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Select item 110568431.

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3⁺ Regulatory T Cells

Yujian H. Yang, Roman Istomine, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Xiang Qun Shi, Tomoko Takano, Angela M. Thornton, Ethan M. Shevach, Ji Zhang, Ciriaco A. Piccirillo

Cell Rep. Author manuscript; available in PMC 2024 Apr 29.

Published in final edited form as: Cell Rep. 2020 Feb 4; 30(5): 1515–1529.e4. doi: 10.1016/j.celrep.2020.01.002

PMCID:: PMC11056843

Abstract Article PDF–2.6M

Select item 110080562.

SGK1 is essential for meiotic resumption in mammalian oocytes

Edgar del Llano, Rajan Iyyappan, Daria Aleshkina, Tomas Masek, Michal Dvoran, Zongliang Jiang, Martin Pospisek, Michal Kubelka, Andrej Susor

Eur J Cell Biol. Author manuscript; available in PMC 2024 Apr 11.

Published in final edited form as: Eur J Cell Biol. 2022 Apr; 101(2): 151210. Published online 2022 Feb 25. doi: 10.1016/j.ejcb.2022.151210

PMCID:: PMC11008056

Abstract Article PDF–945K

Select item 107976953.

SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis

Jianzhi Wu, Liping Gong, Yijie Li, Tiegang Liu, Rong Sun, Kexin Jia, Runping Liu, Fei Dong, Xiaohong Gu, Xiaojiaoyang Li

Int J Biol Sci. 2024; 20(3): 968–986. Published online 2024 Jan 12. doi: 10.7150/ijbs.90808

PMCID:: PMC10797695

Abstract Article PDF–14M

Select item 107171344.

EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex

Sharanpreet Hira, Balamuguran Packialakshmi, Xiaoming Zhou

J Physiol Sci. 2019 Sep; 69(5): 723–732. Published online 2019 Jun 8. doi: 10.1007/s12576-019-00687-4

PMCID:: PMC10717134

Abstract Article PDF–821K

Select item 102852695.

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang

Clin Transl Med. 2023 Jun; 13(6): e1308. Published online 2023 Jun 21. doi: 10.1002/ctm2.1308

PMCID:: PMC10285269

Abstract Article PDF–20M

Select item 100659856.

mTORC2 regulates CD8⁺ effector and memory T cell differentiation through serum and glucocorticoid kinase 1 (SGK1)

Chirag H. Patel, Emily B. Heikamp, Wei Xu, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Jiayu Wen, Ada J. Tam, Richard L. Blosser, Jonathan D. Powell

J Immunol. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: J Immunol. 2022 Dec 15; 209(12): 2287–2291. doi: 10.4049/jimmunol.2100669

PMCID:: PMC10065985

Abstract Article PDF–1.1M

Select item 99267127.

Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han, Liyong Pu

J Transl Med. 2023; 21: 121. Published online 2023 Feb 14. doi: 10.1186/s12967-023-03977-z

PMCID:: PMC9926712

Abstract Article PDF–12M

Select item 98805978.

Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation

Kiya W. Govek, Sixing Chen, Paraskevi Sgourdou, Yao Yao, Steven Woodhouse, Tingfang Chen, Marc V. Fuccillo, Douglas J. Epstein, Pablo G. Camara

Cell Rep. Author manuscript; available in PMC 2023 Jan 27.

Published in final edited form as: Cell Rep. 2022 Dec 6; 41(10): 111768. doi: 10.1016/j.celrep.2022.111768

PMCID:: PMC9880597

Abstract Article PDF–2.4M

Select item 93815049.

Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis

Junjun Jing, Jifan Feng, Yuan Yuan, Tingwei Guo, Jie Lei, Fei Pei, Thach-Vu Ho, Yang Chai

Nat Commun. 2022; 13: 4803. Published online 2022 Aug 16. doi: 10.1038/s41467-022-32490-y

PMCID:: PMC9381504

Abstract Article PDF–6.6M

Select item 930379310.

Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activated T cell nuclear factor transcription factor 2

Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf

IUBMB Life. 2022 May; 74(5): 463–473. Published online 2022 Feb 20. doi: 10.1002/iub.2605

PMCID:: PMC9303793

Abstract Article PDF–3.7M

Select item 919001811.

SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity

Xiao Han, Junling Ren, Hannah Lohner, Lan Yakoumatos, Ruqiang Liang, Huizhi Wang

J Biol Chem. 2022 Jun; 298(6): 102036. Published online 2022 May 17. doi: 10.1016/j.jbc.2022.102036

PMCID:: PMC9190018

Abstract Article PDF–4.0M

Select item 897358512.

Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression

Wei Chen, Haotian Zheng, Xuan Zhang, Yude Xu, Zhibin Fu, Xing Ji, Changhao Wei, Guoyao An, Mingyuan Tan, Mingwang Zhou

Bioengineered. 2022; 13(2): 4051–4062. Published online 2022 Feb 7. doi: 10.1080/21655979.2022.2032970

PMCID:: PMC8973585

Abstract Article PDF–2.7M

Select item 880558313.

Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy

Shujing Zhang, Yingchao Wang, Min Yu, Ye Shang, Yanxu Chang, Hong Zhao, Yu Kang, Lu Zhao, Lei Xu, Xiaoping Zhao, Dario Difrancesco, Mirko Baruscotti, Yi Wang

Adv Sci (Weinh) 2022 Jan; 9(2): 2101485. Published online 2021 Nov 10. doi: 10.1002/advs.202101485