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Items: 1 to 20 of 58

1.
Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis
Ahmad Mohd Faizal, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim
Front Endocrinol (Lausanne) 2024; 15: 1274376. Published online 2024 Mar 8. doi: 10.3389/fendo.2024.1274376
PMCID:
PMC10957552
AbstractArticlePDF–1.6M
2.
Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression
Shinya Sato, Megumi Miyazaki, Shinji Fukuda, Yukiko Mizutani, Yoichi Mizukami, Shigeki Higashiyama, Shintaro Inoue
J Biol Chem. 2023 Jun; 299(6): 104826. Published online 2023 May 16. doi: 10.1016/j.jbc.2023.104826
PMCID:
PMC10276149
AbstractArticlePDF–3.0M
3.
Downregulation of HAS-2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway
Junlong Yang, Liu Wang, Zhongjie Zhang, Qing Sun, Yuan Zhang
Int J Mol Med. 2023 Jul; 52(1): 57. Published online 2023 May 25. doi: 10.3892/ijmm.2023.5260
PMCID:
PMC10241152
AbstractArticlePDF–10M
4.
3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension
Victor Tseng, Scott D. Collum, Ayed Allawzi, Kathryn Crotty, Samantha Yeligar, Aaron Trammell, M. Ryan Smith, Bum-Yong Kang, Roy L. Sutliff, Jennifer L. Ingram, Soma S.S.K. Jyothula, Rajarajan A. Thandavarayan, Howard J. Huang, Eva S. Nozik, Eric J. Wagner, C. Michael Hart, Harry Karmouty-Quintana
Matrix Biol. Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: Matrix Biol. 2022 Aug; 111: 53–75. Published online 2022 Jun 4. doi: 10.1016/j.matbio.2022.06.001
PMCID:
PMC9676077
AbstractArticlePDF–2.3M
5.
The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2
Yungai Xiang, Guo Yu, Yuxia Song, Yan Li, Lanlan Cheng, Pengfen Li, Le Zhang, Meng Wang, Li Tan
Mol Cell Biol. 2022 Sep; 42(9): e00107-22. Published online 2022 Aug 8. doi: 10.1128/mcb.00107-22
PMCID:
PMC9476914
AbstractArticlePDF–2.3M
6.
GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2
Jing Wang, Fei Teng, Hongxia Chai, Caixia Zhang, Xiaolei Liang, Yongxiu Yang
BMC Cancer. 2021; 21: 456. Published online 2021 Apr 23. doi: 10.1186/s12885-021-08202-y
PMCID:
PMC8066949
AbstractArticlePDF–4.3M
7.
Hyaluronan Synthases’ Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells
Sebastian Reiprich, Elif Akova, Attila Aszódi, Veronika Schönitzer
Int J Mol Sci. 2021 Mar; 22(6): 3123. Published online 2021 Mar 18. doi: 10.3390/ijms22063123
PMCID:
PMC8003268
AbstractArticlePDF–5.5M
8.
The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades
Shuko Terazawa, Mariko Takada, Yoriko Sato, Hiroaki Nakajima, Genji Imokawa
Int J Mol Sci. 2021 Feb; 22(4): 2057. Published online 2021 Feb 19. doi: 10.3390/ijms22042057
PMCID:
PMC7922819
AbstractArticlePDF–13M
9.
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer
Mengsi Yu, Kainan Zhang, Song Wang, Li Xue, Zhaoyun Chen, Ning Feng, Conghua Ning, Lijuan Wang, Jing Li, Boke Zhang, Changcheng Yang, Zhaoxia Zhang
Biomed Res Int. 2021; 2021: 8861766. Published online 2021 Jan 6. doi: 10.1155/2021/8861766
PMCID:
PMC7806397
AbstractArticlePDF–1.8M
10.
Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2–AS1
Ilaria Caon, Barbara Bartolini, Paola Moretto, Arianna Parnigoni, Elena Caravà, Daiana L. Vitale, Laura Alaniz, Manuela Viola, Evgenia Karousou, Giancarlo De Luca, Vincent C. Hascall, Alberto Passi, Davide Vigetti
J Biol Chem. 2020 Mar 13; 295(11): 3485–3496. Published online 2020 Jan 13. doi: 10.1074/jbc.RA119.011982
PMCID:
PMC7076221
AbstractArticlePDF–1.9M
11.
