023 Jul 13. doi: 10.1186/s12916-023-02888-6
PMCID:
PMC10347738
AbstractArticlePDF–14M
5.
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
Jaime James, Yifei Chen, Clara M Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika Åstrand, Rajneesh Malhotra, Bernard Malissen, Roman A Zubarev, Elias SJ Arnér, Rikard Holmdahl
eLife. 2022; 11: e74549. Published online 2022 May 19. doi: 10.7554/eLife.74549
PMCID:
PMC9119677
AbstractArticlePDF–2.2M
6.
Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors
Xin Du, Phillip K. Darcy, Florian Wiede, Tony Tiganis
Mol Cell Biol. 2022 Mar; 42(3): e00449-21. Prepublished online 2022 Jan 18. Published online 2022 Mar 17. doi: 10.1128/mcb.00449-21
PMCID:
PMC8929386
AbstractArticlePDF–3.0M
7.
Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization
Yunwei Zhang, Xiaofei Zhang, Hongji Zhang, Peng Song, Wenming Pan, Peng Xu, Guoliang Wang, Ping Hu, Zixuan Wang, Kunpeng Huang, Xiaodong Zhang, Hui Wang, Jinxiang Zhang
Front Immunol. 2021; 12: 811164. Published online 2022 Jan 12. doi: 10.3389/fimmu.2021.811164
PMCID:
PMC8790700
AbstractArticlePDF–15M
8.
Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity
Robin C. Orozco, Kristi Marquardt, Kerri Mowen, Linda A. Sherman
J Immunol. 2021 Sep 15; 207(6): 1662–1671. Published online 2021 Sep 15. doi: 10.4049/jimmunol.2100304
PMCID:
PMC8428750
AbstractArticlePDF–2.7M
9.
Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope
Front Immunol. 2020; 11: 376. Published online 2020 Mar 4. doi: 10.3389/fimmu.2020.00376
PMCID:
PMC7065600
AbstractArticlePDF–1.0M
10.
PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion
Johanna A. Knipper, David Wright, Andrew P. Cope, Bernard Malissen, Rose Zamoyska
Front Immunol. 2020; 11: 52. Published online 2020 Jan 28. doi: 10.3389/fimmu.2020.00052
PMCID:
PMC6997546
AbstractArticlePDF–3.6M
11.
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.
Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8
PMCID:
PMC6859066
AbstractArticlePDF–2.9M
12.
The autoimmune risk variant PTPN22 C1858T alters B cell tolerance at discrete checkpoints and differentially shapes the naïve repertoire
Genita Metzler, Xuezhi Dai, Christopher D. Thouvenel, Socheath Khim, Tania Habib, Jane H. Buckner, David J. Rawlings
J Immunol. Author manuscript; available in PMC 2019 Oct 14.
Published in final edited form as: J Immunol. 2017 Oct 1; 199(7): 2249–2260. Published online 2017 Aug 11. doi: 10.4049/jimmunol.1700601
PMCID:
PMC6791366
AbstractArticlePDF–1.5M
13.
Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors
Rebecca J. Brownlie, David Wright, Rose Zamoyska, Robert J. Salmond
JCI Insight. 2019 Aug 22; 4(16): e127847. Published online 2019 Aug 22. doi: 10.1172/jci.insight.127847
PMCID:
PMC6777814
AbstractArticlePDF–1.4M
14.
Experimental colitis in IL‐10‐deficient mice ameliorates in the absence of PTPN22
T. Jofra, G. Galvani, I. Cosorich, L. De Giorgi, A. Annoni, A. Vecchione, C. Sorini, M. Falcone, G. Fousteri
Clin Exp Immunol. 2019 Sep; 197(3): 263–275. Published online 2019 Jul 10. doi: 10.1111/cei.13339
PMCID:
PMC6693971
AbstractArticlePDF–600K
15.
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner
Marianne R. Spalinger, Thomas S.B. Schmidt, Marlene Schwarzfischer, Larissa Hering, Kirstin Atrott, Silvia Lang, Claudia Gottier, Annelies Geirnaert, Christophe Lacroix, Xuezhi Dai, David J. Rawlings, Andrew C. Chan, Christian von Mering, Gerhard Rogler, Michael Scharl
J Clin Invest. 2019 Jun 3; 129(6): 2527–2541. Published online 2019 May 20. doi: 10.1172/JCI123263
PMCID:
PMC6546451
AbstractArticlePDF–13M
16.
Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses
Cristina Sanchez-Blanco, Fiona Clarke, Georgina H. Cornish, David Depoil, Stephen J. Thompson, Xuezhi Dai, David J. Rawlings, Michael L. Dustin, Rose Zamoyska, Andrew P. Cope, Harriet A. Purvis
J Autoimmun. 2018 Nov; 94: 45–55. doi: 10.1016/j.jaut.2018.07.008
PMCID:
PMC6198113
AbstractArticlePDF–1.7M
17.
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
Fiona Clarke, Harriet A. Purvis, Cristina Sanchez-Blanco, Enrique Gutiérrez-Martinez, Georgina H. Cornish, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope
Sci Rep. 2018; 8: 12692. Published online 2018 Aug 23. doi: 10.1038/s41598-018-31179-x
PMCID:
PMC6107551
AbstractArticlePDF–1.9M
18.
Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice
Harriet A Purvis, Fiona Clarke, Christine K Jordan, Cristina Sanchez Blanco, Georgina H Cornish, Xuezhi Dai, David J Rawlings, Rose Zamoyska, Andrew P Cope
Eur J Immunol. 2018 Feb; 48(2): 306–315. Published online 2017 Oct 20. doi: 10.1002/eji.201747092
PMCID:
PMC5859948
AbstractArticlePDF–1.8M
19.
Lack of PTPN22 increases LFA-1-dependent adhesion of Murine Regulatory T Cells improving their regulatory Function
Rebecca J Brownlie, Lisa A Miosge, Demetrios Vassilakos, Lena M Svensson, Andrew Cope, Rose Zamoyska
Sci Signal. Author manuscript; available in PMC 2018 Mar 5.
Published in final edited form as: Sci Signal. 2012 Nov 27; 5(252): ra87. Published online 2012 Nov 27. doi: 10.1126/scisignal.2003365
PMCID:
PMC5836999
AbstractArticlePDF–2.5M
20.
The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity
Jacquelyn A. Gorman, Christian Hundhausen, John S. Errett, Amy E. Stone, Eric J. Allenspach, Yan Ge, Tanvi Arkatkar, Courtnee Clough, Xuezhi Dai, Socheath Khim, Kathleen Pestal, Denny Liggitt, Karen Cerosaletti, Daniel B. Stetson, Richard G. James, Mohamed Oukka, Patrick Concannon, Michael Gale, Jr., Jane H. Buckner, David J. Rawlings
Nat Immunol. Author manuscript; available in PMC 2017 Nov 29.
Published in final edited form as: Nat Immunol. 2017 Jul; 18(7): 744–752. Published online 2017 May 29. doi: 10.1038/ni.3766
PMCID:
PMC5697900
AbstractArticlePDF–1.0M

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