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Select item 112591781.

Beta2 adrenergic receptor–mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury

Rui Jiang, Zhichao Lu, Chenxing Wang, Jun Xiao, Qianqian Liu, Xide Xu, Jinlong Shi, Jianhong Shen, Xingjia Zhu, Peipei Gong, Qian-Xing Zhuang, Kaibin Shi, Wei Shi

Sci Adv. 2024 Jul 19; 10(29): eadp5239. Published online 2024 Jul 19. doi: 10.1126/sciadv.adp5239

PMCID:: PMC11259178

Abstract Article PDF–8.6M

Select item 109817072.

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Nat Commun. 2024; 15: 2803. Published online 2024 Mar 30. doi: 10.1038/s41467-024-47096-9

PMCID:: PMC10981707

Abstract Article PDF–3.0M

Select item 109390713.

Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway

Yanjie Lu, Die Cheng, Jiayu Pang, Yuqiao Peng, Shunkang Jin, Xinyu Zhang, Yuhong Li, Yanzhen Zuo

Cell Stress Chaperones. 2024 Feb; 29(1): 201–215. Published online 2024 Feb 6. doi: 10.1016/j.cstres.2024.02.001

PMCID:: PMC10939071

Abstract Article PDF–12M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108092235.

Epinephrine inhibits PI3Kα via the Hippo kinases

Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves

Cell Rep. Author manuscript; available in PMC 2024 Jan 25.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113535. Published online 2023 Dec 4. doi: 10.1016/j.celrep.2023.113535

PMCID:: PMC10809223

Abstract Article PDF–2.3M

Select item 106972136.

Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms

Arjun Muralidharan, Alexander Samoshkin, Marino Convertino, Marjo Hannele Piltonen, Pavel Gris, Jian Wang, Changyu Jiang, Richard Klares, III, Alexander Linton, Ru-Rong Ji, William Maixner, Nikolay V. Dokholyan, Jeffrey S. Mogil, Luda Diatchenko

Br J Pharmacol. Author manuscript; available in PMC 2023 Dec 5.

Published in final edited form as: Br J Pharmacol. 2021 Jul; 178(13): 2709–2726. Published online 2021 Apr 30. doi: 10.1111/bph.15463

PMCID:: PMC10697213

Abstract Article PDF–2.1M

Select item 104917307.

VMHdm/c^SF-1 neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive

Takuya Yoshida, Mina Fujitani, Scotlynn Farmer, Ami Harada, Zhen Shi, Jenny J. Lee, Arely Tinajero, Ashish K. Singha, Teppei Fujikawa

Mol Metab. 2023 Nov; 77: 101792. Published online 2023 Aug 24. doi: 10.1016/j.molmet.2023.101792

PMCID:: PMC10491730

Abstract Article PDF–2.6M

Select item 104812968.

Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration

Hao-Kun Xu, Jie-Xi Liu, Chen-Xi Zheng, Lu Liu, Chao Ma, Jiong-Yi Tian, Yuan Yuan, Yuan Cao, Shu-Juan Xing, Si-Ying Liu, Qiang Li, Ya-Juan Zhao, Liang Kong, Yong-Jin Chen, Bing-Dong Sui

iScience. 2023 Sep 15; 26(9): 107455. Published online 2023 Jul 22. doi: 10.1016/j.isci.2023.107455

PMCID:: PMC10481296

Abstract Article PDF–7.8M

Select item 103227169.

GDF15 promotes weight loss by enhancing energy expenditure in muscle

Dongdong Wang, Logan K. Townsend, Geneviève J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A. Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A. Pileggi, Sonia Rehal, Eric M. Desjardins, Evangelia E. Tsakiridis, James S. V. Lally, Emma Sara Juracic, A. Russell Tupling, Hertzel C. Gerstein, Guillaume Paré, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J. Hawke, John R. Speakman, Denis P. Blondin, Graham P. Holloway, Sebastian Beck Jørgensen, Gregory R. Steinberg

Nature. 2023; 619(7968): 143–150. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06249-4

PMCID:: PMC10322716

Abstract Article PDF–26M

Select item 1024181910.

Neutrophil-derived catecholamines mediate negative stress effects on bone

Miriam E. A. Tschaffon-Müller, Elena Kempter, Lena Steppe, Sandra Kupfer, Melanie R. Kuhn, Florian Gebhard, Carlos Pankratz, Miriam Kalbitz, Konrad Schütze, Harald Gündel, Nele Kaleck, Gudrun Strauß, Jean Vacher, Hiroshi Ichinose, Katja Weimer, Anita Ignatius, Melanie Haffner-Luntzer, Stefan O. Reber

Nat Commun. 2023; 14: 3262. Published online 2023 Jun 5. doi: 10.1038/s41467-023-38616-0

PMCID:: PMC10241819

Abstract Article PDF–3.1M

Select item 1015803011.

Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway

Yunfeng Guan, Wang Yao, Hao Yu, Ying Feng, Yiyang Zhao, Xiangyang Zhan, Yan Wang

Int J Biol Sci. 2023; 19(7): 2006–2019. Published online 2023 Apr 2. doi: 10.7150/ijbs.79583

PMCID:: PMC10158030

Abstract Article PDF–5.8M

Select item 997575512.

Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense

Gabriel Komla Adzika, Richard Mprah, Ruqayya Rizvi, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Prosperl Ivette Wowui, Seyram Yao Adzraku, Joseph Adu-Amankwaah, Fengli Wang, Yuwen Lin, Lu Fu, Xiaomei Liu, Jie Xiang, Hong Sun

Front Immunol. 2023; 14: 1124649. Published online 2023 Feb 15. doi: 10.3389/fimmu.2023.1124649

PMCID:: PMC9975755

Abstract Article PDF–32M

Select item 989823713.

Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease

Hee-Hoon Kim, Young-Ri Shim, Sung Eun Choi, Myung-Ho Kim, Giljae Lee, Hyun Ju You, Won-Mook Choi, Keungmo Yang, Tom Ryu, Kyurae Kim, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyuk Soo Eun, Seok-Hwan Kim, GwangPyo Ko, Jong-Eun Park, Bin Gao, Won Kim, Won-Il Jeong

Exp Mol Med. 2023 Jan; 55(1): 158–170. Published online 2023 Jan 11. doi: 10.1038/s12276-022-00921-x

PMCID:: PMC9898237

Abstract Article PDF–8.9M

Select item 985637314.

Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice

Elisa Damo, Amit Agarwal, Manuela Simonetti

Cells. 2023 Jan; 12(2): 284. Published online 2023 Jan 11. doi: 10.3390/cells12020284

PMCID:: PMC9856373

Abstract Article PDF–9.2M

Select item 979888515.

Brain motor and fear circuits regulate leukocytes during acute stress

Wolfram C. Poller, Jeffrey Downey, Agnes A. Mooslechner, Nargis Khan, Long Li, Christopher T. Chan, Cameron S. McAlpine, Chunliang Xu, Florian Kahles, Shun He, Henrike Janssen, John E. Mindur, Sumnima Singh, Máté G. Kiss, Laura Alonso-Herranz, Yoshiko Iwamoto, Rainer H. Kohler, Lai Ping Wong, Kashish Chetal, Scott J. Russo, Ruslan I. Sadreyev, Ralph Weissleder, Matthias Nahrendorf, Paul S. Frenette, Maziar Divangahi, Filip K. Swirski

Nature. Author manuscript; available in PMC 2022 Dec 29.

Published in final edited form as: Nature. 2022 Jul; 607(7919): 578–584. Published online 2022 May 30. doi: 10.1038/s41586-022-04890-z

PMCID:: PMC9798885

Abstract Article PDF–4.5M

Select item 973409816.

Noradrenergic signaling mediates cortical early tagging and storage of remote memory

Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu

Nat Commun. 2022; 13: 7623. Published online 2022 Dec 9. doi: 10.1038/s41467-022-35342-x

PMCID:: PMC9734098

Abstract Article PDF–6.2M

Select item 939132217.

S-nitrosylation is required for β₂AR desensitization and experimental asthma

Fabio V. Fonseca, Thomas M. Raffay, Kunhong Xiao, Precious J. McLaughlin, Zhaoxia Qian, Zachary W. Grimmett, Naoko Adachi, Benlian Wang, Alfred Hausladen, Brian A. Cobb, Rongli Zhang, Douglas T. Hess, Benjamin Gaston, Nevin A. Lambert, James D. Reynolds, Richard T. Premont, Jonathan S. Stamler

Mol Cell. Author manuscript; available in PMC 2023 Aug 18.

Published in final edited form as: Mol Cell. 2022 Aug 18; 82(16): 3089–3102.e7. Published online 2022 Aug 4. doi: 10.1016/j.molcel.2022.06.033

PMCID:: PMC9391322

Abstract Article PDF–3.3M

Select item 936291518.

Adrenergic signaling controls early transcriptional programs during CD8⁺ T cell responses to viral infection

Leonardo D. Estrada, Didem Ağaç Çobanoğlu, Aaron Wise, Robert W. Maples, Murat Can Çobanoğlu, J. David Farrar

PLoS One. 2022; 17(8): e0272017. Published online 2022 Aug 9. doi: 10.1371/journal.pone.0272017

PMCID:: PMC9362915

Abstract Article PDF–2.1M

Select item 930850519.

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange

Kuan Zhang, Erica Yao, Shao-An Wang, Ethan Chuang, Julia Wong, Liliana Minichiello, Andrew Schroeder, Walter Eckalbar, Paul J. Wolters, Pao-Tien Chuang

Dev Cell. Author manuscript; available in PMC 2023 Jul 11.

Published in final edited form as: Dev Cell. 2022 Jul 11; 57(13): 1566–1581.e7. Published online 2022 Jun 16. doi: 10.1016/j.devcel.2022.05.021

PMCID:: PMC9308505

Abstract Article PDF–5.9M

Select item 920252320.

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang

Cell Rep. Author manuscript; available in PMC 2022 Jun 16.

Published in final edited form as: Cell Rep. 2021 Sep 21; 36(12): 109742. doi: 10.1016/j.celrep.2021.109742

PMCID:: PMC9202523

Abstract Article PDF–4.2M

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