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts
Hiroyuki Yoshida, Mika Aoki, Aya Komiya, Yoko Endo, Keigo Kawabata, Tomomi Nakamura, Shingo Sakai, Tetsuya Sayo, Yasunori Okada, Yoshito Takahashi
J Biol Chem. 2020 Feb 21; 295(8): 2483–2494. Published online 2020 Jan 16. doi: 10.1074/jbc.RA119.010457
PMCID:
PMC7039545
AbstractArticlePDF–2.8M
12.
Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan
Shinya Ishizuka, Saho Tsuchiya, Yoshifumi Ohashi, Kenya Terabe, Emily B. Askew, Naoko Ishizuka, Cheryl B. Knudson, Warren Knudson
J Biol Chem. 2019 Sep 13; 294(37): 13562–13579. Published online 2019 Jul 3. doi: 10.1074/jbc.RA119.008567
PMCID:
PMC6746454
AbstractArticlePDF–5.0M
13.
Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling
Young‐Heon Kim, Seung Bum Lee, Sehwan Shim, Areumnuri Kim, Ji‐Hye Park, Won‐Suk Jang, Sun‐Joo Lee, Jae Kyung Myung, Sunhoo Park, Su‐Jae Lee, Min‐Jung Kim
Cancer Sci. 2019 Jul; 110(7): 2226–2236. Published online 2019 Jun 12. doi: 10.1111/cas.14070
PMCID:
PMC6609812
AbstractArticlePDF–1.9M
14.
Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells
Xuanhao Xu, Lu Wang, Bofeng Liu, Wei Xie, Ye-Guang Chen
J Biol Chem. 2018 Nov 30; 293(48): 18444–18453. Published online 2018 Oct 3. doi: 10.1074/jbc.RA118.003688
PMCID:
PMC6290156
AbstractArticlePDF–4.1M
15.
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini, Sanna Pasonen-Seppänen
BMC Cancer. 2018; 18: 664. Published online 2018 Jun 18. doi: 10.1186/s12885-018-4569-1
PMCID:
PMC6006557
AbstractArticlePDF–12M
16.
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function
M Mehić, V K de Sa, S Hebestreit, C-H Heldin, P Heldin
Oncogenesis. 2017 Jun; 6(6): e348. Published online 2017 Jun 12. doi: 10.1038/oncsis.2017.45
PMCID:
PMC5519194
AbstractArticlePDF–3.8M
17.
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis
Yuejuan Li, Jiurong Liang, Ting Yang, Jessica Monterrosa Mena, Caijuan Huan, Ting Xie, Adrianne Kurkciyan, Ningshan Liu, Dianhua Jiang, Paul W. Noble
Matrix Biol. Author manuscript; available in PMC 2017 Sep 1.
Published in final edited form as: Matrix Biol. 2016 Sep; 55: 35–48. Published online 2016 Mar 15. doi: 10.1016/j.matbio.2016.03.004
PMCID:
PMC5383204
AbstractArticlePDF–1.3M
18.
Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis
Tiina Jokela, Riikka Kärnä, Leena Rauhala, Genevieve Bart, Sanna Pasonen-Seppänen, Sanna Oikari, Markku I. Tammi, Raija H. Tammi
J Biol Chem. 2017 Mar 24; 292(12): 4861–4872. Published online 2017 Feb 10. doi: 10.1074/jbc.M116.760322
PMCID:
PMC5377801
AbstractArticlePDF–1.9M
19.
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
Bogdan-Tiberius Preca, Karolina Bajdak, Kerstin Mock, Waltraut Lehmann, Vignesh Sundararajan, Peter Bronsert, Alexandra Matzge-Ogi, Véronique Orian-Rousseau, Simone Brabletz, Thomas Brabletz, Jochen Maurer, Marc P. Stemmler
Oncotarget. 2017 Feb 14; 8(7): 11530–11543. Published online 2017 Jan 9. doi: 10.18632/oncotarget.14563
PMCID:
PMC5355283
AbstractArticlePDF–14M
20.
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion
Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing Jiang
J Exp Clin Cancer Res. 2016; 35: 181. Published online 2016 Nov 25. doi: 10.1186/s13046-016-0458-0
PMCID:
PMC5123319
AbstractArticlePDF–3.0M

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