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Select item 81977901.

Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect

Ssu-Ju Fu, Meng-Chun Hu, Cheng-Tsung Hsiao, An-Ting Cheng, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang

Int J Mol Sci. 2021 Jun; 22(11): 5859. Published online 2021 May 30. doi: 10.3390/ijms22115859

PMCID:: PMC8197790

Abstract Article PDF–5.7M

Select item 79490932.

Cellular basis of ClC-2 Cl⁻ channel–related brain and testis pathologies

Corinna Göppner, Audrey H. Soria, Maja B. Hoegg-Beiler, Thomas J. Jentsch

J Biol Chem. 2021 Jan-Jun; 296: 100074. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.016031

PMCID:: PMC7949093

Abstract Article PDF–5.4M

Select item 74648693.

Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action

Marcelo A. Catalán, Francisca Julio-Kalajzić, María Isabel Niemeyer, Luis Pablo Cid, Francisco V. Sepúlveda

Cells. 2020 Aug; 9(8): 1781. Published online 2020 Jul 26. doi: 10.3390/cells9081781

PMCID:: PMC7464869

Abstract Article PDF–1.4M

Select item 73489784.

CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy

Ssu-Ju Fu, Meng-Chun Hu, Yi-Jheng Peng, Hsin-Yu Fang, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang

Cells. 2020 Jun; 9(6): 1332. Published online 2020 May 26. doi: 10.3390/cells9061332

PMCID:: PMC7348978

Abstract Article PDF–5.6M

Select item 72270285.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 68561926.

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jörg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stölting, Ute Scholl

Nat Commun. 2019; 10: 5155. Published online 2019 Nov 14. doi: 10.1038/s41467-019-13033-4

Correction in:: Nat Commun. 2022; 13: 3066.

PMCID:: PMC6856192

Abstract Article PDF–2.2M

Select item 67942917.

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

Corinna Göppner, Ian J. Orozco, Maja B. Hoegg-Beiler, Audrey H. Soria, Christian A. Hübner, Fabio L. Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennaro, Thomas J. Jentsch

Nat Commun. 2019; 10: 4678. Published online 2019 Oct 15. doi: 10.1038/s41467-019-12113-9

PMCID:: PMC6794291

Abstract Article PDF–1.8M

Select item 66724518.

Leukoencephalopathy upon Disruption of the Chloride Channel ClC-2

Judith Blanz, Michaela Schweizer, Muriel Auberson, Hannes Maier, Adrian Muenscher, Christian A. Hübner, Thomas J. Jentsch

J Neurosci. 2007 Jun 13; 27(24): 6581–6589. doi: 10.1523/JNEUROSCI.0338-07.2007

PMCID:: PMC6672451

Abstract Article PDF–724K

Select item 66323079.

ClC-2 Voltage-Gated Channels Constitute Part of the Background Conductance and Assist Chloride Extrusion

Ilka Rinke, Judith Artmann, Valentin Stein

J Neurosci. 2010 Mar 31; 30(13): 4776–4786. doi: 10.1523/JNEUROSCI.6299-09.2010

PMCID:: PMC6632307

Abstract Article PDF–1.2M

Select item 633694510.

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

Younggeon Jin, Dina Ibrahim, Scott T. Magness, Anthony T. Blikslager

Am J Physiol Gastrointest Liver Physiol. 2018 Dec 1; 315(6): G966–G979. Published online 2018 Oct 4. doi: 10.1152/ajpgi.00087.2018

PMCID:: PMC6336945

Abstract Article

Select item 557866911.

Mouse models of human ocular disease for translational research

Mark P. Krebs, Gayle B. Collin, Wanda L. Hicks, Minzhong Yu, Jeremy R. Charette, Lan Ying Shi, Jieping Wang, Jürgen K. Naggert, Neal S. Peachey, Patsy M. Nishina

PLoS One. 2017; 12(8): e0183837. Published online 2017 Aug 31. doi: 10.1371/journal.pone.0183837

PMCID:: PMC5578669

Abstract Article PDF–26M

Select item 500753512.

