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Select item 111788421.

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Sci Rep. 2024; 14: 13727. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64608-1

PMCID:: PMC11178842

Abstract Article PDF–5.4M

Select item 108809612.

The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice

Wenqiang Sun, Xiaohui Liu, Laichun Song, Liang Tao, Kaisheng Lai, Hui Jiang, Hongyan Xiao

PLoS One. 2024; 19(2): e0296802. Published online 2024 Feb 21. doi: 10.1371/journal.pone.0296802

PMCID:: PMC10880961

Abstract Article PDF–3.1M

Select item 106867653.

Aberrant Differentiation of Second Heart Field Mesoderm Prefigures Cellular Defects in the Outflow Tract in Response to Loss of FGF8

Sophie Astrof, Cecilia Arriagada, Yukio Saijoh, Alexandre Francou, Robert G. Kelly, Anne Moon

Dev Biol. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Dev Biol. 2023 Jul; 499: 10–21. Published online 2023 Apr 14. doi: 10.1016/j.ydbio.2023.04.001

PMCID:: PMC10686765

Abstract Article PDF–2.2M

Select item 103359374.

Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis

Abhishek Sampath Kumar, Luyi Tian, Adriano Bolondi, Amèlia Aragonés Hernández, Robert Stickels, Helene Kretzmer, Evan Murray, Lars Wittler, Maria Walther, Gabriel Barakat, Leah Haut, Yechiel Elkabetz, Evan Z. Macosko, Léo Guignard, Fei Chen, Alexander Meissner

Nat Genet. 2023; 55(7): 1176–1185. Published online 2023 Jul 6. doi: 10.1038/s41588-023-01435-6

PMCID:: PMC10335937

Abstract Article PDF–25M

Select item 100013725.

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2

Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich

Cells. 2023 Mar; 12(5): 721. Published online 2023 Feb 24. doi: 10.3390/cells12050721

PMCID:: PMC10001372

Abstract Article PDF–2.7M

Select item 98603316.

Titin force in muscle cells alters lattice order, thick and thin filament protein formation

Anthony L. Hessel, Weikang Ma, Nicole Mazara, Paige E. Rice, Devin Nissen, Henry Gong, Michel Kuehn, Thomas Irving, Wolfgang A. Linke

Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48): e2209441119. Published online 2022 Nov 21. doi: 10.1073/pnas.2209441119

PMCID:: PMC9860331

Abstract Article PDF–2.9M

Select item 97797517.

Rbm20^ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness

Marloes van den Berg, Eva L. Peters, Robbert J. van der Pijl, Shengyi Shen, Leo M. A. Heunks, Henk L. Granzier, Coen A. C. Ottenheijm

Int J Mol Sci. 2022 Dec; 23(24): 15689. Published online 2022 Dec 10. doi: 10.3390/ijms232415689

PMCID:: PMC9779751

Abstract Article PDF–3.2M

Select item 95502168.

Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions

Colleen Kelly, Nicola Pace, Matthew Gage, Mark Pfuhl

J Mol Biol. Author manuscript; available in PMC 2022 Oct 10.

Published in final edited form as: J Mol Biol. 2021 Jun 25; 433(13): 166977. Published online 2021 Mar 31. doi: 10.1016/j.jmb.2021.166977

PMCID:: PMC9550216

Abstract Article PDF–1.1M

Select item 94822859.

Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice

Pabodha Hettige, Uzma Tahir, Kiisa C. Nishikawa, Matthew J. Gage

BMC Genomics. 2022; 23: 657. Published online 2022 Sep 17. doi: 10.1186/s12864-022-08873-2

PMCID:: PMC9482285

Abstract Article PDF–6.5M

Select item 928767110.

Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments

Zhentao Zhang, Wenhui Zhang, Robert Blakes, Lauren J. Sundby, Zengdun Shi, Don C. Rockey, James M. Ervasti, Young-Jae Nam

Stem Cell Reports. 2022 Jul 12; 17(7): 1604–1619. Published online 2022 Jun 9. doi: 10.1016/j.stemcr.2022.05.004

PMCID:: PMC9287671

Abstract Article PDF–9.8M

Select item 894069011.

Shortening the thick filament by partial deletion of titin’s C-zone alters cardiac function by reducing the operating sarcomere length range

Mei Methawasin, Gerrie P. Farman, Shawtaroh Granzier-Nakajima, Joshua Strom, Balazs Kiss, John E Smith, III, Henk Granzier

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2022 Apr; 165: 103–114. Published online 2022 Jan 11. doi: 10.1016/j.yjmcc.2022.01.002

PMCID:: PMC8940690

Abstract Article PDF–2.0M

Select item 864269212.

