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Select item 116584721.

Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes

Iván Ballasch, Laura López-Molina, Marcos Galán-Ganga, Anna Sancho-Balsells, Irene Rodríguez-Navarro, Sara Borràs-Pernas, M. Angeles Rabadan, Wanqi Chen, Carlota Pastó-Pellicer, Francesca Flotta, Wang Maoyu, Joaquín Fernández-Irigoyen, Enrique Santamaría, Ruth Aguilar, Carlota Dobaño, Natalia Egri, Carla Hernandez, Miqueu Alfonso, Manel Juan, Jordi Alberch, Daniel del Toro, Belén Arranz, Josep M. Canals, Albert Giralt

J Neuroinflammation. 2024; 21: 326. Published online 2024 Dec 18. doi: 10.1186/s12974-024-03320-3

PMCID:: PMC11658472

Article PDF–8.8M

Select item 114330692.

Ikaros is a principal regulator of Aire⁺ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance

Jun Hyung Sin, Juliana Sucharov, Sujit Kashyap, Yi Wang, Irina Proekt, Xian Liu, Audrey V. Parent, Alexander Gupta, Philippe Kastner, Susan Chan, James M. Gardner, Vasilis Ntranos, Corey N. Miller, Mark S. Anderson, Hilde Schjerven, Michael R. Waterfield

Sci Immunol. Author manuscript; available in PMC 2024 Oct 27.

Published in final edited form as: Sci Immunol. 2023 Oct 27; 8(88): eabq3109. Published online 2023 Oct 27. doi: 10.1126/sciimmunol.abq3109

PMCID:: PMC11433069

Article PDF–2.9M

Select item 111317273.

Ikaros negatively regulates inducible nitric oxide synthase expression in macrophages: Involvement of Ikaros phosphorylation by casein kinase 2

S.-J. Cho, J.-E. Huh, J. Song, D.-K. Rhee, S. Pyo

Cell Mol Life Sci. 2008 Oct; 65(20): 3290–3303. Published online 2008 Sep 27. doi: 10.1007/s00018-008-8332-7

PMCID:: PMC11131727

Article PDF–1.6M

Select item 110428064.

Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

Rajan M Thomas, Matthew C Pahl, Liqing Wang, Struan FA Grant, Wayne W Hancock, Andrew D Wells

eLife. 2024; 12: RP91392. Published online 2024 Apr 24. doi: 10.7554/eLife.91392

PMCID:: PMC11042806

Article PDF–18M

Select item 109015135.

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang

eLife. 2024; 13: e86168. Published online 2024 Feb 12. doi: 10.7554/eLife.86168

PMCID:: PMC10901513

Article PDF–9.2M

Select item 108959286.

Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS

Yeguang Hu, Daniela Salgado Figueroa, Zhihong Zhang, Margaret Veselits, Sourya Bhattacharyya, Mariko Kashiwagi, Marcus R Clark, Bruce A Morgan, Ferhat Ay, Katia Georgopoulos

Cell. Author manuscript; available in PMC 2024 Nov 22.

Published in final edited form as: Cell. 2023 Nov 22; 186(24): 5269–5289.e22. doi: 10.1016/j.cell.2023.10.023

PMCID:: PMC10895928

Article PDF–4.2M

Select item 104697407.

Impaired tissue homing by the Ikzf3^N159S variant is mediated by interfering with Ikaros function

Jingjie Chang, Motoi Yamashita, Aditya K. Padhi, Kam Y. J. Zhang, Ichiro Taniuchi

Front Immunol. 2023; 14: 1239779. Published online 2023 Aug 17. doi: 10.3389/fimmu.2023.1239779

PMCID:: PMC10469740

Article PDF–5.1M

Select item 97046898.

Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

Kentaro Kadono, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Hidenobu Kojima, Kenneth J. Dery, Xiaoling Li, Jerzy W. Kupiec-Weglinski

J Hepatol. Author manuscript; available in PMC 2022 Nov 28.

Published in final edited form as: J Hepatol. 2022 Apr; 76(4): 896–909. Published online 2021 Dec 3. doi: 10.1016/j.jhep.2021.11.026

PMCID:: PMC9704689

Article PDF–3.6M

Select item 89188089.

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

Zihao Su, Ziwu Wang, Susan Lindtner, Lin Yang, Zicong Shang, Yu Tian, Rongliang Guo, Yan You, Wenhao Zhou, John L. Rubenstein, Zhengang Yang, Zhuangzhi Zhang

Development. 2022 Feb 15; 149(4): dev200035. Published online 2022 Feb 23. doi: 10.1242/dev.200035

PMCID:: PMC8918808

Article

Select item 871664110.

Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice

Kerri R. Thomas, Eric J. Allenspach, Nathan D. Camp, Michelle N. Wray-Dutra, Socheath Khim, Anna Zielinska-Kwiatkowska, Andrew E. Timms, Joseph P. Loftus, H. Denny Liggitt, Katia Georgopoulos, Sarah K. Tasian, Richard G. James, David J. Rawlings

Leukemia. Author manuscript; available in PMC 2022 Jan 6.

