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Select item 112563921.

Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque

Fu-Jun Liao, Shao-Liang Shen, Hai-Long Bao, Hui Li, Quan-Wei Zhao, Long Chen, Cai-Wei Gong, Cheng-Zhu Xiong, Wu-Peng Liu, Wei Li, Da-Nan Liu

J Transl Med. 2024; 22: 668. Published online 2024 Jul 18. doi: 10.1186/s12967-024-05464-5

PMCID:: PMC11256392

Abstract Article PDF–10M

Select item 111388642.

Enzymology of NAD+ homeostasis in man

G. Magni, A. Amici, M. Emanuelli, G. Orsomando, N. Raffaelli, S. Ruggieri

Cell Mol Life Sci. 2004 Jan; 61(1): 19–34. doi: 10.1007/s00018-003-3161-1

PMCID:: PMC11138864

Abstract Article PDF–291K

Select item 99224683.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 87470244.

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen

Molecules. 2022 Jan; 27(1): 273. Published online 2022 Jan 2. doi: 10.3390/molecules27010273

PMCID:: PMC8747024

Abstract Article PDF–2.8M

Select item 86641295.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 83933846.

Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas

Gustavo Ignacio Vázquez Cervantes, Benjamín Pineda, Daniela Ramírez Ortega, Alelí Salazar, Dinora Fabiola González Esquivel, Daniel Rembao, Sergio Zavala Vega, Saúl Gómez-Manzo, Gonzalo Pérez de la Cruz, Verónica Pérez de la Cruz

Cells. 2021 Aug; 10(8): 2028. Published online 2021 Aug 8. doi: 10.3390/cells10082028

PMCID:: PMC8393384

Abstract Article PDF–3.4M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76547558.

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics

Daniel C. Maddison, Mónica Alfonso-Núñez, Aisha M. Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Flaviano Giorgini

PLoS Genet. 2020 Nov; 16(11): e1009129. Published online 2020 Nov 10. doi: 10.1371/journal.pgen.1009129

PMCID:: PMC7654755

Abstract Article PDF–2.7M

Select item 73418469.

Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Nick Hornigold, Karen R. Dunn, Rachel A. Craven, Alexandre Zougman, Sebastian Trainor, Rebecca Shreeve, Joanne Brown, Helen Sewell, Michael Shires, Margaret Knowles, Tsutomu Fukuwatari, Eamonn R. Maher, Julie Burns, Selina Bhattarai, Mini Menon, Alvis Brazma, Ghislaine Scelo, Lara Feulner, Yasser Riazalhosseini, Mark Lathrop, Adrian Harris, Peter J. Selby, Rosamonde E. Banks, Naveen S. Vasudev

Br J Cancer. 2020 Jul 7; 123(1): 137–147. Published online 2020 May 11. doi: 10.1038/s41416-020-0874-y

PMCID:: PMC7341846

Abstract Article PDF–1.3M

Select item 719126010.

Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

Tzu-Ting Huang, Ling-Ming Tseng, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Mei-Fang Tseng, Yuan-Ya Chang, Tzu-Yi Chiang, Yune-Fang Ueng, Hsin-Chen Lee, Ming-Shen Dai, Chun-Yu Liu

EBioMedicine. 2020 Apr; 54: 102717. Published online 2020 Apr 27. doi: 10.1016/j.ebiom.2020.102717

PMCID:: PMC7191260

Abstract Article PDF–5.3M

Select item 625176111.

Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders

Brent Wilkinson, Oleg Evgrafov, DongQing Zheng, Nicolas Hartel, James A. Knowles, Nicholas A. Graham, Justin Ichida, Marcelo P. Coba

Biol Psychiatry. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Biol Psychiatry. 2019 Feb 15; 85(4): 305–316. Published online 2018 May 23. doi: 10.1016/j.biopsych.2018.05.009

PMCID:: PMC6251761

Abstract Article PDF–1.6M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 526093913.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 508488314.

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria

Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H. Bräsen, Ian S.D. Roberts, Susan Sheehan, Holly Savage, Hermann Haller, Mario Schiffer

J Am Soc Nephrol. 2016 Nov; 27(11): 3271–3277. Published online 2016 Mar 28. doi: 10.1681/ASN.2015070835

PMCID:: PMC5084883

Abstract Article

Select item 499000415.

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder

CM Sellgren, ME Kegel, SE Bergen, CJ Ekman, S Olsson, M Larsson, MP Vawter, L Backlund, PF Sullivan, P Sklar, JW Smoller, PKE Magnusson, CM Hultman, L Walther-Jallow, CI Svensson, P Lichtenstein, M Schalling, G Engberg, S Erhardt, M Landén

Mol Psychiatry. Author manuscript; available in PMC 2016 Aug 18.

Published in final edited form as: Mol Psychiatry. 2014 Mar; 19(3): 334–341. Published online 2013 Mar 5. doi: 10.1038/mp.2013.11

PMCID:: PMC4990004

Abstract Article PDF–556K

Select item 487126816.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Kris Wilson, Jonathan P Hutchinson, Olivier Mirguet, Ann Walker, Benjamin Beaufils, Nicolas Ancellin, Lionel Trottet, Véronique Bénéton, Christopher G Mowat, Martin Wilkinson, Paul Rowland, Carl Haslam, Andrew McBride, Natalie ZM Homer, James E Baily, Matthew GF Sharp, O James Garden, Jeremy Hughes, Sarah EM Howie, Duncan S Holmes, John Liddle, John P Iredale

Nat Med. Author manuscript; available in PMC 2016 Jul 11.

Published in final edited form as: Nat Med. 2016 Feb; 22(2): 202–209. Published online 2016 Jan 11. doi: 10.1038/nm.4020