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Select item 114530471.

Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance

Yiting Mao, Yicong Meng, Kexin Zou, Ningxin Qin, Yinyu Wang, Jing Yan, PinJia Chen, Yi Cheng, Weihui Shi, Chengliang Zhou, Huixi Chen, Jianzhong Sheng, Xinmei Liu, Jiexue Pan, Hefeng Huang

J Neuroinflammation. 2024; 21: 249. Published online 2024 Oct 4. doi: 10.1186/s12974-024-03248-8

PMCID:: PMC11453047

Abstract Article PDF–8.9M

Select item 114160102.

YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice

Chaopeng Ou, Kun Zhang, Yanyu Mu, Zhenzhen Huang, Xile Li, Wan Huang, Yan Wang, Weian Zeng, Handong Ouyang

BMC Med. 2024; 22: 406. Published online 2024 Sep 20. doi: 10.1186/s12916-024-03634-2

PMCID:: PMC11416010

Abstract Article PDF–18M

Select item 106889893.

USP47 inhibits m⁶A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis

Aiting Wang, Haiyan Huang, Jian-Hong Shi, Xiaoyan Yu, Rui Ding, Yuerong Zhang, Qiaoqiao Han, Zhi-Yu Ni, Xia Li, Ren Zhao, Qiang Zou

J Clin Invest. 2023 Dec 1; 133(23): e169365. Published online 2023 Dec 1. doi: 10.1172/JCI169365

PMCID:: PMC10688989

Abstract Article PDF–2.8M

Select item 105877694.

YTHDF1 mitigates acute kidney injury via safeguarding m⁶A-methylated mRNAs in stress granules of renal tubules

Wenwen Yang, Mingchao Zhang, Jiacheng Li, Shuang Qu, Fenglian Zhou, Minghui Liu, Limin Li, Zhihong Liu, Ke Zen

Redox Biol. 2023 Nov; 67: 102921. Published online 2023 Oct 13. doi: 10.1016/j.redox.2023.102921

PMCID:: PMC10587769

Abstract Article PDF–13M

Select item 105436435.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Abstract Article PDF–3.9M

Select item 104114756.

The m⁶A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m⁶A dependent manner

Meng-Yun Ke, Yi Fang, Hui Cai, Jian-Wen Lu, Lin Yang, Yue Wang, Rong-Qian Wu, Xu-Feng Zhang, Yi Lv, Jian Dong

Int J Biol Sci. 2023; 19(12): 3987–4003. Published online 2023 Jul 31. doi: 10.7150/ijbs.84768

PMCID:: PMC10411475

Abstract Article PDF–8.6M

Select item 103595387.

Targeting m⁶A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu

Gut. 2023 Aug; 72(8): 1497–1509. Published online 2023 Jan 30. doi: 10.1136/gutjnl-2022-328845

PMCID:: PMC10359538

Abstract Article PDF–13M

Select item 100115198.

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice

Sujun Yan, Xiaoling Zhou, Canlan Wu, Yunyi Gao, Yu Qian, Jingyu Hou, Renxiang Xie, Bing Han, Zhanghui Chen, Saisai Wei, Xiangwei Gao

Nat Commun. 2023; 14: 1379. Published online 2023 Mar 13. doi: 10.1038/s41467-023-37100-z

PMCID:: PMC10011519

Abstract Article PDF–11M

Select item 99668609.

YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice

Peizan Huang, Min Liu, Jing Zhang, Xiang Zhong, Chunlong Zhong

Int J Mol Sci. 2023 Feb; 24(4): 4240. Published online 2023 Feb 20. doi: 10.3390/ijms24044240

PMCID:: PMC9966860

Abstract Article PDF–4.5M

Select item 986395410.

Yth m⁶A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1

Diwen Shi, Xiaohan Liu, Xinyun Li, Tian Li, Jie Liu, Lin Wu

Int J Mol Sci. 2023 Jan; 24(2): 1741. Published online 2023 Jan 16. doi: 10.3390/ijms24021741

PMCID:: PMC9863954

Abstract Article PDF–3.4M

Select item 941891611.

