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Items: 1 to 20 of 146

1.
Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity
Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He
Cell Commun Signal. 2024; 22: 287. Published online 2024 May 27. doi: 10.1186/s12964-024-01670-2
PMCID:
PMC11129409
AbstractArticlePDF–2.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Generating a murine PTEN null cell line to discover the key role of p110β-PAK1 in Castration-Resistant Prostate Cancer invasion
Haizhen Wang, Yu Zhou, Chen Chu, Jialing Xiao, Shanshan Zheng, Manav Korpal, Joshua M Korn, Tiffany Penaloza, Richard R. Drake, Wenjian Gan, Xueliang Gao
Mol Cancer Res. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: Mol Cancer Res. 2023 Dec 1; 21(12): 1317–1328. doi: 10.1158/1541-7786.MCR-22-0808
PMCID:
PMC10841189
AbstractArticlePDF–1.6M
4.
The Role of P21-Activated Kinase (Pak1) in Sinus Node Function
Carlos H. Pereira, Dan J. Bare, Paola C. Rosas, Fernando A.L. Dias, Kathrin Banach
J Mol Cell Cardiol. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2023 Jun; 179: 90–101. Published online 2023 Apr 20. doi: 10.1016/j.yjmcc.2023.04.004
PMCID:
PMC10294268
AbstractArticlePDF–1.4M
5.
Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge
Eunjeong Jung, Rebecca Capel, Congshan Jiang, Elisa Venturi, Georgiana Neagu, Sarah Pearcey, Yafei Zhou, Yanmin Zhang, Ming Lei
Philos Trans R Soc Lond B Biol Sci. June 19, 2023; 378(1879): 20220168. Published online May 01, 2023. doi: 10.1098/rstb.2022.0168
Correction in:
Philos Trans R Soc Lond B Biol Sci. July 17, 2023; 378(1881): 20230143.
PMCID:
PMC10150202
AbstractArticlePDF–1.2M
6.
Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Cell Death Dis. 2023 Jan; 14(1): 52. Published online 2023 Jan 21. doi: 10.1038/s41419-022-05442-z
PMCID:
PMC9867761
AbstractArticlePDF–10M
7.
Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)
Suneet Mehrotra, Marsha L. Pierce, Shashank M. Dravid, Thomas F. Murray
Mar Drugs. 2022 Sep; 20(9): 559. Published online 2022 Aug 31. doi: 10.3390/md20090559
PMCID:
PMC9504648
AbstractArticlePDF–4.8M
8.
Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis
Karla E. Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Jinhee Hwang, Supriyo Bhattacharya, Erika M. McCown, Pablo A. Garcia, Chunxue Zhou, Eunjin Oh, Stephanie M. Yoder, Jeffrey S. Elmendorf, Debbie C. Thurmond
Front Endocrinol (Lausanne) 2022; 13: 821849. Published online 2022 Feb 11. doi: 10.3389/fendo.2022.821849
PMCID:
PMC8881144
AbstractArticlePDF–7.7M
9.
Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice
Anna Longatti, Luisa Ponzoni, Edoardo Moretto, Giorgia Giansante, Norma Lattuada, Maria Nicol Colombo, Maura Francolini, Mariaelvina Sala, Luca Murru, Maria Passafaro
Mol Neurobiol. 2021; 58(12): 6092–6110. Published online 2021 Aug 28. doi: 10.1007/s12035-021-02502-x
PMCID:
PMC8639580
AbstractArticlePDF–2.8M
10.
PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression
Wen-Lin Cheng, Quan Zhang, Bo Li, Jian-Lei Cao, Lin Jiao, Sheng-Ping Chao, Zhibing Lu, Fang Zhao
Oxid Med Cell Longev. 2021; 2021: 6957900. Published online 2021 Sep 23. doi: 10.1155/2021/6957900
PMCID:
PMC8483905
AbstractArticlePDF–2.1M
11.
