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Items: 1 to 20 of 137

1.
Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases
Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld
Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2
PMCID:
PMC11108519
AbstractArticlePDF–1.2M
2.
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions
Saori Yoshimura, Ryuki Shimada, Koji Kikuchi, Soichiro Kawagoe, Hironori Abe, Sakie Iisaka, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Naoki Tani, Takashi Ohba, Eiji Kondoh, Tomohide Saio, Kimi Araki, Kei-ichiro Ishiguro
Nat Commun. 2024; 15: 3330. Published online 2024 Apr 29. doi: 10.1038/s41467-024-47601-0
PMCID:
PMC11059408
AbstractArticlePDF–8.4M
3.
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6
PMCID:
PMC10940294
AbstractArticlePDF–6.0M
4.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
5.
SPIDR is required for homologous recombination during mammalian meiosis
Tao Huang, Xinyue Wu, Shiyu Wang, Ziyou Bao, Yanling Wan, Ziqi Wang, Mengjing Li, Xiaochen Yu, Yue Lv, Zhaojian Liu, Xiangfeng Chen, Wai-Yee Chan, Fei Gao, Gang Lu, Zi-Jiang Chen, Hongbin Liu
Nucleic Acids Res. 2023 May 8; 51(8): 3855–3868. Published online 2023 Mar 20. doi: 10.1093/nar/gkad154
PMCID:
PMC10164582
AbstractArticlePDF–11M
6.
Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity
Shuwen He, John P. Gillies, Juliana L. Zang, Carmen M. Córdoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E. DeSantis, Hiroki Shibuya
Nat Commun. 2023; 14: 1715. Published online 2023 Mar 27. doi: 10.1038/s41467-023-37370-7
PMCID:
PMC10042829
AbstractArticlePDF–4.3M
7.
DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development
Simin Zhao, Chengzi Huang, Yajuan Yang, Weiwei Xu, Yongze Yu, Canxin Wen, Lili Cao, Fei Gao, Yingying Qin, Zi-Jiang Chen, Ting Guo, Shidou Zhao
J Biol Chem. 2023 Mar; 299(3): 102905. Published online 2023 Jan 13. doi: 10.1016/j.jbc.2023.102905
PMCID:
PMC9971320
AbstractArticlePDF–4.2M
8.
M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination
Yang Li, Yufan Wu, Ihsan Khan, Jianteng Zhou, Yue Lu, Jingwei Ye, Junyan Liu, Xuefeng Xie, Congyuan Hu, Hanwei Jiang, Suixing Fan, Huan Zhang, Yuanwei Zhang, Xiaohua Jiang, Bo Xu, Hui Ma, Qinghua Shi
EMBO Rep. 2023 Feb; 24(2): e55778. Published online 2022 Nov 28. doi: 10.15252/embr.202255778
PMCID:
PMC9900333
AbstractArticlePDF–14M
9.
Resolution of sequence divergence for repeat-mediated deletions shows a polarity that is mediated by MLH1
Hannah Trost, Arianna Merkell, Felicia Wednesday Lopezcolorado, Jeremy M Stark
Nucleic Acids Res. 2023 Jan 25; 51(2): 650–667. Published online 2023 Jan 9. doi: 10.1093/nar/gkac1240
PMCID:
PMC9881173
AbstractArticlePDF–6.3M
10.
MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice
Samina Kazi, Julio M. Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez‐Solis, Kaori Nozawa, Zhifeng Yu, Martin M. Matzuk, Renata Prunskaite‐Hyyryläinen
FASEB J. 2022 Sep; 36(9): e22479. Published online 2022 Aug 3. doi: 10.1096/fj.202101168RR
PMCID:
PMC9544956
AbstractArticlePDF–9.8M
11.
Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice
Seiya Oura, Toshiaki Hino, Takashi Satoh, Taichi Noda, Takayuki Koyano, Ayako Isotani, Makoto Matsuyama, Shizuo Akira, Kei-ichiro Ishiguro, Masahito Ikawa
PLoS Genet. 2022 Jun; 18(6): e1010241. Published online 2022 Jun 1. doi: 10.1371/journal.pgen.1010241
PMCID:
PMC9191731
AbstractArticlePDF–4.1M
12.
FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
Nobuhiro Tanno, Kazumasa Takemoto, Yuki Takada-Horisawa, Ryuki Shimada, Sayoko Fujimura, Naoki Tani, Naoki Takeda, Kimi Araki, Kei-ichiro Ishiguro
iScience. 2022 Apr 15; 25(4): 104008. Published online 2022 Mar 1. doi: 10.1016/j.isci.2022.104008
PMCID:
PMC8931362
AbstractArticlePDF–9.0M
13.