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs

Fugui Niu, Pengfei Che, Zhuoxuan Yang, Jian Zhang, Lixin Yang, Mengru Zhuang, Xijun Ou, Sheng-Jian Ji

iScience. 2022 Sep 16; 25(9): 104908. Published online 2022 Aug 11. doi: 10.1016/j.isci.2022.104908

PMCID:: PMC9418916

Abstract Article PDF–7.5M

Select item 930101112.

The Maternal Microbiome Programs the m⁶A Epitranscriptome of the Mouse Fetal Brain and Intestine

Zhuoyu Xiao, Sun Liu, Zengguang Li, Jinru Cui, Hailan Wang, Zihan Wang, Qihuan Ren, Laixin Xia, Zhijian Wang, Yuan Li

Front Cell Dev Biol. 2022; 10: 882994. Published online 2022 Jul 7. doi: 10.3389/fcell.2022.882994

PMCID:: PMC9301011

Abstract Article PDF–2.5M

Select item 910855113.

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation

Amalie Grenov, Hadas Hezroni, Lior Lasman, Jacob H. Hanna, Ziv Shulman

Cell Rep. 2022 May 3; 39(5): 110778. Published online 2022 May 6. doi: 10.1016/j.celrep.2022.110778

PMCID:: PMC9108551

Abstract Article

Select item 906637014.

Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells

Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng

J Immunother Cancer. 2022; 10(2): e003663. Published online 2022 Feb 22. doi: 10.1136/jitc-2021-003663

PMCID:: PMC9066370

Abstract Article PDF–12M

Select item 890680715.

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

Fugui Niu, Peng Han, Jian Zhang, Yuanchu She, Lixin Yang, Jun Yu, Mengru Zhuang, Kezhen Tang, Yuwei Shi, Baisheng Yang, Chunqiao Liu, Bo Peng, Sheng-Jian Ji

eLife. 2022; 11: e75827. Published online 2022 Feb 18. doi: 10.7554/eLife.75827

PMCID:: PMC8906807

Abstract Article PDF–14M

Select item 882193716.

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease

Zishan Peng, Yingying Gong, Xuejie Wang, Weiman He, Liting Wu, Luyao Zhang, Li Xiong, Yanrui Huang, Lei Su, Peijie Shi, Xiaopei Cao, Rengyun Liu, Yanbing Li, Haipeng Xiao

Mol Ther. 2022 Feb 2; 30(2): 932–946. Published online 2021 Sep 20. doi: 10.1016/j.ymthe.2021.09.016

PMCID:: PMC8821937

Abstract Article PDF–4.4M

Select item 866669917.

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Ane Olazagoitia-Garmendia, Linda Zhang, Paula Mera, Julie K Godbout, Maialen Sebastian-DelaCruz, Iraia Garcia-Santisteban, Luis Manuel Mendoza, Alain Huerta, Iñaki Irastorza, Govind Bhagat, Peter H Green, Laura Herrero, Dolors Serra, Jose Antonio Rodriguez, Elena F Verdu, Chuan He, Jose Ramon Bilbao, Ainara Castellanos-Rubio

Gut. 2022 Jan; 71(1): 68–76. Published online 2021 Feb 1. doi: 10.1136/gutjnl-2020-322566

PMCID:: PMC8666699

Abstract Article PDF–2.1M

Select item 859612618.

The m⁶A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng‐Jian Ji

Adv Sci (Weinh) 2021 Nov; 8(22): 2101329. Published online 2021 Oct 12. doi: 10.1002/advs.202101329

PMCID:: PMC8596126

Abstract Article PDF–7.9M

Select item 859005119.

The m⁶A “reader” YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839

Tao Liu, Xinfeng Zheng, Chenglong Wang, Chuandong Wang, Shengdan Jiang, Bo Li, Pengbo Chen, Wenning Xu, Huoliang Zheng, Runze Yang, Xingxu Huang, Xiaoling Zhang, Leisheng Jiang

Cell Death Dis. 2021 Nov; 12(11): 1078. Published online 2021 Nov 12. doi: 10.1038/s41419-021-04312-4

PMCID:: PMC8590051

Abstract Article PDF–5.3M

Select item 809881420.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622