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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107809472.

Discovery and validation of genes driving drug‐intake and related behavioral traits in mice

Tyler A. Roy, Jason A. Bubier, Price E. Dickson, Troy D. Wilcox, Juliet Ndukum, James W. Clark, Stacey J. Sukoff Rizzo, John C. Crabbe, James M. Denegre, Karen L. Svenson, Robert E. Braun, Vivek Kumar, Stephen A. Murray, Jacqueline K. White, Vivek M. Philip, Elissa J. Chesler

Genes Brain Behav. 2024 Feb; 23(1): e12875. Published online 2024 Jan 2. doi: 10.1111/gbb.12875

PMCID:: PMC10780947

Abstract Article PDF–2.6M

Select item 104087083.

Complement factor B is essential for the proper function of the peripheral auditory system

LaShardai N. Brown, Jeremy L. Barth, Shabih Jafri, Jeffrey A. Rumschlag, Tyreek R. Jenkins, Carl Atkinson, Hainan Lang

Front Neurol. 2023; 14: 1214408. Published online 2023 Jul 25. doi: 10.3389/fneur.2023.1214408

PMCID:: PMC10408708

Abstract Article PDF–3.9M

Select item 102901024.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation

Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real

Nat Commun. 2023; 14: 3761. Published online 2023 Jun 23. doi: 10.1038/s41467-023-39291-x

PMCID:: PMC10290102

Abstract Article PDF–3.4M

Select item 98699765.

Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease

Zi-jun Sun, Dong-yuan Chang, Min Chen, Ming-hui Zhao

JCI Insight. 2022 Dec 22; 7(24): e156748. Published online 2022 Dec 22. doi: 10.1172/jci.insight.156748

PMCID:: PMC9869976

Abstract Article PDF–16M

Select item 98402076.

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Maura A Crowley, Donita L Garland, Holger Sellner, Angela Banks, Lin Fan, Tomas Rejtar, Natasha Buchanan, Omar Delgado, Yong Yao Xu, Sandra Jose, Christopher M Adams, Muneto Mogi, Karen Wang, Chad E Bigelow, Stephen Poor, Karen Anderson, Bruce D Jaffee, Ganesh Prasanna, Cynthia Grosskreutz, Rosario Fernandez-Godino, Eric A Pierce, Thaddeus P Dryja, Sha-Mei Liao

Hum Mol Genet. 2023 Jan 15; 32(2): 204–217. Published online 2022 Aug 9. doi: 10.1093/hmg/ddac187

PMCID:: PMC9840207

Abstract Article PDF–1.8M

Select item 97801777.

Neutrophil complement receptor signaling is required for BAFF-dependent humoral responses in mice

Arun Cumpelik, Evan Cody, Samuel Mon-Wei Yu, Emilie K. Grasset, David Dominguez-Sola, Andrea Cerutti, Peter S. Heeger

J Immunol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: J Immunol. 2023 Jan 1; 210(1): 19–23. doi: 10.4049/jimmunol.2200410

PMCID:: PMC9780177

Abstract Article PDF–1.1M

Select item 85256508.

Complement factor B in high glucose–induced podocyte injury and diabetic kidney disease

Qingmiao Lu, Qing Hou, Kai Cao, Xiaoli Sun, Yan Liang, Mengru Gu, Xian Xue, Allan Zijian Zhao, Chunsun Dai

JCI Insight. 2021 Oct 8; 6(19): e147716. Published online 2021 Oct 8. doi: 10.1172/jci.insight.147716

PMCID:: PMC8525650

Abstract Article PDF–22M

Select item 85158639.

Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse

Sheila Cabezas-Falcon, Aidan J. Norbury, Jarrod Hulme-Jones, Sonja Klebe, Penelope Adamson, Penny A. Rudd, Suresh Mahalingam, Li-Ching Ong, Sylvie Alonso, David L. Gordon, Jillian M. Carr

J Gen Virol. 2021; 102(3): 001547. Published online 2021 Jan 7. doi: 10.1099/jgv.0.001547

PMCID:: PMC8515863

Abstract Article PDF–2.4M

Select item 843159510.

Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway

Hannah Murray, Beiying Qiu, Sze Yuan Ho, Xiaomeng Wang

Int J Mol Sci. 2021 Sep; 22(17): 9580. Published online 2021 Sep 3. doi: 10.3390/ijms22179580

PMCID:: PMC8431595

Abstract Article PDF–2.0M

Select item 826661711.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 803530112.

Complement component factor B has thrombin-like activity

Kazue Takahashi, Nirmal K. Banda, V. Michael Holers, Elizabeth M. Van Cott

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 May 7.

Published in final edited form as: Biochem Biophys Res Commun. 2021 May 7; 552: 17–22. Published online 2021 Mar 16. doi: 10.1016/j.bbrc.2021.02.134

PMCID:: PMC8035301

Abstract Article PDF–1.6M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 789242914.

Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis

Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose

Front Immunol. 2020; 11: 603924. Published online 2021 Feb 5. doi: 10.3389/fimmu.2020.603924

PMCID:: PMC7892429

Abstract Article PDF–1.1M

Select item 741006115.

Complement factor H–deficient mice develop spontaneous hepatic tumors

Jennifer Laskowski, Brandon Renner, Matthew C. Pickering, Natalie J. Serkova, Peter M. Smith-Jones, Eric T. Clambey, Raphael A. Nemenoff, Joshua M. Thurman

J Clin Invest. 2020 Aug 3; 130(8): 4039–4054. Published online 2020 Jun 22. doi: 10.1172/JCI135105

PMCID:: PMC7410061

Abstract Article PDF–23M

Select item 690740316.

The histone deacetylase SIRT6 restrains transcription elongation via promoter- proximal pausing

Jean-Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina Ferrer, Kenneth N. Ross, Jee-Eun Choi, Ann Samarakkody, Fei Ji, Andrew Chang, Ruslan I. Sadreyev, Sridhar Ramaswamy, Sergei Nechaev, Johnathan R. Whetstine, Robert G. Roeder, Karen Adelman, Alon Goren, Raul Mostoslavsky

Mol Cell. Author manuscript; available in PMC 2020 Aug 22.

Published in final edited form as: Mol Cell. 2019 Aug 22; 75(4): 683–699.e7. Published online 2019 Aug 6. doi: 10.1016/j.molcel.2019.06.034

PMCID:: PMC6907403

Abstract Article PDF–2.9M

Select item 669277017.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 668547818.

RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation

Hong‐Bin Liu, Tahir Muhammad, Yueshuai Guo, Meng‐Jing Li, Qian‐Qian Sha, Chuan‐Xin Zhang, Hui Liu, Shi‐Gang Zhao, Han Zhao, Hao Zhang, Yan‐Zhi Du, Kang Sun, Kui Liu, Gang Lu, Xue‐Jiang Guo, Jiahao Sha, Heng‐Yu Fan, Fei Gao, Zi‐Jiang Chen

Adv Sci (Weinh) 2019 Aug 7; 6(15): 1900295. Published online 2019 May 24. doi: 10.1002/advs.201900295

PMCID:: PMC6685478

Abstract Article PDF–3.0M

Select item 645951019.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 633346020.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

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