Depletion of m⁶A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin

Siyun Gao, Haifeng Sun, Kejing Chen, Xueying Gu, Hongyu Chen, Liudan Jiang, Lei Chen, Shengqi Zhang, Yi Liu, Dan Shi, Dandan Liang, Liang Xu, Jian Yang, Yanjiao Ruan, Hao Chen, Bin Shen, Honghui Ma, Yi‐Han Chen

J Cell Mol Med. 2021 Dec; 25(23): 10879–10891. Published online 2021 Oct 30. doi: 10.1111/jcmm.16955

PMCID:: PMC8642692

Abstract Article PDF–1.8M

Select item 846600413.

Titin M-line insertion sequence 7 is required for proper cardiac function in mice

Ariane Biquand, Simone Spinozzi, Paola Tonino, Jérémie Cosette, Joshua Strom, Zaher Elbeck, Ralph Knöll, Henk Granzier, William Lostal, Isabelle Richard

J Cell Sci. 2021 Sep 15; 134(18): jcs258684. Published online 2021 Sep 17. doi: 10.1242/jcs.258684

PMCID:: PMC8466004

Abstract Article

Select item 803932214.

Non-cross Bridge Viscoelastic Elements Contribute to Muscle Force and Work During Stretch-Shortening Cycles: Evidence From Whole Muscles and Permeabilized Fibers

Anthony L. Hessel, Jenna A. Monroy, Kiisa C. Nishikawa

Front Physiol. 2021; 12: 648019. Published online 2021 Mar 29. doi: 10.3389/fphys.2021.648019

PMCID:: PMC8039322

Abstract Article PDF–3.7M

Select item 791023715.

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant

He Jiang, Charlotte Hooper, Matthew Kelly, Violetta Steeples, Jillian N. Simon, Julia Beglov, Amar J. Azad, Lisa Leinhos, Pauline Bennett, Elisabeth Ehler, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Roman Fischer, Raphael Heilig, Henrik Isackson, Mehroz Ehsan, Giannino Patone, Norbert Huebner, Benjamin Davies, Hugh Watkins, Katja Gehmlich

Basic Res Cardiol. 2021; 116(1): 14. Published online 2021 Feb 26. doi: 10.1007/s00395-021-00853-z

PMCID:: PMC7910237

Abstract Article PDF–1.7M

Select item 778258916.

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

Xinyun Chen, Ying Liu, Chen Xu, Lina Ba, Zhuo Liu, Xiuya Li, Jie Huang, Ed Simpson, Hongyu Gao, Dayan Cao, Wei Sheng, Hanping Qi, Hongrui Ji, Maria Sanderson, Chen-Leng Cai, Xiaohui Li, Lei Yang, Jie Na, Kenichi Yamamura, Yunlong Liu, Guoying Huang, Weinian Shou, Ning Sun

Nat Commun. 2021; 12: 89. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20327-5

PMCID:: PMC7782589

Abstract Article PDF–8.6M

Select item 778159417.

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

Yong Li, Anthony L Hessel, Andreas Unger, David Ing, Jannik Recker, Franziska Koser, Johanna K Freundt, Wolfgang A Linke

eLife. 2020; 9: e64107. Published online 2020 Dec 24. doi: 10.7554/eLife.64107

PMCID:: PMC7781594

Abstract Article PDF–7.1M

Select item 771001618.

Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration

Ivana Prokic, Belinda S. Cowling, Candice Kutchukian, Christine Kretz, Hichem Tasfaout, Vincent Gache, Josiane Hergueux, Olivia Wendling, Arnaud Ferry, Anne Toussaint, Christos Gavriilidis, Vasugi Nattarayan, Catherine Koch, Jeanne Lainé, Roy Combe, Laurent Tiret, Vincent Jacquemond, Fanny Pilot-Storck, Jocelyn Laporte

Dis Model Mech. 2020 Nov 1; 13(11): dmm044354. Published online 2020 Nov 24. doi: 10.1242/dmm.044354

PMCID:: PMC7710016

Abstract Article

Select item 761535919.

Characterization of a common progenitor pool of the epicardium and myocardium

Richard C.V. Tyser, Ximena Ibarra-Soria, Katie McDole, Satish A. Jayaram, Jonathan Godwin, Teun A.H. van den Brand, Antonio M.A. Miranda, Antonio Scialdone, Philipp J. Keller, John C. Marioni, Shankar Srinivas

Science. Author manuscript; available in PMC 2023 Dec 18.

Published in final edited form as: Science. 2021 Mar 5; 371(6533): eabb2986. Published online 2021 Jan 7. doi: 10.1126/science.abb2986

PMCID:: PMC7615359

Abstract Article PDF–3.9M

Select item 753387820.

Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)

Christine M. Loescher, Martin Breitkreuz, Yong Li, Alexander Nickel, Andreas Unger, Alexander Dietl, Andreas Schmidt, Belal A. Mohamed, Sebastian Kötter, Joachim P. Schmitt, Marcus Krüger, Martina Krüger, Karl Toischer, Christoph Maack, Lars I. Leichert, Nazha Hamdani, Wolfgang A. Linke

Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24545–24556. Published online 2020 Sep 14. doi: 10.1073/pnas.2004900117

PMCID:: PMC7533878

Abstract Article PDF–2.3M

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