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Select item 111214641.

BMPR2 Loss Activates AKT by Disrupting DLL4/NOTCH1 and PPARγ Signaling in Pulmonary Arterial Hypertension

Keytam S. Awad, Shuibang Wang, Edward J. Dougherty, Ali Keshavarz, Cumhur Y. Demirkale, Zu Xi Yu, Latonia Miller, Jason M. Elinoff, Robert L. Danner

Int J Mol Sci. 2024 May; 25(10): 5403. Published online 2024 May 15. doi: 10.3390/ijms25105403

PMCID:: PMC11121464

Abstract Article PDF–6.9M

Select item 109316242.

Hemodynamic and Clinical Profiles of Pulmonary Arterial Hypertension Patients with GDF2 and BMPR2 Variants

Mei-Tzu Wang, Ken-Pen Weng, Sheng-Kai Chang, Wei-Chun Huang, Lee-Wei Chen

Int J Mol Sci. 2024 Mar; 25(5): 2734. Published online 2024 Feb 27. doi: 10.3390/ijms25052734

PMCID:: PMC10931624

Abstract Article PDF–4.6M

Select item 109168663.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 104126374.

Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension

Arun Jose, Jean M. Elwing, Steven M. Kawut, Michael W. Pauciulo, Kenneth E. Sherman, William C. Nichols, Michael B. Fallon, Francis X. McCormack

Commun Biol. 2023; 6: 826. Published online 2023 Aug 9. doi: 10.1038/s42003-023-05193-3

PMCID:: PMC10412637

Abstract Article PDF–3.2M

Select item 100085205.

Dysregulated Smooth Muscle Cell BMPR2 – ARRB2 Axis Causes Pulmonary Hypertension

Lingli Wang, Jan Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G Li, Nancy F Tojais, Shalina Taylor, David P Marciano, Pin-I Chen, Mingxia Gu, Dan Li, Rebecca L Harper, Nesrine El-Bizri, YuMee Kim, Kryn Stankunas, Marlene Rabinovitch

Circ Res. Author manuscript; available in PMC 2024 Mar 3.

Published in final edited form as: Circ Res. 2023 Mar 3; 132(5): 545–564. Published online 2023 Feb 6. doi: 10.1161/CIRCRESAHA.121.320541

PMCID:: PMC10008520

Abstract Article PDF–4.4M

Select item 98606016.

BMPR2 Variants Underlie Nonsyndromic Oligodontia

Jinglei Zheng, Haochen Liu, Miao Yu, Bichen Lin, Kai Sun, Hangbo Liu, Hailan Feng, Yang Liu, Dong Han

Int J Mol Sci. 2023 Jan; 24(2): 1648. Published online 2023 Jan 13. doi: 10.3390/ijms24021648

PMCID:: PMC9860601

Abstract Article PDF–4.2M

Select item 98572137.

PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension

Md Khadem Ali, Xuefei Tian, Lan Zhao, Katharina Schimmel, Christopher J. Rhodes, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter

Cells. 2023 Jan; 12(2): 316. Published online 2023 Jan 14. doi: 10.3390/cells12020316

PMCID:: PMC9857213

Abstract Article PDF–2.3M

Select item 97412768.

The Role of Bone Morphogenetic Protein Receptor Type 2 (BMPR2) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling

Anichavezhi Devendran, Sumanta Kar, Rasheed Bailey, Maria Giovanna Trivieri

Cells. 2022 Dec; 11(23): 3823. Published online 2022 Nov 29. doi: 10.3390/cells11233823

PMCID:: PMC9741276

Abstract Article PDF–4.9M

Select item 94872679.

Pulmonary arterial hypertension preceding idiopathic pulmonary fibrosis in a BMPR2 mutation positive patient

Aniek J. Raamsteeboers, Harm Jan Bogaard, Anton Vonk Noordegraaf

Eur Respir Rev. 2014 Mar; 23(131): 147–149. doi: 10.1183/09059180.00005513

PMCID:: PMC9487267

Article PDF–480K

Select item 924807510.

Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival

Max Schwiening, Emilia M. Swietlik, Divya Pandya, Keith Burling, Peter Barker, Oliver Y. Feng, Carmen M. Treacy, Susana Abreu, S. John Wort, Joanna Pepke-Zaba, Stefan Graf, Stefan J. Marciniak, Nicholas W. Morrell, Elaine Soon

Chest. 2022 Jun; 161(6): 1651–1656. Published online 2022 Jan 19. doi: 10.1016/j.chest.2022.01.019

PMCID:: PMC9248075

Article PDF–266K

Select item 923162311.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 916196112.

Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7

Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang, Huan-Ping Wang

Bioengineered. 2022; 13(4): 8538–8547. Published online 2022 Mar 24. doi: 10.1080/21655979.2022.2051840

PMCID:: PMC9161961

Abstract Article PDF–1.1M

Select item 914154813.

Reduction of BMPR2 mRNA Expression in Peripheral Blood of Pulmonary Arterial Hypertension Patients: A Marker for Disease Severity?

Vivienne Theobald, Nicola Benjamin, Hans-Jürgen Seyfarth, Michael Halank, Marc A. Schneider, Sarah Richtmann, Katrin Hinderhofer, Panagiota Xanthouli, Benjamin Egenlauf, Rebekka Seeger, Marius M. Hoeper, Danny Jonigk, Ekkehard Grünig, Christina A. Eichstaedt

Genes (Basel) 2022 May; 13(5): 759. Published online 2022 Apr 26. doi: 10.3390/genes13050759

PMCID:: PMC9141548

Abstract Article PDF–931K

Select item 906498614.

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M. Salmon, Randy J. Read, Peter ten Dijke, Nicholas W. Morrell, Wei Li

Nat Commun. 2022; 13: 2395. Published online 2022 May 3. doi: 10.1038/s41467-022-30111-2

PMCID:: PMC9064986

Abstract Article PDF–3.5M

Select item 881006415.

Effect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2

Xian Tao, Jiansheng Cheng, Xinghua Wang

Bioengineered. 2021; 12(2): 12625–12635. Published online 2021 Dec 13. doi: 10.1080/21655979.2021.2011015

PMCID:: PMC8810064

Abstract Article PDF–1.2M

Select item 866061616.

BMPR2 promoter methylation and its expression in valvular heart disease complicated with pulmonary artery hypertension

Ni Li, Linwen Zhu, Caimin Zhu, Hua Zhou, Dawei Zheng, Guodong Xu, Huoshun Shi, Jianqing Gao, Albert Jiarui Li, Zhaoyang Wang, Lebo Sun, Xiajun Li, Guofeng Shao

Aging (Albany NY) 2021 Nov 30; 13(22): 24580–24604. Published online 2021 Nov 18. doi: 10.18632/aging.203690

PMCID:: PMC8660616

Abstract Article PDF–2.5M

Select item 863683717.

The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

Huyi Liu, Xiangdao Cai, Jia Liu, Fengxiang Zhang, Andong He, Ruiman Li

Eur J Histochem. 2021 Nov 2; 65(4): 3323. Published online 2021 Nov 25. doi: 10.4081/ejh.2021.3323

PMCID:: PMC8636837

Abstract Article PDF–933K

Select item 846669418.

Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells

Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Elaine Langenfeld, Dongxuan Jia, Youyi Peng, John Gilleran, Jacques Roberge, Christopher Rongo, Salma K. Jabbour, John Langenfeld

Cell Commun Signal. 2021; 19: 97. Published online 2021 Sep 25. doi: 10.1186/s12964-021-00743-w

PMCID:: PMC8466694

Abstract Article PDF–3.9M

Select item 843162619.

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension

Malik Bisserier, Michael G. Katz, Carlos Bueno-Beti, Agnieszka Brojakowska, Shihong Zhang, Sarah Gubara, Erik Kohlbrenner, Shahood Fazal, Anthony Fargnoli, Peter Dorfmuller, Marc Humbert, Akiko Hata, David A. Goukassian, Yassine Sassi, Lahouaria Hadri

Int J Mol Sci. 2021 Sep; 22(17): 9105. Published online 2021 Aug 24. doi: 10.3390/ijms22179105

PMCID:: PMC8431626

Abstract Article PDF–6.6M

Select item 836810020.

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura

Nat Commun. 2021; 12: 4950. Published online 2021 Aug 16. doi: 10.1038/s41467-021-25248-5