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)
Eric Hawley, Jeffrey Gehlhausen, Sofiia Karchugina, Hoi-Yee Chow, Daniela Araiza-Olivera, Maria Radu, Abbi Smith, Ciersten Burks, Li Jiang, Xiaohong Li, Waylan Bessler, Andrea Masters, Donna Edwards, Callie Burgin, David Jones, Charles Yates, D Wade Clapp, Jonathan Chernoff, Su-Jung Park
Hum Mol Genet. 2021 Sep 1; 30(17): 1607–1617. Published online 2021 Jun 1. doi: 10.1093/hmg/ddab106
PMCID:
PMC8369838
AbstractArticlePDF–1.6M
12.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
13.
A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis
Miwon Ahn, Eunjin Oh, Erika M. McCown, Xin Wang, Rajakrishnan Veluthakal, Debbie C. Thurmond
Metabolism. Author manuscript; available in PMC 2021 May 15.
Published in final edited form as: Metabolism. 2021 Feb; 115: 154431. Published online 2020 Nov 10. doi: 10.1016/j.metabol.2020.154431
PMCID:
PMC8123936
AbstractArticlePDF–4.2M
14.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
15.
Deletion of P21 Activated Kinase-1 Induces Age-dependent Increased Visceral Adiposity and Cardiac Dysfunction in Female Mice
Ashley Batra, Chad M. Warren, Yunbo Ke, Maximilian McCann, Monika Halas, Andrielle E. Capote, Chong Wee Liew, R. John Solaro, Paola C. Rosas
Mol Cell Biochem. Author manuscript; available in PMC 2022 Mar 1.
Published in final edited form as: Mol Cell Biochem. 2021 Mar; 476(3): 1337–1349. Published online 2021 Jan 3. doi: 10.1007/s11010-020-03993-3
PMCID:
PMC7925422
AbstractArticlePDF–1.9M
16.
A Novel PAK1–Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation
Adrian Frick, Vineeta Khare, Kristine Jimenez, Kyle Dammann, Michaela Lang, Anita Krnjic, Christina Gmainer, Maximilian Baumgartner, Ildiko Mesteri, Christoph Gasche
Cell Mol Gastroenterol Hepatol. 2021; 11(3): 892–907.e1. Published online 2020 Nov 12. doi: 10.1016/j.jcmgh.2020.11.001
PMCID:
PMC7900837
AbstractArticlePDF–6.2M
17.
Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways
Jae-Hong Kim, Yeojin Seo, Myungjin Jo, Hyejin Jeon, Young-Seop Kim, Eun-Jung Kim, Donggun Seo, Won-Ha Lee, Sang Ryong Kim, Nozomu Yachie, Quan Zhong, Marc Vidal, Frederick P. Roth, Kyoungho Suk
J Biol Chem. 2020 Dec 11; 295(50): 16906–16919. Published online 2020 Oct 15. doi: 10.1074/jbc.RA120.014831
PMCID:
PMC7863907
AbstractArticlePDF–3.4M
18.
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
Mol Brain. 2021; 14: 21. Published online 2021 Jan 22. doi: 10.1186/s13041-021-00735-4
PMCID:
PMC7821731
AbstractArticlePDF–2.8M
19.
P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection
Hao Chang, Kai‐Yue He, Chen Li, Yang‐Yue Ni, Mai‐Ning Li, Lin Chen, Min Hou, Zikai Zhou, Zhi‐Peng Xu, Min‐Jun Ji
J Cell Mol Med. 2020 Dec; 24(24): 14325–14338. Published online 2020 Oct 30. doi: 10.1111/jcmm.16050
PMCID:
PMC7753984
AbstractArticlePDF–2.0M
20.
PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension
Juliette van Dijk, Guillaume Bompard, Gabriel Rabeharivelo, Julien Cau, Claude Delsert, Nathalie Morin
Int J Mol Sci. 2020 Oct; 21(20): 7531. Published online 2020 Oct 13. doi: 10.3390/ijms21207531
PMCID:
PMC7589885
AbstractArticlePDF–4.3M

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