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Items: 1 to 20 of 34

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling
Ying-Chun Shih, Hsueh-Fen Chen, Chia-Ying Wu, Yi-Ru Ciou, Chia-Wen Wang, Huai-Chia Chuang, Tse-Hua Tan
Nat Commun. 2024; 15: 532. Published online 2024 Jan 15. doi: 10.1038/s41467-024-44843-w
PMCID:
PMC10789758
AbstractArticlePDF–5.3M
3.
Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle
Wanni Zhao, Yansong Zhang, Siyuan Lin, Yajuan Li, Alan Jian Zhu, Hanping Shi, Min Liu
J Cachexia Sarcopenia Muscle. 2023 Jun; 14(3): 1454–1467. Published online 2023 Apr 13. doi: 10.1002/jcsm.13233
PMCID:
PMC10235883
AbstractArticlePDF–8.9M
4.
UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting
Song Gao, Guohua Zhang, Zicheng Zhang, James Z. Zhu, Li Li, Yong Zhou, George G. Rodney, Jr., Reem S. Abo-Zahrah, Lindsey Anderson, Jose M. Garcia, Yong Tae Kwon, Yi-Ping Li
Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43): e2200215119. Published online 2022 Oct 17. doi: 10.1073/pnas.2200215119
PMCID:
PMC9618047
AbstractArticlePDF–2.1M
5.
The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway
Tri T. M. Vu, Alexander Varshavsky
Biochemistry. Author manuscript; available in PMC 2020 Nov 17.
Published in final edited form as: Biochemistry. 2020 Aug 4; 59(30): 2796–2812. Published online 2020 Jul 21. doi: 10.1021/acs.biochem.0c00514
PMCID:
PMC7669821
AbstractArticlePDF–1.9M
6.
Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes
Judith Reichmann, Karen Dobie, Lisa M. Lister, James H. Crichton, Diana Best, Marie MacLennan, David Read, Eleanor S. Raymond, Chao-Chun Hung, Shelagh Boyle, Katsuhiko Shirahige, Howard J. Cooke, Mary Herbert, Ian R. Adams
J Cell Biol. 2020 May 4; 219(5): e201702123. Published online 2020 Mar 31. doi: 10.1083/jcb.201702123
PMCID:
PMC7199850
AbstractArticlePDF–5.6M
7.
The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin
Hao Xu, Jianjin Shi, Hang Gao, Ying Liu, Zhenxiao Yang, Feng Shao, Na Dong
EMBO J. 2019 Jul 1; 38(13): e101996. Published online 2019 May 6. doi: 10.15252/embj.2019101996
PMCID:
PMC6600268
AbstractArticlePDF–1.8M
8.
Physiological and pathophysiological characteristics of ataxin-3 isoforms
Daniel Weishäupl, Juliane Schneider, Barbara Peixoto Pinheiro, Corinna Ruess, Sandra Maria Dold, Felix von Zweydorf, Christian Johannes Gloeckner, Jana Schmidt, Olaf Riess, Thorsten Schmidt
J Biol Chem. 2019 Jan 11; 294(2): 644–661. Published online 2018 Nov 19. doi: 10.1074/jbc.RA118.005801
PMCID:
PMC6333899
AbstractArticlePDF–3.0M
9.
Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells
Marie MacLennan, Marta García-Cañadas, Judith Reichmann, Elena Khazina, Gabriele Wagner, Christopher J Playfoot, Carmen Salvador-Palomeque, Abigail R Mann, Paula Peressini, Laura Sanchez, Karen Dobie, David Read, Chao-Chun Hung, Ragnhild Eskeland, Richard R Meehan, Oliver Weichenrieder, Jose Luis García-Pérez, Ian R Adams
eLife. 2017; 6: e26152. Published online 2017 Aug 14. doi: 10.7554/eLife.26152
PMCID:
PMC5570191
AbstractArticlePDF–2.4M
10.
Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes
James H. Crichton, Christopher J. Playfoot, Marie MacLennan, David Read, Howard J. Cooke, Ian R. Adams
PLoS Genet. 2017 Jul; 13(7): e1006904. Published online 2017 Jul 14. doi: 10.1371/journal.pgen.1006904
PMCID:
PMC5533463
AbstractArticlePDF–32M
11.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
12.
Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2
Guohua Zhang, Ren-Kuo Lin, Yong Tae Kwon, Yi-Ping Li
FASEB J. 2013 Jul; 27(7): 2893–2901. doi: 10.1096/fj.12-222711
PMCID:
PMC3688742
AbstractArticle
13.
The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments
Konstantin I. Piatkov, Christopher S. Brower, Alexander Varshavsky
Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27): E1839–E1847. Published online 2012 Jun 5. doi: 10.1073/pnas.1207786109
PMCID:
PMC3390858
AbstractArticlePDF–1.7M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
Alternative Ubiquitin Activation/Conjugation Cascades Interact with N-end rule Ubiquitin Ligases to Control Degradation of RGS Proteins
Peter C.W. Lee, Mathew E. Sowa, Steven P. Gygi, J. Wade Harper
Mol Cell. Author manuscript; available in PMC 2012 Aug 5.
Published in final edited form as: Mol Cell. 2011 Aug 5; 43(3): 392–405. doi: 10.1016/j.molcel.2011.05.034
PMCID:
PMC3151487
AbstractArticlePDF–2.6M
16.
The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids
Eskeatnaf Mulugeta Achame, Evelyne Wassenaar, Jos W Hoogerbrugge, Esther Sleddens-Linkels, Marja Ooms, Zu-Wen Sun, Wilfred FJ van IJcken, J Anton Grootegoed, Willy M Baarends
BMC Genomics. 2010; 11: 367. Published online 2010 Jun 10. doi: 10.1186/1471-2164-11-367
PMCID:
PMC3091626
AbstractArticlePDF–1.9M
17.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
18.
The Ubiquitin Ligase Ubr2, a Recognition E3 Component of the N-End Rule Pathway, Stabilizes Tex19.1 during Spermatogenesis
Fang Yang, Yong Cheng, Jee Young An, Yong Tae Kwon, Sigrid Eckardt, N. Adrian Leu, K. John McLaughlin, Peijing Jeremy Wang
PLoS One. 2010; 5(11): e14017. Published online 2010 Nov 16. doi: 10.1371/journal.pone.0014017
PMCID:
PMC2982839
AbstractArticlePDF–2.5M
19.
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination
Jee Young An, Eun-A. Kim, Yonghua Jiang, Adriana Zakrzewska, Dong Eun Kim, Min Jae Lee, Inhee Mook-Jung, Yi Zhang, Yong Tae Kwon
Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5): 1912–1917. Published online 2010 Jan 11. doi: 10.1073/pnas.0910267107
PMCID:
PMC2836623
AbstractArticlePDF–1.4M
20.
The Substrate Recognition Domains of the N-end Rule Pathway
Takafumi Tasaki, Adriana Zakrzewska, Drew D. Dudgeon, Yonghua Jiang, John S. Lazo, Yong Tae Kwon
J Biol Chem. 2009 Jan 16; 284(3): 1884–1895. doi: 10.1074/jbc.M803641200
PMCID:
PMC2615520
AbstractArticlePDF–1.0M

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