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Select item 106764051.

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

Yonggan Sun, Qixing Nie, Shanshan Zhang, Huijun He, Sheng Zuo, Chunhua Chen, Jingrui Yang, Haihong Chen, Jielun Hu, Song Li, Jiaobo Cheng, Baojie Zhang, Zhitian Zheng, Shijie Pan, Ping Huang, Lu Lian, Shaoping Nie

Nat Commun. 2023; 14: 7740. Published online 2023 Nov 25. doi: 10.1038/s41467-023-43622-3

PMCID:: PMC10676405

Abstract Article PDF–5.4M

Select item 106511872.

Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death

Makoto Kuroda, Peter J Halfmann, Yoshihiro Kawaoka

J Infect Dis. 2023 Nov 15; 228(Suppl 7): S508–S513. Published online 2023 Aug 14. doi: 10.1093/infdis/jiad344

PMCID:: PMC10651187

Abstract Article PDF–476K

Select item 106302023.

β-羟基丁酸抑制肺腺癌细胞增殖、迁移及侵袭的作用机制

黄云龙, 朱玉峰, 石瑾, 刘蓉, 曾婷, 韩良辅

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Oct 20; 43(10): 1744–1751. Chinese. doi: 10.12122/j.issn.1673-4254.2023.10.12

PMCID:: PMC10630202

Abstract Article PDF–2.0M

Select item 106281044.

Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2

Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park

Nat Commun. 2023; 14: 7150. Published online 2023 Nov 6. doi: 10.1038/s41467-023-42764-8

PMCID:: PMC10628104

Abstract Article PDF–2.9M

Select item 86381845.

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases

Cierla McGuire Sams, Kasey Shepp, Jada Pugh, Madison R. Bishop, Nancy D. Merner

BMC Med Genomics. 2021; 14: 284. Published online 2021 Dec 1. doi: 10.1186/s12920-021-01126-3

PMCID:: PMC8638184

Abstract Article PDF–4.5M

Select item 85888346.

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics

Sakhila Ghimire, Daniela Weber, Katrin Hippe, Elisabeth Meedt, Matthias Hoepting, Anna-Sophia Kattner, Andreas Hiergeist, André Gessner, Carina Matos, Saroj Ghimire, Daniel Wolff, Matthias Edinger, Petra Hoffmann, Hendrik Poeck, Wolfgang Herr, Ernst Holler

Front Immunol. 2021; 12: 753287. Published online 2021 Oct 28. doi: 10.3389/fimmu.2021.753287

PMCID:: PMC8588834

Abstract Article PDF–12M

Select item 69901117.

Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway

Xiaocao Ma, Xin Luo, Shili Zhou, Yanxia Huang, Cancan Chen, Changbai Huang, Li Shen, Ping Zhang, Chao Liu

Front Cell Infect Microbiol. 2019; 9: 480. Published online 2020 Jan 22. doi: 10.3389/fcimb.2019.00480

PMCID:: PMC6990111

Abstract Article PDF–7.5M

Select item 63669698.

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Ravirajsinh N. Jadeja, Malita A. Jones, Ollya Fromal, Folami L. Powell, Sandeep Khurana, Nagendra Singh, Pamela M. Martin

Aging (Albany NY) 2019 Jan 31; 11(2): 386–400. Published online 2019 Jan 18. doi: 10.18632/aging.101743

PMCID:: PMC6366969

Abstract Article PDF–1.5M

Select item 44472299.

The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling

Daisuke Yasuda, Yuki Imura, Satoshi Ishii, Takao Shimizu, Motonao Nakamura

FASEB J. 2015 Jun; 29(6): 2412–2422. Published online 2015 Feb 17. doi: 10.1096/fj.14-267096

PMCID:: PMC4447229

Abstract Article

Select item 422303310.

Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2

Huawang Sun, Guo Li, Wenjuan Zhang, Qi Zhou, Yena Yu, Ying Shi, Stefan Offermanns, Jianxin Lu, Naiming Zhou

PLoS One. 2014; 9(11): e112310. Published online 2014 Nov 6. doi: 10.1371/journal.pone.0112310

PMCID:: PMC4223033

Abstract Article PDF–4.5M

Select item 420146411.

Upregulation of GPR109A in Parkinson’s Disease

Chandramohan Wakade, Raymond Chong, Eric Bradley, Bobby Thomas, John Morgan

PLoS One. 2014; 9(10): e109818. Published online 2014 Oct 17. doi: 10.1371/journal.pone.0109818

PMCID:: PMC4201464

Abstract Article PDF–1.1M

Select item 394462712.

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

Selvakumar Elangovan, Rajneesh Pathania, Sabarish Ramachandran, Sudha Ananth, Ravi N. Padia, Ling Lan, Nagendra Singh, Pamela M. Martin, Lesleyann Hawthorn, Puttur D. Prasad, Vadivel Ganapathy, Muthusamy Thangaraju

Cancer Res. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: Cancer Res. 2014 Feb 15; 74(4): 1166–1178. Published online 2013 Dec 26. doi: 10.1158/0008-5472.CAN-13-1451

PMCID:: PMC3944627

Abstract Article PDF–5.1M

Select item 364217513.

Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells

Joshua T. Chai, Janet E. Digby, Neil Ruparelia, Andrew Jefferson, Ashok Handa, Robin P. Choudhury

PLoS One. 2013; 8(5): e62934. Published online 2013 May 2. doi: 10.1371/journal.pone.0062934

PMCID:: PMC3642175

Abstract Article PDF–2.3M

Select item 363111714.

GPR109A and Vascular Inflammation

Joshua T. Chai, Janet E. Digby, Robin P. Choudhury

Curr Atheroscler Rep. 2013; 15(5): 325. Published online 2013 Mar 24. doi: 10.1007/s11883-013-0325-9

PMCID:: PMC3631117

Abstract Article PDF–306K

Select item 350262715.

Identification and Characterization of Distinct C-Terminal Domains of the Human Hydroxycarboxylic Acid Receptor-2 That Are Essential for Receptor Export, Constitutive Activity, Desensitization, and Internalization

Guo Li, Qi Zhou, Yena Yu, Linjie Chen, Ying Shi, Jiansong Luo, Jeffrey Benovic, Jianxin Lu, Naiming Zhou

Mol Pharmacol. 2012 Dec; 82(6): 1150–1161. doi: 10.1124/mol.112.081307

PMCID:: PMC3502627

Abstract Article PDF–3.2M

Select item 339259816.

Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent Mechanisms

Janet E. Digby, Fernando Martinez, Andrew Jefferson, Neil Ruparelia, Joshua Chai, Malgorzata Wamil, David R. Greaves, Robin P. Choudhury

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3): 669–676. Published online 2012 Jan 19. doi: 10.1161/ATVBAHA.111.241836