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Items: 1 to 20 of 52

1.
The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway
Yuhong Huang, Yi Fan Wang, Xiong Zhong Ruan, Chi Wai Lau, Li Wang, Yu Huang
J Lipid Res. 2024 Jan; 65(1): 100472. Published online 2023 Nov 9. doi: 10.1016/j.jlr.2023.100472
PMCID:
PMC10805670
AbstractArticlePDF–3.4M
2.
Hepatocyte SREBP signaling mediates clock communication within the liver
Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar
J Clin Invest. 2023 Apr 17; 133(8): e163018. Published online 2023 Apr 17. doi: 10.1172/JCI163018
PMCID:
PMC10104893
AbstractArticlePDF–1.6M
3.
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice
Guo Zheng, Yu Su, Li Wei, Yingcheng Yao, Yizhe Wang, Xiaoting Luo, Xing Wang, Xiong Z. Ruan, Danyang Li, Yaxi Chen
Cell Death Dis. 2023 Apr; 14(4): 249. Published online 2023 Apr 6. doi: 10.1038/s41419-023-05754-8
PMCID:
PMC10079761
AbstractArticlePDF–9.1M
4.
SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im
J Adv Res. 2023 Mar; 45: 1–13. Published online 2022 May 31. doi: 10.1016/j.jare.2022.05.013
PMCID:
PMC10006517
AbstractArticlePDF–4.3M
5.
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, Atsushi Umemura, Akiko Eguchi, Tsuneo Ikenoue, Yoshihiro Hirata, Motonari Uesugi, Ryosuke Tateishi, Keisuke Tateishi, Mitsuhiro Fujishiro, Kazuhiko Koike, Hayato Nakagawa
J Clin Invest. 2022 Jun 1; 132(11): e151895. Published online 2022 Jun 1. doi: 10.1172/JCI151895
PMCID:
PMC9151706
AbstractArticlePDF–28M
6.
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING–NF-κB Signaling Pathway
Xinyu Huang, Yingcheng Yao, Xiaoli Hou, Li Wei, Yuhan Rao, Yu Su, Guo Zheng, Xiong Z. Ruan, Danyang Li, Yaxi Chen
Cell Mol Gastroenterol Hepatol. 2022; 14(1): 1–26. Published online 2022 Mar 31. doi: 10.1016/j.jcmgh.2022.03.006
PMCID:
PMC9117819
AbstractArticlePDF–14M
7.
DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice
Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, Stanley Andrisse
J Endocrinol. 2021 Aug 1; 250(2): 49–65. Published online 2021 Jun 1. doi: 10.1530/JOE-21-0040
PMCID:
PMC8240729
AbstractArticlePDF–3.1M
8.
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome
Wei-Yuan Hsieh, Quan D. Zhou, Autumn G. York, Kevin J. Williams, Philip O. Scumpia, Eliza B. Kronenberger, Xen Ping Hoi, Baolong Su, Xun Chi, Viet L. Bui, Elvira Khialeeva, Amber Kaplan, Young Min Son, Ajit S. Divakaruni, Jie Sun, Stephen T. Smale, Richard A. Flavell, Steven J. Bensinger
Cell Metab. Author manuscript; available in PMC 2021 Jul 7.
Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 128–143.e5. Published online 2020 Jun 8. doi: 10.1016/j.cmet.2020.05.003
PMCID:
PMC7891175
AbstractArticlePDF–3.2M
9.
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
Quan D. Zhou, Xun Chi, Min Sub Lee, Wei Yuan Hsieh, Jonathan J. Mkrtchyan, An-Chieh Feng, Cuiwen He, Autumn G York, Viet L. Bui, Eliza B. Kronenberger, Alessandra Ferrari, Xu Xiao, Allison E. Daly, Elizabeth J. Tarling, Robert Damoiseaux, Philip O. Scumpia, Stephen T. Smale, Kevin J. Williams, Peter Tontonoz, Steven J. Bensinger
Nat Immunol. Author manuscript; available in PMC 2021 Jan 2.
Published in final edited form as: Nat Immunol. 2020 Jul; 21(7): 746–755. Published online 2020 Jun 8. doi: 10.1038/s41590-020-0695-4
PMCID:
PMC7778040
AbstractArticlePDF–4.4M
10.
Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold
Marine Adlanmerini, Bryce J. Carpenter, Jarrett R. Remsberg, Yann Aubert, Lindsey C. Peed, Hannah J. Richter, Mitchell A. Lazar
Proc Natl Acad Sci U S A. 2019 Sep 10; 116(37): 18691–18699. Published online 2019 Aug 26. doi: 10.1073/pnas.1909883116
PMCID:
PMC6744860
AbstractArticlePDF–1.3M
11.
Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms
Alus M. Xiaoli, Ziyi Song, Fajun Yang
J Biol Chem. 2019 Aug 23; 294(34): 12743–12753. Published online 2019 Jul 3. doi: 10.1074/jbc.RA119.009644
PMCID:
PMC6709622
AbstractArticlePDF–2.0M
12.
The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair
Anthony Kusnadi, Sung Ho Park, Ruoxi Yuan, Tania Pannellini, Eugenia Giannopoulou, David Oliver, Theresa Lu, Kyung-Hyun Park-Min, Lionel B. Ivashkiv
Immunity. Author manuscript; available in PMC 2020 Aug 20.
Published in final edited form as: Immunity. 2019 Aug 20; 51(2): 241–257.e9. Published online 2019 Jul 11. doi: 10.1016/j.immuni.2019.06.005
PMCID:
PMC6709581
AbstractArticlePDF–1.2M
13.
Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
Minzhe Guo, Yina Du, Jason J. Gokey, Samriddha Ray, Sheila M. Bell, Mike Adam, Parvathi Sudha, Anne Karina Perl, Hitesh Deshmukh, S. Steven Potter, Jeffrey A. Whitsett, Yan Xu
Nat Commun. 2019; 10: 37. Published online 2019 Jan 3. doi: 10.1038/s41467-018-07770-1
PMCID:
PMC6318311
AbstractArticlePDF–4.3M
14.
SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1
Jae-Ho Lee, Peter Phelan, Minsang Shin, Byung-Chul Oh, Xianlin Han, Seung-Soon Im, Timothy F. Osborne
Proc Natl Acad Sci U S A. 2018 Dec 26; 115(52): E12228–E12234. Published online 2018 Dec 10. doi: 10.1073/pnas.1813458115
PMCID:
PMC6310840
AbstractArticlePDF–1.3M
15.
Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes
Dongyin Guan, Ying Xiong, Patricia C. Borck, Cholsoon Jang, Paschalis-Thomas Doulias, Romeo Papazyan, Bin Fang, Chunjie Jiang, Yuxiang Zhang, Erika R. Briggs, Wenxiang Hu, David Steger, Harry Ischiropoulos, Joshua D. Rabinowitz, Mitchell A. Lazar
Cell. Author manuscript; available in PMC 2019 Aug 9.
Published in final edited form as: Cell. 2018 Aug 9; 174(4): 831–842.e12. Published online 2018 Jul 26. doi: 10.1016/j.cell.2018.06.031
PMCID:
PMC6086765
AbstractArticlePDF–1.0M
16.
Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman
Development. 2018 Jul 1; 145(13): dev162396. Published online 2018 Jul 9. doi: 10.1242/dev.162396
PMCID:
PMC6053657
AbstractArticle
17.
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
Li Zhang, Prashant Rajbhandari, Christina Priest, Jaspreet Sandhu, Xiaohui Wu, Ryan Temel, Antonio Castrillo, Thomas Q de Aguiar Vallim, Tamer Sallam, Peter Tontonoz
eLife. 2017; 6: e28766. Published online 2017 Oct 25. doi: 10.7554/eLife.28766
PMCID:
PMC5656429
AbstractArticlePDF–1.8M
18.
ER phospholipid composition modulates lipogenesis during feeding and in obesity
Xin Rong, Bo Wang, Elisa N.D. Palladino, Thomas Q. de Aguiar Vallim, David A. Ford, Peter Tontonoz
J Clin Invest. 2017 Oct 2; 127(10): 3640–3651. Published online 2017 Aug 28. doi: 10.1172/JCI93616
PMCID:
PMC5617651
AbstractArticlePDF–6.9M
19.
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis
Peer W.F. Karmaus, Andrés A. Herrada, Cliff Guy, Geoffrey Neale, Yogesh Dhungana, Lingyun Long, Peter Vogel, Julian Avila, Clary B. Clish, Hongbo Chi
J Exp Med. 2017 Sep 4; 214(9): 2629–2647. doi: 10.1084/jem.20161855
PMCID:
PMC5584119
AbstractArticlePDF–3.2M
20.
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ
Yuxiang Zhang, Romeo Papazyan, Manashree Damle, Bin Fang, Jennifer Jager, Dan Feng, Lindsey C. Peed, Dongyin Guan, Zheng Sun, Mitchell A. Lazar
Genes Dev. 2017 Jun 15; 31(12): 1202–1211. doi: 10.1101/gad.302323.117
PMCID:
PMC5558923
AbstractArticlePDF–3.7M

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