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Items: 1 to 20 of 92

1.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
2.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
3.
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188
PMCID:
PMC9881136
AbstractArticlePDF–4.4M
4.
Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer
Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz
Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7
PMCID:
PMC9290241
AbstractArticlePDF–8.2M
5.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
6.
The DNA endonuclease Mus81 regulates ZEB1 expression and serves as a target of BET4 inhibitors in gastric cancer
Yuping Yin, Weizhen Liu, Qian Shen, Peng Zhang, Lulu Wang, Ruikang Tao, Hang Li, Xianxiong Ma, Xiangyu Zeng, Jae-Ho Cheong, Shumei Song, Jaffer A. Ajani, Gordon B. Mills, Kaixiong Tao, Guang Peng
Mol Cancer Ther. Author manuscript; available in PMC 2021 Aug 6.
Published in final edited form as: Mol Cancer Ther. 2019 Aug; 18(8): 1439–1450. Published online 2019 May 29. doi: 10.1158/1535-7163.MCT-18-0833
PMCID:
PMC8345820
AbstractArticlePDF–5.2M
7.
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
Xiao Wu, Bin Wang
Nat Commun. 2021; 12: 4373. Published online 2021 Jul 16. doi: 10.1038/s41467-021-24665-w
PMCID:
PMC8285526
AbstractArticlePDF–3.6M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
10.
ATRX and RECQ5 define distinct homologous recombination subpathways
Amira Elbakry, Szilvia Juhász, Ki Choi Chan, Markus Löbrich
Proc Natl Acad Sci U S A. 2021 Jan 19; 118(3): e2010370118. Published online 2021 Jan 11. doi: 10.1073/pnas.2010370118
PMCID:
PMC7826375
AbstractArticlePDF–1.7M
11.
Mus81-Eme1–dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity
Nicolás Luis Calzetta, Marina Alejandra González Besteiro, Vanesa Gottifredi
Sci Adv. 2020 Dec; 6(50): eabc8257. Published online 2020 Dec 9. doi: 10.1126/sciadv.abc8257
PMCID:
PMC7725468
AbstractArticlePDF–4.9M
12.
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
Benjamin Pardo, María Moriel‐Carretero, Thibaud Vicat, Andrés Aguilera, Philippe Pasero
EMBO Rep. 2020 Jul 3; 21(7): e49367. Published online 2020 May 17. doi: 10.15252/embr.201949367
PMCID:
PMC7332989
AbstractArticlePDF–2.6M
13.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair
Huimin Zhang, Zhen Chen, Yin Ye, Zu Ye, Dan Cao, Yun Xiong, Mrinal Srivastava, Xu Feng, Mengfan Tang, Chao Wang, John A Tainer, Junjie Chen
Nucleic Acids Res. 2019 Nov 4; 47(19): 10181–10201. Published online 2019 Sep 9. doi: 10.1093/nar/gkz769
PMCID:
PMC6821277
AbstractArticlePDF–3.8M
16.
RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease
Francesca Antonella Aiello, Anita Palma, Eva Malacaria, Li Zheng, Judith L Campbell, Binghui Shen, Annapaola Franchitto, Pietro Pichierri
Nucleic Acids Res. 2019 Jul 26; 47(13): 6796–6810. Published online 2019 May 22. doi: 10.1093/nar/gkz431
PMCID:
PMC6648349
AbstractArticlePDF–9.3M
17.
H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids
Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker, Benjamin M. Foster, Nhuong V. Nguyen, Tracey Beyer, Laura C. Cesa, Peter A. Faull, Saulius Lukauskas, Thomas Frimurer, J. Ross Chapman, Till Bartke, Anja Groth
Nat Cell Biol. Author manuscript; available in PMC 2019 Aug 25.
Published in final edited form as: Nat Cell Biol. 2019 Mar; 21(3): 311–318. Published online 2019 Feb 25. doi: 10.1038/s41556-019-0282-9
PMCID:
PMC6420097
ArticlePDF–1.7M
18.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders
Siwei Chen, Robert Fragoza, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder, Bernie Devlin, Haiyuan Yu
Nat Genet. Author manuscript; available in PMC 2019 Jul 1.
Published in final edited form as: Nat Genet. 2018 Jul; 50(7): 1032–1040. Published online 2018 Jun 11. doi: 10.1038/s41588-018-0130-z
PMCID:
PMC6314957
AbstractArticlePDF–1.3M
19.
Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress
Anita Palma, Giusj Monia Pugliese, Ivana Murfuni, Veronica Marabitti, Eva Malacaria, Sara Rinalducci, Anna Minoprio, Massimo Sanchez, Filomena Mazzei, Lello Zolla, Annapaola Franchitto, Pietro Pichierri
Nucleic Acids Res. 2018 Jun 1; 46(10): 5109–5124. Published online 2018 Apr 18. doi: 10.1093/nar/gky280
PMCID:
PMC6007509
AbstractArticlePDF–3.6M
20.
Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma
T. P. MacGregor, R. Carter, R. S. Gillies, J. M. Findlay, C. Kartsonaki, F. Castro-Giner, N. Sahgal, L. M. Wang, R. Chetty, N. D. Maynard, J. B. Cazier, F. Buffa, P. J. McHugh, I. Tomlinson, M. R. Middleton, R. A. Sharma
Sci Rep. 2018; 8: 7265. Published online 2018 May 8. doi: 10.1038/s41598-018-24232-2
PMCID:
PMC5940885
AbstractArticlePDF–1.3M

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