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Select item 109535651.

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai

Adv Sci (Weinh) 2024 Mar; 11(11): 2305992. Published online 2024 Jan 9. doi: 10.1002/advs.202305992

PMCID:: PMC10953565

Abstract Article PDF–5.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104042863.

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Cornelis J. Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B. Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots, Eva van Rooij

Nat Commun. 2023; 14: 4716. Published online 2023 Aug 5. doi: 10.1038/s41467-023-40203-2

PMCID:: PMC10404286

Abstract Article PDF–3.4M

Select item 103904924.

Three-dimensional molecular architecture of mouse organogenesis

Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng

Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7

PMCID:: PMC10390492

Abstract Article PDF–13M

Select item 97007815.

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang

Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y

PMCID:: PMC9700781

Abstract Article PDF–11M

Select item 96361506.

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, Heike Serke, Olga Lityagina, Felix A. Trogisch, Mona Malek Mohammadi, Ibrahim El-Battrawy, Johannes Backs, Thomas Wieland, Joerg Heineke, Gergana Dobreva

Nat Commun. 2022; 13: 6663. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34366-7

PMCID:: PMC9636150

Abstract Article PDF–8.9M

Select item 91948677.

Brain-derived neurotrophic factor regulates LYN kinase–mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons

Xiaobing Li, Rong-Rong Yuan, Qixia Wang, Shouyu Chai, Zhengying Zhang, Yue Wang, Shu-Hong Huang

J Biol Chem. 2022 Jun; 298(6): 102054. Published online 2022 May 20. doi: 10.1016/j.jbc.2022.102054

PMCID:: PMC9194867

Abstract Article PDF–1.8M

Select item 90749888.

Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca²⁺ cycling

Senka Ljubojević-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Julia Schipke, Marlene Schmidt, Katharina-Maria Kling, Greta Therese Franke, Viktoria Herbst, Andreas Zirlik, Dirk von Lewinski, Daniel Scherr, Peter P Rainer, Michael Kohlhaas, Alexander Nickel, Christian Mühlfeld, Christoph Maack, Simon Sedej

Cardiovasc Res. 2022 May; 118(6): 1492–1505. Published online 2021 Mar 22. doi: 10.1093/cvr/cvab112

PMCID:: PMC9074988

Abstract Article PDF–1.8M

Select item 88081819.

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

Wesley T. Hodges, Chaowapong Jarasvaraparn, Daniel Ferguson, Kristine Griffett, Lauren E. Gill, Yana Chen, Ma. Xenia G. Ilagan, Lamees Hegazy, Bahaa Elgendy, Kevin Cho, Gary J. Patti, Kyle S. McCommis, Brian N. Finck

J Biol Chem. 2022 Feb; 298(2): 101554. Published online 2021 Dec 30. doi: 10.1016/j.jbc.2021.101554

PMCID:: PMC8808181

Abstract Article PDF–2.5M

Select item 866816310.

Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca²⁺ sensitivity

Jiajia Zhang, Li Wang, Katarzyna Kazmierczak, Hang Yun, Danuta Szczesna-Cordary, Masataka Kawai

FEBS J. Author manuscript; available in PMC 2021 Dec 13.

Published in final edited form as: FEBS J. 2021 Aug; 288(15): 4596–4613. Published online 2021 Mar 10. doi: 10.1111/febs.15753

PMCID:: PMC8668163

Abstract Article PDF–1.1M

Select item 827562711.

Cell type-specific roles of PAR1 in Coxsackievirus B3 infection

Michael F. Bode, Clare M. Schmedes, Grant J. Egnatz, Vanthana Bharathi, Yohei M. Hisada, David Martinez, Tomohiro Kawano, Alice Weithauser, Leah Rosenfeldt, Ursula Rauch, Joseph S. Palumbo, Silvio Antoniak, Nigel Mackman

Sci Rep. 2021; 11: 14264. Published online 2021 Jul 12. doi: 10.1038/s41598-021-93759-8

PMCID:: PMC8275627

Abstract Article PDF–1.6M

Select item 826231912.

Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations

Kari T. Chambers, Michael A. Cooper, Alison R. Swearingen, Rita T. Brookheart, George G. Schweitzer, Carla J. Weinheimer, Attila Kovacs, Timothy R. Koves, Deborah M. Muoio, Kyle S. McCommis, Brian N. Finck

JCI Insight. 2021 May 10; 6(9): e134340. Published online 2021 May 10. doi: 10.1172/jci.insight.134340

PMCID:: PMC8262319

Abstract Article PDF–2.8M

Select item 823323113.

Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury

Yuening Liu, Jingrui Chen, Peng Xia, Constantine A. Stratakis, Zhaokang Cheng

J Biol Chem. 2021 Jul; 297(1): 100850. Published online 2021 Jun 1. doi: 10.1016/j.jbc.2021.100850

PMCID:: PMC8233231

Abstract Article PDF–3.5M

Select item 815969114.

Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Yan Liang, Robert C. Lyon, Jason Pellman, William H. Bradford, Stephan Lange, Julius Bogomolovas, Nancy D. Dalton, Yusu Gu, Marcus Bobar, Mong-Hong Lee, Tomoo Iwakuma, Vishal Nigam, Angeliki Asimaki, Melvin Scheinman, Kirk L. Peterson, Farah Sheikh

J Clin Invest. 2021 Jun 1; 131(11): e137689. Published online 2021 Jun 1. doi: 10.1172/JCI137689

PMCID:: PMC8159691

Abstract Article PDF–13M

Select item 809710115.

Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation

Yifeng Wang, Tao Jiang, Jiani Xu, Yayun Gu, Yan Zhou, Yuan Lin, Yifei Wu, Wei Li, Cheng Wang, Bin Shen, Xuming Mo, Xiaowei Wang, Bin Zhou, Chenyue Ding, Zhibin Hu

Front Cell Dev Biol. 2021; 9: 623394. Published online 2021 Apr 21. doi: 10.3389/fcell.2021.623394

PMCID:: PMC8097101

Abstract Article PDF–802K

Select item 807716816.

Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin

David V. Rasicci, Orville Kirkland, Jr., Faruk H. Moonschi, Neil B. Wood, Danuta Szczesna-Cordary, Michael J. Previs, Jonathan F. Wenk, Kenneth S. Campbell, Christopher M. Yengo

J Gen Physiol. 2021 Jul 5; 153(7): e202012811. Published online 2021 Apr 23. doi: 10.1085/jgp.202012811

PMCID:: PMC8077168

Abstract Article PDF–3.2M

Select item 795796017.

Nutritional Modulation of Heart Failure in Mitochondrial Pyruvate Carrier-Deficient Mice

Kyle S. McCommis, Attila Kovacs, Carla J. Weinheimer, Trevor M. Shew, Timothy R. Koves, Olga R. Ilkayeva, Dakota R. Kamm, Kelly D. Pyles, M. Todd King, Richard L. Veech, Brian J. DeBosch, Deborah M. Muoio, Richard W. Gross, Brian N. Finck

Nat Metab. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Nat Metab. 2020 Nov; 2(11): 1232–1247. Published online 2020 Oct 26. doi: 10.1038/s42255-020-00296-1

PMCID:: PMC7957960

Abstract Article PDF–5.9M

Select item 781612418.

Trophectoderm mechanics direct epiblast shape upon embryo implantation

Antonia Weberling, Magdalena Zernicka-Goetz

Cell Rep. 2021 Jan 19; 34(3): 108655. Published online 2021 Jan 19. doi: 10.1016/j.celrep.2020.108655

PMCID:: PMC7816124

Abstract Article

Select item 778258919.

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

Xinyun Chen, Ying Liu, Chen Xu, Lina Ba, Zhuo Liu, Xiuya Li, Jie Huang, Ed Simpson, Hongyu Gao, Dayan Cao, Wei Sheng, Hanping Qi, Hongrui Ji, Maria Sanderson, Chen-Leng Cai, Xiaohui Li, Lei Yang, Jie Na, Kenichi Yamamura, Yunlong Liu, Guoying Huang, Weinian Shou, Ning Sun

Nat Commun. 2021; 12: 89. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20327-5

PMCID:: PMC7782589

Abstract Article PDF–8.6M

Select item 774970820.

Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye

Wesley R Sun, Sara Ramirez, Kelly E Spiller, Yan Zhao, Sabine Fuhrmann

Hum Mol Genet. 2020 Oct 15; 29(20): 3373–3387. Published online 2020 Oct 19. doi: 10.1093/hmg/ddaa228

PMCID:: PMC7749708

Abstract Article PDF–2.1M

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