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Items: 1 to 20 of 145

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The glucose transporter 2 regulates CD8+ T cell function via environment sensing
Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina, Antonio D’Amati, Guosu Wang, Thanushiyan Poobalasingam, Maria Fankhaenel, Davide Lucchesi, Rachel Coleby, David Tarussio, Bernard Thorens, Robert J. Hearnden, M. Paula Longhi, Paul Grevitt, Madeeha H. Sheikh, Egle Solito, Susana A. Godinho, Michele Bombardieri, David M. Smith, Dianne Cooper, Asif J. Iqbal, Jeffrey C. Rathmell, Samuel Schaefer, Valle Morales, Katiuscia Bianchi, Giuseppe Danilo Norata, Federica M. Marelli-Berg
Nat Metab. 2023; 5(11): 1969–1985. Published online 2023 Oct 26. doi: 10.1038/s42255-023-00913-9
PMCID:
PMC10663157
AbstractArticlePDF–9.6M
3.
Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression
Nicola Morrice, Susanne Vainio, Kirsi Mikkola, Lidy van Aalten, Jennifer R. Gallagher, Michael L.J. Ashford, Alison D. McNeilly, Rory J. McCrimmon, Alexandra Grosfeld, Patricia Serradas, Jukka Koffert, Ewan R. Pearson, Pirjo Nuutila, Calum Sutherland
Mol Metab. 2023 Nov; 77: 101807. Published online 2023 Sep 16. doi: 10.1016/j.molmet.2023.101807
PMCID:
PMC10550722
AbstractArticlePDF–2.2M
4.
Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation
Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih
eLife. 2023; 12: e90006. Published online 2023 Aug 23. doi: 10.7554/eLife.90006
PMCID:
PMC10482429
AbstractArticlePDF–26M
5.
The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity
Eliana Toren, Jessica D. Kepple, Kristen V. Coutinho, Samuel O. Poole, Iztiba M. Deeba, Tanya H. Pierre, Yanping Liu, Maigen M. Bethea, Chad S. Hunter
Mol Metab. 2023 Oct; 76: 101785. Published online 2023 Aug 1. doi: 10.1016/j.molmet.2023.101785
PMCID:
PMC10448474
AbstractArticlePDF–4.8M
6.
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain
Vladimir Abarinov, Joshua A. Levine, Angela J. Churchill, Bryce Hopwood, Cailin S. Deiter, Michelle A. Guney, Kristen L. Wells, Jessica M. Schrunk, Yuchun Guo, Jennifer Hammelman, David K. Gifford, Mark A. Magnuson, Hynek Wichterle, Lori Sussel
Genes Dev. 2023 Jun 1; 37(11-12): 490–504. doi: 10.1101/gad.350569.123
PMCID:
PMC10393193
AbstractArticlePDF–22M
7.
DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity
Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan
Diabetes. 2023 May; 72(5): 575–589. Published online 2023 Jan 6. doi: 10.2337/db22-0506
Correction in:
Diabetes. 2023 Dec; 72(12): 1882.
PMCID:
PMC10130487
AbstractArticlePDF–1.8M
8.
Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2
Mitsunori Fujino, Naoki Morito, Takuto Hayashi, Masami Ojima, Shun Ishibashi, Akihiro Kuno, Seizo Koshiba, Kunihiro Yamagata, Satoru Takahashi
JCI Insight. 2023 Mar 22; 8(6): e163306. Published online 2023 Mar 22. doi: 10.1172/jci.insight.163306
PMCID:
PMC10070115
AbstractArticlePDF–14M
9.
Normal β-Cell Glut2 Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice
Siresha Bathina, Tumininu S. Faniyan, Lauren Bainbridge, Autumn Davis, Kavaljit H. Chhabra
Biomolecules. 2023 Mar; 13(3): 540. Published online 2023 Mar 16. doi: 10.3390/biom13030540
PMCID:
PMC10046365
AbstractArticlePDF–2.4M
10.