SIRT7 promotes chromosome synapsis during prophase I of female meiosis
Berta N. Vazquez, Cecilia S. Blengini, Yurdiana Hernandez, Lourdes Serrano, Karen Schindler
Chromosoma. Author manuscript; available in PMC 2021 Oct 6.
Published in final edited form as: Chromosoma. 2019 Sep; 128(3): 369–383. Published online 2019 Jun 29. doi: 10.1007/s00412-019-00713-9
PMCID:
PMC8494110
AbstractArticlePDF–2.5M
14.
Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis
Roberto de la Fuente, Florencia Pratto, Abrahan Hernández-Hernández, Marcia Manterola, Pablo López-Jiménez, Rocío Gómez, Alberto Viera, María Teresa Parra, Anna Kouznetsova, R. Daniel Camerini-Otero, Jesús Page
Cells. 2021 Sep; 10(9): 2311. Published online 2021 Sep 3. doi: 10.3390/cells10092311
PMCID:
PMC8467405
AbstractArticlePDF–12M
15.
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease
Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L. Bunting, Sarah G. Aldous, Antonio Porro, José R. Vicente, Nicholas D. Allen, Hilary Wilkinson, Gillian P. Bates, Alessandro A. Sartori, Konstantinos Thalassinos, Gabriel Balmus, Sarah J. Tabrizi
Cell Rep. 2021 Aug 31; 36(9): 109649. Published online 2021 Aug 31. doi: 10.1016/j.celrep.2021.109649
PMCID:
PMC8424649
AbstractArticlePDF–2.9M
16.
Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging
Priti Singh, Robert Fragoza, Cecilia S. Blengini, Tina N. Tran, Gianno Pannafino, Najla Al-Sweel, Kerry J. Schimenti, Karen Schindler, Eric A. Alani, Haiyuan Yu, John C. Schimenti
Nat Commun. 2021; 12: 5005. Published online 2021 Aug 18. doi: 10.1038/s41467-021-25028-1
PMCID:
PMC8373927
AbstractArticlePDF–3.2M
17.
Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm
Kul S Shrestha, Minna M Tuominen, Liisa Kauppi
Mutagenesis. 2021 May; 36(3): 237–244. Published online 2021 Mar 19. doi: 10.1093/mutage/geab010
PMCID:
PMC8262379
AbstractArticlePDF–842K
18.
Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade
Melissa A. Galati, Karl P. Hodel, Miki S. Gams, Sumedha Sudhaman, Taylor Bridge, Walter J. Zahurancik, Nathan A. Ungerleider, Vivian S. Park, Ayse B. Ercan, Lazar Joksimovic, Iram Siddiqui, Robert Siddaway, Melissa Edwards, Richard de Borja, Dana Elshaer, Jiil Chung, Victoria J. Forster, Nuno M. Nunes, Melyssa Aronson, Xia Wang, Jagadeesh Ramdas, Andrea Seeley, Tomasz Sarosiek, Gavin P. Dunn, Jonathan N. Byrd, Oz Mordechai, Carol Durno, Alberto Martin, Adam Shlien, Eric Bouffet, Zucai Suo, James G. Jackson, Cynthia E. Hawkins, Cynthia J. Guidos, Zachary F. Pursell, Uri Tabori
Cancer Res. Author manuscript; available in PMC 2021 Jun 22.
Published in final edited form as: Cancer Res. 2020 Dec 15; 80(24): 5606–5618. Published online 2020 Sep 16. doi: 10.1158/0008-5472.CAN-20-0624
PMCID:
PMC8218238
AbstractArticlePDF–1.6M
19.
Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors
Inken Salewski, Julia Henne, Leonie Engster, Bjoern Schneider, Heiko Lemcke, Anna Skorska, Peggy Berlin, Larissa Henze, Christian Junghanss, Claudia Maletzki
Int J Mol Sci. 2021 Jun; 22(11): 5990. Published online 2021 Jun 1. doi: 10.3390/ijms22115990
PMCID:
PMC8199186
AbstractArticlePDF–3.7M
20.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Nat Commun. 2021; 12: 3464. Published online 2021 Jun 8. doi: 10.1038/s41467-021-23717-5
PMCID:
PMC8187652
AbstractArticlePDF–3.3M

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