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β

Yi-Jheng Peng, Jing-Jia Huang, Hao-Han Wu, Hsin-Ying Hsieh, Chia-Ying Wu, Shu-Ching Chen, Tsung-Yu Chen, Chih-Yung Tang

Sci Rep. 2016; 6: 32444. Published online 2016 Sep 1. doi: 10.1038/srep32444

PMCID:: PMC5007535

Abstract Article PDF–3.0M

Select item 457476413.

Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion

Meghali P. Nighot, Prashant K. Nighot, Thomas Y. Ma, Danuta H. Malinowska, Gary E. Shull, John Cuppoletti, Anthony T. Blikslager

PLoS One. 2015; 10(9): e0138174. Published online 2015 Sep 17. doi: 10.1371/journal.pone.0138174

PMCID:: PMC4574764

Abstract Article PDF–15M

Select item 437073614.

Ion Channel Expression in the Developing Enteric Nervous System

Caroline S. Hirst, Jaime P. P. Foong, Lincon A. Stamp, Emily Fegan, Stephan Dent, Edward C. Cooper, Alan E. Lomax, Colin R. Anderson, Joel C. Bornstein, Heather M. Young, Sonja J. McKeown

PLoS One. 2015; 10(3): e0123436. Published online 2015 Mar 23. doi: 10.1371/journal.pone.0123436

PMCID:: PMC4370736

Abstract Article PDF–9.5M

Select item 434313615.

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland

Marcelo A. Catalán, Yusuke Kondo, Gaspar Peña-Munzenmayer, Yasna Jaramillo, Frances Liu, Sooji Choi, Edward Crandall, Zea Borok, Per Flodby, Gary E. Shull, James E. Melvin

Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7): 2263–2268. Published online 2015 Feb 2. doi: 10.1073/pnas.1415739112

PMCID:: PMC4343136

Abstract Article PDF–1.2M

Select item 388011516.

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-Induced Murine Colitis

Prashant Nighot, Karen Young, Meghali Nighot, Manmeet Rawat, Eui J. Sung, Nitsan Maharshak, Scott E. Plevy, Thomas Ma, Anthony Blikslager

Inflamm Bowel Dis. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Inflamm Bowel Dis. 2013 Dec; 19(13): 10.1097/MIB.0b013e3182a82ae9. doi: 10.1097/MIB.0b013e3182a82ae9

PMCID:: PMC3880115

Abstract Article PDF–3.3M

Select item 360273917.

Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia

Eric S. Schiffhauer, Neeraj Vij, Olga Kovbasnjuk, Po Wei Kang, Doug Walker, Seakwoo Lee, Pamela L. Zeitlin

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1; 304(5): L324–L331. Published online 2013 Jan 11. doi: 10.1152/ajplung.00277.2012

PMCID:: PMC3602739

Abstract Article

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 347328219.

Sequential interaction of chloride and proton ions with the fast gate steer the voltage-dependent gating in ClC-2 chloride channels

Jorge E Sánchez-Rodríguez, José A De Santiago-Castillo, Juan Antonio Contreras-Vite, Pablo G Nieto-Delgado, Alejandra Castro-Chong, Jorge Arreola

J Physiol. 2012 Sep 1; 590(Pt 17): 4239–4253. Published online 2012 Jul 2. doi: 10.1113/jphysiol.2012.232660

PMCID:: PMC3473282

Abstract Article PDF–1.5M

Select item 333481920.

GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl⁻ Channel Auxiliary Subunit

Elena Jeworutzki, Tania López-Hernández, Xavier Capdevila-Nortes, Sònia Sirisi, Luiza Bengtsson, Marisol Montolio, Giovanni Zifarelli, Tanit Arnedo, Catrin S. Müller, Uwe Schulte, Virginia Nunes, Albert Martínez, Thomas J. Jentsch, Xavier Gasull, Michael Pusch, Raúl Estévez

Neuron. 2012 Mar 8; 73(5): 951–961. doi: 10.1016/j.neuron.2011.12.039