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Select item 108724771.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107001382.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 102333683.

A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon

Nir Cohen, Naama Aviram, Maya Schuldiner

EMBO J. 2023 Jun; 42(11): e113385. Published online 2023 Apr 19. doi: 10.15252/embj.2022113385

PMCID:: PMC10233368

Abstract Article PDF–1.2M

Select item 101329714.

The Smc5/6 complex is a DNA loop-extruding motor

Biswajit Pradhan, Takaharu Kanno, Miki Umeda Igarashi, Mun Siong Loke, Martin Dieter Baaske, Jan Siu Kei Wong, Kristian Jeppsson, Camilla Björkegren, Eugene Kim

Nature. 2023; 616(7958): 843–848. Published online 2023 Apr 19. doi: 10.1038/s41586-023-05963-3

PMCID:: PMC10132971

Abstract Article PDF–5.8M

Select item 94584405.

Cryo-EM structure of the Smc5/6 holo-complex

Stephen T Hallett, Isabella Campbell Harry, Pascale Schellenberger, Lihong Zhou, Nora B Cronin, Jonathan Baxter, Thomas J Etheridge, Johanne M Murray, Antony W Oliver

Nucleic Acids Res. 2022 Sep 9; 50(16): 9505–9520. Published online 2022 Aug 22. doi: 10.1093/nar/gkac692

PMCID:: PMC9458440

Abstract Article PDF–6.8M

Select item 92860236.

Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion

Mark Mattingly, Chris Seidel, Sofía Muñoz, Yan Hao, Ying Zhang, Zhihui Wen, Laurence Florens, Frank Uhlmann, Jennifer L. Gerton

Curr Biol. 2022 Jul 11; 32(13): 2884–2896.e6. doi: 10.1016/j.cub.2022.05.019

PMCID:: PMC9286023

Abstract Article

Select item 92098117.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 91916438.

Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes

You Yu, Shibai Li, Zheng Ser, Huihui Kuang, Thane Than, Danying Guan, Xiaolan Zhao, Dinshaw J. Patel

Proc Natl Acad Sci U S A. 2022 Jun 7; 119(23): e2202799119. Published online 2022 Jun 1. doi: 10.1073/pnas.2202799119

PMCID:: PMC9191643

Abstract Article PDF–4.1M

Select item 83515419.

Acute ethanol stress induces sumoylation of conserved chromatin structural proteins in Saccharomyces cerevisiae

Amanda I. Bradley, Nicole M. Marsh, Heather R. Borror, Kaitlyn E. Mostoller, Amber I. Gama, Richard G. Gardner

Mol Biol Cell. 2021 May 15; 32(11): 1121–1133. doi: 10.1091/mbc.E20-11-0715

PMCID:: PMC8351541

Abstract Article PDF–4.4M

Select item 832796110.

Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding

Michael Taschner, Jérôme Basquin, Barbara Steigenberger, Ingmar B Schäfer, Young‐Min Soh, Claire Basquin, Esben Lorentzen, Markus Räschle, Richard A Scheltema, Stephan Gruber

EMBO J. 2021 Aug 2; 40(15): e107807. Published online 2021 Jun 30. doi: 10.15252/embj.2021107807

PMCID:: PMC8327961

Abstract Article PDF–5.6M

Select item 820879111.

Smc5/6 in the rDNA modulates lifespan independently of Fob1

Sarah Moradi‐Fard, Aditya Mojumdar, Megan Chan, Troy A.A. Harkness, Jennifer A. Cobb

Aging Cell. 2021 Jun; 20(6): e13373. Published online 2021 May 12. doi: 10.1111/acel.13373

PMCID:: PMC8208791

Abstract Article PDF–2.3M

Select item 812683312.

Integrative analysis reveals unique structural and functional features of the Smc5/6 complex

You Yu, Shibai Li, Zheng Ser, Tanmoy Sanyal, Koyi Choi, Bingbing Wan, Huihui Kuang, Andrej Sali, Alex Kentsis, Dinshaw J. Patel, Xiaolan Zhao

Proc Natl Acad Sci U S A. 2021 May 11; 118(19): e2026844118. Published online 2021 May 3. doi: 10.1073/pnas.2026844118

PMCID:: PMC8126833

Abstract Article PDF–2.3M

Select item 809623913.

Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex

Stephen T Hallett, Pascale Schellenberger, Lihong Zhou, Fabienne Beuron, Ed Morris, Johanne M Murray, Antony W Oliver

Nucleic Acids Res. 2021 May 7; 49(8): 4534–4549. Published online 2021 Apr 13. doi: 10.1093/nar/gkab234

PMCID:: PMC8096239

Abstract Article PDF–5.3M

Select item 803282714.

Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal, Dana Branzei

Nat Commun. 2021; 12: 2111. Published online 2021 Apr 8. doi: 10.1038/s41467-021-22217-w

PMCID:: PMC8032827

Abstract Article PDF–2.9M

Select item 784936815.

Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance

Shibai Li, Jacob N. Bonner, Bingbing Wan, Stephen So, Ashley Mutchler, Leticia Gonzalez, Xiaoyu Xue, Xiaolan Zhao

Genes Dev. 2021 Feb 1; 35(3-4): 261–272. doi: 10.1101/gad.344739.120

PMCID:: PMC7849368

Abstract Article PDF–5.3M

Select item 775888016.

Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction

Pilar Gutierrez-Escribano, Silvia Hormeño, Julene Madariaga-Marcos, Roger Solé-Soler, Francis J. O’Reilly, Kyle Morris, Clara Aicart-Ramos, Ricardo Aramayo, Alex Montoya, Holger Kramer, Juri Rappsilber, Jordi Torres-Rosell, Fernando Moreno-Herrero, Luis Aragon

Mol Cell. 2020 Dec 17; 80(6): 1039–1054.e6. doi: 10.1016/j.molcel.2020.11.012

PMCID:: PMC7758880

Abstract Article

Select item 771875117.

Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1

Elsbeth Sanders, Phoebe A. Nguyen, Cody M. Rogers, Matthew L. Bochman

G3 (Bethesda) 2020 Dec; 10(12): 4359–4368. Published online 2020 Oct 28. doi: 10.1534/g3.120.401709

PMCID:: PMC7718751

Abstract Article PDF–1.2M

Select item 750740218.

Systematic analysis of bypass suppression of essential genes

Jolanda van Leeuwen, Carles Pons, Guihong Tan, Zi Yang Wang, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Maykel Lopes, Matej Ušaj, Andreia Dos Santos Lopes, Natascha van Lieshout, Chad L Myers, Frederick P Roth, Patrick Aloy, Brenda J Andrews, Charles Boone

Mol Syst Biol. 2020 Sep; 16(9): e9828. Published online 2020 Sep 17. doi: 10.15252/msb.20209828