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Select item 109436911.

Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency

Patrick A. Flynn, Mark D. Long, Yoko Kosaka, Nicola Long, Jessica S. Mulkey, Jesse L. Coy, Anupriya Agarwal, Evan F. Lind

Front Immunol. 2024; 15: 1297338. Published online 2024 Mar 1. doi: 10.3389/fimmu.2024.1297338

PMCID:: PMC10943691

Abstract Article PDF–6.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109049953.

Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice

Chun I. Yu, Rick Maser, Florentina Marches, Jacques Banchereau, Karolina Palucka

iScience. 2024 Mar 15; 27(3): 109238. Published online 2024 Feb 15. doi: 10.1016/j.isci.2024.109238

PMCID:: PMC10904995

Abstract Article PDF–5.3M

Select item 107502684.

Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling

Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner, Ravi Bhatia

Leukemia. Author manuscript; available in PMC 2023 Dec 26.

Published in final edited form as: Leukemia. 2023 Mar; 37(3): 560–570. Published online 2022 Dec 22. doi: 10.1038/s41375-022-01798-5

PMCID:: PMC10750268

Abstract Article PDF–1.3M

Select item 104847915.

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

David Lara-Astiaso, Ainhoa Goñi-Salaverri, Julen Mendieta-Esteban, Nisha Narayan, Cynthia Del Valle, Torsten Gross, George Giotopoulos, Tumas Beinortas, Mar Navarro-Alonso, Laura Pilar Aguado-Alvaro, Jon Zazpe, Francesco Marchese, Natalia Torrea, Isabel A. Calvo, Cecile K. Lopez, Diego Alignani, Aitziber Lopez, Borja Saez, Jake P. Taylor-King, Felipe Prosper, Nikolaus Fortelny, Brian J. P. Huntly

Nat Genet. 2023; 55(9): 1542–1554. Published online 2023 Aug 14. doi: 10.1038/s41588-023-01471-2

PMCID:: PMC10484791

Abstract Article PDF–18M

Select item 102731716.

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski

Blood. 2023 May 11; 141(19): 2372–2389. Published online 2022 Dec 30. doi: 10.1182/blood.2022018428

PMCID:: PMC10273171

Abstract Article

Select item 100823807.

FLT3^ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation

Yanan Li, Wei Yang, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, Jonny Mendoza-Castrejon, Priscilla Rodriguez-Lopez, Jeffrey A. Magee

Blood. 2023 Mar 23; 141(12): 1442–1456. Published online 2022 Nov 21. doi: 10.1182/blood.2022016889

PMCID:: PMC10082380

Abstract Article

Select item 100795278.

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia

Jasmin Straube, Theresa Eifert, Therese Vu, Yashaswini Janardhanan, Rohit Haldar, Björn von Eyss, Leanne Cooper, Claudia Bruedigam, Victoria Y. Ling, Emily Cooper, Ann-Marie Patch, Lars Bullinger, Tina M. Schnoeder, Megan Bywater, Florian H. Heidel, Steven W. Lane

Leukemia. 2023; 37(4): 741–750. Published online 2023 Feb 4. doi: 10.1038/s41375-023-01832-0

PMCID:: PMC10079527

Abstract Article PDF–2.5M

Select item 99919239.

BET inhibitors rescue anti-PD1 resistance by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8⁺ T cells

Kyle A. Romine, Kevin MacPherson, Hyun-jun Cho, Yoko Kosaka, Patrick A. Flynn, Kaelan H. Byrd, Jesse L. Coy, Matthew T. Newman, Ravina Pandita, Christopher P. Loo, Jaime Scott, Andrew C. Adey, Evan F. Lind

Leukemia. 2023; 37(3): 580–592. Published online 2023 Jan 21. doi: 10.1038/s41375-023-01808-0

PMCID:: PMC9991923

Abstract Article PDF–3.4M

Select item 993630910.

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu

Blood. 2023 Jan 19; 141(3): 244–259. Published online 2022 Oct 11. doi: 10.1182/blood.2022016580

Correction in:: Blood. 2024 Jan 25; 143(4): 376.

PMCID:: PMC9936309

Abstract Article

Select item 953626911.

Combined heterozygosity of FLT3^ITD, TET2, and DNMT3A results in aggressive leukemia

Baskar Ramdas, Palam Lakshmi Reddy, Raghuveer Singh Mali, Santhosh Kumar Pasupuleti, Ji Zhang, Mark R. Kelley, Sophie Paczesny, Chi Zhang, Reuben Kapur

JCI Insight. 2022 Sep 8; 7(17): e162016. Published online 2022 Sep 8. doi: 10.1172/jci.insight.162016

PMCID:: PMC9536269

Abstract Article PDF–7.5M

Select item 933605712.