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting
M. J. Barahona, F. Langlet, G. Labouèbe, S. Croizier, A. Picard, Bernard Thorens, María A. García-Robles
Sci Rep. 2022; 12: 17717. Published online 2022 Oct 21. doi: 10.1038/s41598-022-22489-2
PMCID:
PMC9587252
AbstractArticlePDF–9.1M
11.
Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation
Uylissa A. Rodriguez, Shakti Dahiya, Michelle L. Raymond, Chenxi Gao, Christina P. Martins-Cargill, Jon D. Piganelli, George K. Gittes, Jing Hu, Farzad Esni
Development. 2022 Sep 1; 149(17): dev200761. Published online 2022 Sep 9. doi: 10.1242/dev.200761
PMCID:
PMC9482336
AbstractArticle
12.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
13.
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice
Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri
Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056
PMCID:
PMC9327737
AbstractArticlePDF–3.0M
14.
Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity
Leticia Maria de Souza Cordeiro, Lauren Bainbridge, Nagavardhini Devisetty, David H. McDougal, Dorien J. M. Peters, Kavaljit H. Chhabra
Diabetologia. Author manuscript; available in PMC 2023 Jun 1.
Published in final edited form as: Diabetologia. 2022 Jun; 65(6): 1032–1047. Published online 2022 Mar 15. doi: 10.1007/s00125-022-05676-8
PMCID:
PMC9081162
AbstractArticlePDF–1.8M
15.
Nutrient Transporter Gene Expression in the Early Conceptus—Implications From Two Mouse Models of Diabetic Pregnancy
Claudia Kappen, Claudia Kruger, Sydney Jones, J. Michael Salbaum
Front Cell Dev Biol. 2022; 10: 777844. Published online 2022 Apr 11. doi: 10.3389/fcell.2022.777844
PMCID:
PMC9035823
AbstractArticlePDF–5.7M
16.
Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function
Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Gergő Szanda, Sandra Glasmacher, Aviram Kogot-Levin, Rinat Abramovitch, Bernard Thorens, Jürg Gertsch, Gil Leibowitz, Joseph Tam
Nat Commun. 2022; 13: 1783. Published online 2022 Apr 4. doi: 10.1038/s41467-022-29124-8
PMCID:
PMC8980033
AbstractArticlePDF–6.2M
17.
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes
Nirav Florian Chhabra, Anna–Lena Amend, Aimée Bastidas-Ponce, Sibylle Sabrautzki, Marta Tarquis-Medina, Stephan Sachs, Marina Rubey, Bettina Lorenz-Depiereux, Annette Feuchtinger, Mostafa Bakhti, Heiko Lickert, Gerhard K.H. Przemeck, Martin Hrabě de Angelis
Mol Metab. 2021 Dec; 54: 101334. Published online 2021 Sep 4. doi: 10.1016/j.molmet.2021.101334
PMCID:
PMC8515296
AbstractArticlePDF–2.3M
18.
The phosphatidylserine flippase β-subunit Tmem30a is essential for normal insulin maturation and secretion
Yeming Yang, Kuanxiang Sun, Wenjing Liu, Xiao Li, Wanli Tian, Ping Shuai, Xianjun Zhu
Mol Ther. 2021 Sep 1; 29(9): 2854–2872. Published online 2021 Apr 23. doi: 10.1016/j.ymthe.2021.04.026
PMCID:
PMC8417432
AbstractArticlePDF–4.7M
19.
Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease
Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre
J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629
PMCID:
PMC8251562
AbstractArticlePDF–46M
20.
Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene
Ildem Akerman, Miguel Angel Maestro, Elisa De Franco, Vanessa Grau, Sarah Flanagan, Javier García-Hurtado, Gerhard Mittler, Philippe Ravassard, Lorenzo Piemonti, Sian Ellard, Andrew T. Hattersley, Jorge Ferrer
Cell Rep. 2021 Apr 13; 35(2): 108981. Published online 2021 Apr 13. doi: 10.1016/j.celrep.2021.108981
PMCID:
PMC8052186
AbstractArticle

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