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Select item 111157741.

Emerging roles for WNK kinases in cancer

Sónia Moniz, Peter Jordan

Cell Mol Life Sci. 2010 Apr; 67(8): 1265–1276. Published online 2010 Jan 22. doi: 10.1007/s00018-010-0261-6

PMCID:: PMC11115774

Article PDF–445K

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Article PDF–23M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Article PDF–2.9M

Select item 97696984.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Article PDF–2.7M

Select item 97281435.

Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics

Jian Yang, John E. Hall, Pedro A. Jose, Ken Chen, Chunyu Zeng

Pharmacol Ther. Author manuscript; available in PMC 2022 Dec 7.

Published in final edited form as: Pharmacol Ther. 2022 Nov; 239: 108194. Published online 2022 Apr 27. doi: 10.1016/j.pharmthera.2022.108194

PMCID:: PMC9728143

Article PDF–591K

Select item 97226636.

WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function

Hyun Ju Yoon, Gi-Cheon Kim, Sejin Oh, Hakhyun Kim, Yong Keon Kim, Yunji Lee, Min Seo Kim, Gino Kwon, Yeon-Su Ok, Ho-Keun Kwon, Hyun Seok Kim

Exp Mol Med. 2022 Nov; 54(11): 1913–1926. Published online 2022 Nov 10. doi: 10.1038/s12276-022-00876-z

PMCID:: PMC9722663

Article PDF–1.8M

Select item 96992837.

WNK kinases sense molecular crowding and rescue cell volume via phase separation

Cary R. Boyd-Shiwarski, Daniel J. Shiwarski, Shawn E. Griffiths, Rebecca T. Beacham, Logan Norrell, Daryl E. Morrison, Jun Wang, Jacob Mann, William Tennant, Eric N. Anderson, Jonathan Franks, Michael Calderon, Kelly A. Connolly, Muhammad Umar Cheema, Claire J. Weaver, Lubika J. Nkashama, Claire C. Weckerly, Katherine E. Querry, Udai Bhan Pandey, Christopher J. Donnelly, Dandan Sun, Aylin R. Rodan, Arohan R. Subramanya

Cell. Author manuscript; available in PMC 2023 Nov 23.

Published in final edited form as: Cell. 2022 Nov 23; 185(24): 4488–4506.e20. Published online 2022 Oct 31. doi: 10.1016/j.cell.2022.09.042

PMCID:: PMC9699283

Article PDF–3.7M

Select item 94754628.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Article PDF–4.6M

Select item 94616649.

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer

Liliang Shen, Junfeng Zhang, Zongtai Zheng, Fuhan Yang, Shenghua Liu, Yuan Wu, Yifan Chen, Tianyuan Xu, Shiyu Mao, Yang Yan, Wei Li, Wentao Zhang, Xudong Yao

Int J Biol Sci. 2022; 18(14): 5459–5474. Published online 2022 Aug 29. doi: 10.7150/ijbs.74546

PMCID:: PMC9461664

Article PDF–3.5M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Article PDF–3.3M

Select item 902299511.

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Zhuoyao Chen, Jinwei Zhang, Adrián R. Murillo-de-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E. Manning, Fiona J. Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock

Biochem J. 2022 Mar 18; 479(5): 661–675. Prepublished online 2022 Feb 18. Published online 2022 Mar 4. doi: 10.1042/BCJ20220019

PMCID:: PMC9022995

Article PDF–6.4M

Select item 856518012.

Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients

Nian Cao, Hui Tang, Miao Tian, Xue Gong, Zaicheng Xu, Binqing Zhou, Cong Lan, Caiyu Chen, Shuang Qu, Shuo Zheng, Hongmei Ren, Chao Fan, Pedro A. Jose, Chunyu Zeng, Tianyang Xia

Clin Exp Hypertens. Author manuscript; available in PMC 2022 Apr 3.

Published in final edited form as: Clin Exp Hypertens. 2021 Oct 3; 43(7): 597–603. Published online 2021 Apr 25. doi: 10.1080/10641963.2021.1919357

PMCID:: PMC8565180

Article PDF–858K

Select item 836418113.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Article PDF–3.0M

Select item 830162114.

Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang

Wenxi Jiang, Xizi Wang, Ronghui Li, Panpan Wang, Guangle Shan, Xiaodong Jia, Mingliang Gu

PLoS One. 2021; 16(7): e0255311. Published online 2021 Jul 23. doi: 10.1371/journal.pone.0255311

PMCID:: PMC8301621

Article PDF–1.3M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Article PDF–2.2M

Select item 816357616.

WNKs are potassium-sensitive kinases

John M. Pleinis, Logan Norrell, Radha Akella, John M. Humphreys, Haixia He, Qifei Sun, Feng Zhang, Jason Sosa-Pagan, Daryl E. Morrison, Jeffrey N. Schellinger, Laurie K. Jackson, Elizabeth J. Goldsmith, Aylin R. Rodan

Am J Physiol Cell Physiol. 2021 May 1; 320(5): C703–C721. Published online 2021 Jan 13. doi: 10.1152/ajpcell.00456.2020

PMCID:: PMC8163576

Article

Select item 802627917.

The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction

Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng

Eur Heart J. 2021 Apr 7; 42(14): 1415–1430. Published online 2020 Dec 6. doi: 10.1093/eurheartj/ehaa878

PMCID:: PMC8026279

Article PDF–1.7M

Select item 791400218.

A phosphorylated intermediate in the activation of WNK kinases

Radha Akella, Mateusz A. Drozdz, John M. Humphreys, Jenny Jiou, Mateusz Z. Durbacz, Zuhair J. Mohammed, Haixia He, Joanna Liwocha, Kamil Sekulski, Elizabeth J. Goldsmith

Biochemistry. Author manuscript; available in PMC 2021 Feb 27.

Published in final edited form as: Biochemistry. 2020 May 12; 59(18): 1747–1755. Published online 2020 Apr 24. doi: 10.1021/acs.biochem.0c00146

PMCID:: PMC7914002

Article PDF–1.4M

Select item 791042019.

Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension

Jian Yang, Van Anthony M. Villar, Pedro A. Jose, Chunyu Zeng

Antioxid Redox Signal. March 2021; 34(9): 716–735. Published online 2021 Feb 24. doi: 10.1089/ars.2020.8106

PMCID:: PMC7910420

Article PDF–619K

Select item 760600820.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Article PDF–2.5M

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