A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML

Baohuan Cai, Yun Liu, Yating Chong, Stephanie Fay Mori, Atsuko Matsunaga, Hualei Zhang, Xuexiu Fang, Chang-Sheng Chang, John K. Cowell, Tianxiang Hu

Mol Cancer. 2022; 21: 156. Published online 2022 Jul 29. doi: 10.1186/s12943-022-01628-3

PMCID:: PMC9336057

Abstract Article PDF–13M

Select item 929382313.

Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML)

Muhammed Burak Demircan, Tina M. Schnoeder, Peter C. Mgbecheta, Katrin Schröder, Frank-D. Böhmer, Florian H. Heidel

J Cancer Res Clin Oncol. 2022; 148(8): 1983–1990. Published online 2022 Mar 29. doi: 10.1007/s00432-022-03986-3

PMCID:: PMC9293823

Abstract Article PDF–3.1M

Select item 920223414.

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Sarah C. Nabinger, Sisi Chen, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Sasidhar Vemula, Aidan C. Fahey, Christine Wang, Cecil Daniels, H. Scott Boswell, George E. Sandusky, Lindsey D. Mayo, Reuben Kapur, Yan Liu

Leukemia. Author manuscript; available in PMC 2022 Jun 16.

Published in final edited form as: Leukemia. 2019 Jun; 33(6): 1535–1539. Published online 2019 Jan 23. doi: 10.1038/s41375-019-0377-0

PMCID:: PMC9202234

Article PDF–636K

Select item 916976715.

MicroRNA networks in FLT3-ITD acute myeloid leukemia

Dinh Hoa Hoang, Dandan Zhao, Sergio Branciamore, Davide Maestrini, Ivan R. Rodriguez, Ya-Huei Kuo, Russell Rockne, Samer K. Khaled, Bin Zhang, Le Xuan Truong Nguyen, Guido Marcucci

Proc Natl Acad Sci U S A. 2022 Apr 19; 119(16): e2112482119. Published online 2022 Apr 11. doi: 10.1073/pnas.2112482119

PMCID:: PMC9169767

Abstract Article PDF–3.0M

Select item 897981916.

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger, Nina Cabezas-Wallscheid, Melanie Boerries, Sebastian Halbach, Anna L. Illert, Tilman Brummer

Leukemia. 2022; 36(4): 970–982. Published online 2021 Dec 13. doi: 10.1038/s41375-021-01490-0

PMCID:: PMC8979819

Abstract Article PDF–4.7M

Select item 897331717.

Cytoplasmic DROSHA and Non-canonical Mechanisms of MiR-155 Biogenesis in FLT3-ITD Acute Myeloid Leukemia

Le Xuan Truong Nguyen, Bin Zhang, Dinh Hoa Hoang, Dandan Zhao, Huafeng Wang, Herman Wu, Yu-Lin Su, Haojie Dong, Sonia Rodriguez-Rodriguez, Brian Armstrong, Lucy Y. Ghoda, Danilo Perrotti, Flavia Pichiorri, Jianjun Chen, Ling Li, Marcin Kortylewski, Russell C. Rockne, Ya-Huei Kuo, Samer Khaled, Nadia Carlesso, Guido Marcucci

Leukemia. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Leukemia. 2021 Aug; 35(8): 2285–2298. Published online 2021 Feb 15. doi: 10.1038/s41375-021-01166-9

PMCID:: PMC8973317

Abstract Article PDF–3.1M

Select item 891744418.

IL7Rα, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells

Atesh K. Worthington, Taylor Cool, Donna M. Poscablo, Adeel Hussaini, Anna E. Beaudin, E. Camilla Forsberg

Development. 2022 Apr 15; 149(8): dev200139. Published online 2022 Jan 24. doi: 10.1242/dev.200139

PMCID:: PMC8917444

Abstract Article

Select item 888542219.

The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

Anne Charlet, Max Kappenstein, Philip Keye, Kathrin Kläsener, Cornelia Endres, Teresa Poggio, Sivahari P. Gorantla, Stefanie Kreutmair, Jana Sänger, Anna L. Illert, Cornelius Miething, Michael Reth, Justus Duyster, Christoph Rummelt, Nikolas von Bubnoff

Leukemia. 2022; 36(3): 701–711. Published online 2021 Nov 8. doi: 10.1038/s41375-021-01462-4

PMCID:: PMC8885422

Abstract Article PDF–2.2M

Select item 888541620.

A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation

Min Yang, Zengkai Pan, Kezhi Huang, Guntram Büsche, Hongyun Liu, Gudrun Göhring, Regina Rumpel, Oliver Dittrich-Breiholz, Steven Talbot, Michaela Scherr, Anuhar Chaturvedi, Matthias Eder, Julia Skokowa, Jianfeng Zhou, Karl Welte, Nils von Neuhoff, Ligen Liu, Arnold Ganser, Zhixiong Li

Leukemia. 2022; 36(3): 675–686. Published online 2021 Nov 3. doi: 10.1038/s41375-021-01452-6

PMCID:: PMC8885416

Abstract Article PDF–3.9M

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