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Select item 111726671.

Expression of Wild-Type and Mutant Human TDP-43 in Yeast Inhibits TOROID (TORC1 Organized in Inhibited Domain) Formation and Autophagy Proportionally to the Levels of TDP-43 Toxicity

Sangeun Park, Sei-Kyoung Park, Susan W. Liebman

Int J Mol Sci. 2024 Jun; 25(11): 6258. Published online 2024 Jun 6. doi: 10.3390/ijms25116258

PMCID:: PMC11172667

Abstract Article PDF–2.1M

Select item 109416552.

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes

Yoshiaki Kamada, Chiharu Umeda, Yukio Mukai, Hokuto Ohtsuka, Yoko Otsubo, Akira Yamashita, Takahiro Kosugi

J Cell Sci. 2024 Feb 15; 137(4): jcs261625. Published online 2024 Feb 28. doi: 10.1242/jcs.261625

PMCID:: PMC10941655

Abstract Article

Select item 108724773.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107001384.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 102977005.

The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions

Janhavi A. Kolhe, Neethu L. Babu, Brian C. Freeman

Mol Cell. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Mol Cell. 2023 Jun 15; 83(12): 2035–2044.e7. Published online 2023 Jun 8. doi: 10.1016/j.molcel.2023.05.021

PMCID:: PMC10297700

Abstract Article PDF–2.0M

Select item 102922106.

Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin

Sanjeev Kumar Choudhry, Maxwell L. Neal, Song Li, Arti T. Navare, Trevor Van Eeuwen, Richard W. Wozniak, Fred D. Mast, Michael P. Rout, John D. Aitchison

J Cell Biol. 2023 Sep 4; 222(9): e202207060. Published online 2023 Jun 26. doi: 10.1083/jcb.202207060

PMCID:: PMC10292210

Abstract Article PDF–5.9M

Select item 96309867.

A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans

Phoebe Y T Lu, Alyssa C Kirlin, Maria J Aristizabal, Hilary T Brewis, Nancy Lévesque, Dheva T Setiaputra, Nikita Avvakumov, Joris J Benschop, Marian Groot Koerkamp, Frank C P Holstege, Nevan J Krogan, Calvin K Yip, Jacques Côté, Michael S Kobor

Genetics. 2022 Nov; 222(3): iyac136. Published online 2022 Sep 6. doi: 10.1093/genetics/iyac136

PMCID:: PMC9630986

Abstract Article PDF–2.2M

Select item 95745148.

Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress

Witold Jaworek, Marc Sylvester, Giovanna Cenini, Wolfgang Voos

J Biol Chem. 2022 Oct; 298(10): 102494. Published online 2022 Sep 15. doi: 10.1016/j.jbc.2022.102494

PMCID:: PMC9574514

Abstract Article PDF–1.9M

Select item 92860239.

Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion

Mark Mattingly, Chris Seidel, Sofía Muñoz, Yan Hao, Ying Zhang, Zhihui Wen, Laurence Florens, Frank Uhlmann, Jennifer L. Gerton

Curr Biol. 2022 Jul 11; 32(13): 2884–2896.e6. doi: 10.1016/j.cub.2022.05.019

PMCID:: PMC9286023

Abstract Article

Select item 920981110.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 903130911.

TORC1 Signaling Controls the Stability and Function of α-Arrestins Aly1 and Aly2

Ray W. Bowman, II, Eric M. Jordahl, Sydnie Davis, Stefanie Hedayati, Hannah Barsouk, Nejla Ozbaki-Yagan, Annette Chiang, Yang Li, Allyson F. O’Donnell

Biomolecules. 2022 Apr; 12(4): 533. Published online 2022 Mar 31. doi: 10.3390/biom12040533

PMCID:: PMC9031309

Abstract Article PDF–12M

Select item 898260012.

Bur1 functions with TORC1 for vacuole‐mediated cell cycle progression

Yui Jin, Natsuko Jin, Yu Oikawa, Ron Benyair, Michiko Koizumi, Thomas E Wilson, Yoshinori Ohsumi, Lois S Weisman

EMBO Rep. 2022 Apr; 23(4): e53477. Published online 2022 Feb 15. doi: 10.15252/embr.202153477

PMCID:: PMC8982600

Abstract Article PDF–2.2M

Select item 866458613.

TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae

Riley Horvath, Nicole Hawe, Cindy Lam, Konstantin Mestnikov, Mariam Eji-Lasisi, John Rohde, Ivan Sadowski

Genetics. 2021 Dec; 219(4): iyab168. Published online 2021 Oct 5. doi: 10.1093/genetics/iyab168

PMCID:: PMC8664586

Abstract Article PDF–1.2M

Select item 859956414.

Pterocarpus marsupium extract extends replicative lifespan in budding yeast

Mitchell B. Lee, Michael G. Kiflezghi, Mitsuhiro Tsuchiya, Brian Wasko, Daniel T. Carr, Priya A. Uppal, Katherine A. Grayden, Yordanos C. Elala, Tu Anh Nguyen, Jesse Wang, Priya Ragosti, Sunny Nguyen, Yan Ting Zhao, Deborah Kim, Socheata Thon, Irika Sinha, Thao T. Tang, Ngoc H. B. Tran, Thu H. B. Tran, Margarete D. Moore, Mary Ann K. Li, Karl Rodriguez, Daniel E. L. Promislow, Matt Kaeberlein

GeroScience. 2021 Oct; 43(5): 2595–2609. Published online 2021 Jul 23. doi: 10.1007/s11357-021-00418-x

Correction in:: GeroScience. 2022 Jun; 44(3): 1889.

PMCID:: PMC8599564

Abstract Article PDF–1.7M

Select item 856434615.

Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast

Fumi Kozu, Kanae Shirahama‐Noda, Yasuhiro Araki, Shintaro Kira, Hitoshi Niwa, Takeshi Noda

FEBS Open Bio. 2021 Nov; 11(11): 3090–3100. Published online 2021 Sep 29. doi: 10.1002/2211-5463.13302

PMCID:: PMC8564346

Abstract Article PDF–5.0M

Select item 844883916.

A glutamine sensor that directly activates TORC1

Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N. Noda, Kouhei Tsumoto, Tatsuya Maeda

Commun Biol. 2021; 4: 1093. Published online 2021 Sep 17. doi: 10.1038/s42003-021-02625-w

PMCID:: PMC8448839

Abstract Article PDF–1.4M

Select item 840818317.

Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation

Dimitra Aggeli, Yuping Li, Gavin Sherlock

Nat Commun. 2021; 12: 5193. Published online 2021 Aug 31. doi: 10.1038/s41467-021-25440-7

PMCID:: PMC8408183

Abstract Article PDF–75M

Select item 839657618.

Target of Rapamycin Complex 1 (TORC1), Protein Kinase A (PKA) and Cytosolic pH Regulate a Transcriptional Circuit for Lipid Droplet Formation

Vitor Teixeira, Telma S. Martins, William A. Prinz, Vítor Costa

Int J Mol Sci. 2021 Aug; 22(16): 9017. Published online 2021 Aug 20. doi: 10.3390/ijms22169017

PMCID:: PMC8396576

Abstract Article PDF–4.2M

Select item 816402719.

Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway

Paraskevi Kritsiligkou, Karol Nowicki-Osuch, Zorana Carter, Chris J. Kershaw, Declan R. Creamer, Alan J. Weids, Chris M. Grant

J Biol Chem. 2021 Jan-Jun; 296: 100690. Published online 2021 Apr 22. doi: 10.1016/j.jbc.2021.100690

PMCID:: PMC8164027

Abstract Article PDF–3.3M

Select item 810365020.

TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae

Mohammad Alfatah, Jin Huei Wong, Vidhya Gomathi Krishnan, Yong Cheow Lee, Quan Feng Sin, Corinna Jie Hui Goh, Kiat Whye Kong, Wei Ting Lee, Jacqueline Lewis, Shawn Hoon, Prakash Arumugam

BMC Biol. 2021; 19: 95. Published online 2021 May 6. doi: 10.1186/s12915-021-01030-3

PMCID:: PMC8103650

Abstract Article PDF–2.9M

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