Published in final edited form as: Leukemia. 2022 Jan; 36(1): 42–57. Published online 2021 Jun 30. doi: 10.1038/s41375-021-01326-x

PMCID:: PMC8716641

Article PDF–2.9M

Select item 852881911.

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida

Commun Biol. 2021; 4: 1204. Published online 2021 Oct 20. doi: 10.1038/s42003-021-02734-6

PMCID:: PMC8528819

Article PDF–3.6M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 812702313.

Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters

Ann C. Zovein, Kirsten A. Turlo, Ryan M. Ponec, Maureen R. Lynch, Kevin C. Chen, Jennifer J. Hofmann, Timothy C. Cox, Judith C. Gasson, M. Luisa Iruela-Arispe

Blood. Author manuscript; available in PMC 2021 May 17.

Published in final edited form as: Blood. 2010 Nov 4; 116(18): 3435–3444. Published online 2010 Aug 10. doi: 10.1182/blood-2010-04-279497

PMCID:: PMC8127023

Article PDF–3.5M

Select item 809260414.

CD4⁺ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate

Chiara Bernardi, Gaëtan Maurer, Tao Ye, Patricia Marchal, Bernard Jost, Manuela Wissler, Ulrich Maurer, Philippe Kastner, Susan Chan, Céline Charvet

Proc Natl Acad Sci U S A. 2021 Apr 27; 118(17): e2023172118. Published online 2021 Apr 23. doi: 10.1073/pnas.2023172118

PMCID:: PMC8092604

Article PDF–3.3M

Select item 802608415.

IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling

Maud Lemarié, Stefania Bottardi, Lionel Mavoungou, Helen Pak, Eric Milot

PLoS Genet. 2021 Mar; 17(3): e1009478. Published online 2021 Mar 26. doi: 10.1371/journal.pgen.1009478

PMCID:: PMC8026084

Article PDF–4.5M

Select item 798782816.

A point mutation in IKAROS ZF1 causes a B cell deficiency in mice

Brigette Boast, Lisa A. Miosge, Hye Sun Kuehn, Vicky Cho, Vicki Athanasopoulos, Hayley A. McNamara, Yovina Sontani, Yan Mei, Debbie Howard, Henry J. Sutton, Sofia A. Omari, Zhijia Yu, Mariam Nasreen, T. Daniel Andrews, Ian A. Cockburn, Christopher C. Goodnow, Sergio D. Rosenzweig, Anselm Enders

J Immunol. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: J Immunol. 2021 Apr 1; 206(7): 1505–1514. Published online 2021 Mar 3. doi: 10.4049/jimmunol.1901464

PMCID:: PMC7987828

Article PDF–973K

Select item 782633017.

An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis

Christian C. D. Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhrí P. Jackson, Justin A. Shyer, Holly R. Steach, Yuval Kluger, Loyal A. Goff, John L. Rinn, Adam Williams, Jorge Henao-Mejia, Richard A. Flavell

Proc Natl Acad Sci U S A. 2021 Jan 19; 118(3): e1918062118. Published online 2021 Jan 14. doi: 10.1073/pnas.1918062118

PMCID:: PMC7826330

Article PDF–1.9M

Select item 779040418.

Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds

Vincent U. Gant, Jacob J. Junco, Maci Terrell, Raushan Rashid, Karen R. Rabin

PLoS One. 2021; 16(1): e0244863. Published online 2021 Jan 7. doi: 10.1371/journal.pone.0244863

PMCID:: PMC7790404

Article PDF–2.0M

Select item 729223919.

Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling

Ipsita Guha, Avishek Bhuniya, Divanshu Shukla, Ashok Patidar, Partha Nandi, Akata Saha, Shayani Dasgupta, Nilanjan Ganguly, Sweta Ghosh, Arathi Nair, Subrata Majumdar, Bhaskar Saha, Walter J. Storkus, Rathindranath Baral, Anamika Bose

Front Immunol. 2020; 11: 898. Published online 2020 Jun 5. doi: 10.3389/fimmu.2020.00898

PMCID:: PMC7292239

Article PDF–18M

Select item 725041620.

Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene

Jaafar Alomairi, Anne M. Molitor, Nori Sadouni, Saadat Hussain, Magali Torres, Wiam Saadi, Lan T. M. Dao, Guillaume Charbonnier, David Santiago-Algarra, Jean Christophe Andrau, Denis Puthier, Tom Sexton, Salvatore Spicuglia

PLoS One. 2020; 15(5): e0233191. Published online 2020 May 26. doi: 10.1371/journal.pone.0233191

Correction in:: PLoS One. 2020; 15(6): e0235578.

PMCID:: PMC7250416

Article PDF–2.5M

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