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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 88570492.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78410004.

Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells

Hai-tao Geng, Rui-juan Cao, Lei Cheng, Chun-yuan Liu

Oncol Res. 2017; 25(7): 1039–1046. Published online 2017 Aug 7. doi: 10.3727/096504016X14813914187138

PMCID:: PMC7841000

Abstract Article PDF–5.7M

Select item 77825445.

Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM

Ting Li, Nanjing Liu, Yingying Gao, Zhen Quan, Yanni Hao, Chaowen Yu, Luo Li, Mengjuan Yuan, Lingfang Niu, Chunli Luo, Xiaohou Wu

Br J Cancer. 2021 Jan 5; 124(1): 247–258. Published online 2020 Oct 7. doi: 10.1038/s41416-020-01091-1

PMCID:: PMC7782544

Abstract Article PDF–3.2M

Select item 72066536.

Structural basis for the dominant or recessive character of GLIALCAM mutations found in leukodystrophies

Xabier Elorza-Vidal, Efren Xicoy-Espaulella, Adrià Pla-Casillanis, Marta Alonso-Gardón, Héctor Gaitán-Peñas, Carolyn Engel-Pizcueta, Juan Fernández-Recio, Raúl Estévez

Hum Mol Genet. 2020 May 8; 29(7): 1107–1120. Published online 2020 Jan 21. doi: 10.1093/hmg/ddaa009

PMCID:: PMC7206653

Abstract Article PDF–1.9M

Select item 67855957.

Identification in Chinese patients with GLIALCAM mutations of megalencephalic leukoencephalopathy with subcortical cysts and brain pathological study on Glialcam knock-in mouse models

Zhen Shi, Hui-Fang Yan, Bin-Bin Cao, Mang-Mang Guo, Han Xie, Kai Gao, Jiang-Xi Xiao, Yan-Ling Yang, Hui Xiong, Qiang Gu, Ming Li, Ye Wu, Yu-Wu Jiang, Jing-Min Wang

World J Pediatr. 2019; 15(5): 454–464. Published online 2019 Aug 1. doi: 10.1007/s12519-019-00284-w

PMCID:: PMC6785595

Abstract Article PDF–3.9M

Select item 67781378.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 63900619.

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain

Qingfu Deng, Li Luo, Zhen Quan, Nanjing Liu, Zhongbo Du, Wei Sun, Chunli Luo, Xiaohou Wu

Mol Med Rep. 2019 Mar; 19(3): 2115–2124. Published online 2019 Jan 10. doi: 10.3892/mmr.2019.9841

Correction in:: Mol Med Rep. 2022 Jul; 26(1): 230.

PMCID:: PMC6390061

Abstract Article PDF–2.1M

Select item 595870610.

HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro

Zhongbo Du, Luo Li, Wei Sun, Xiao Wang, Yao Zhang, Zhixiong Chen, Mengjuan Yuan, Zhen Quan, Nanjing Liu, Yanni Hao, Ting Li, Jinhua Wang, Chunli Luo, Xiaohou Wu

Int J Oncol. 2018 Jul; 53(1): 99–112. Published online 2018 Apr 12. doi: 10.3892/ijo.2018.4370

PMCID:: PMC5958706

Abstract Article PDF–1.8M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 509815312.

HepaCAM associates with connexin 43 and enhances its localization in cellular junctions

Meihui Wu, Mei Chung Moh, Herbert Schwarz

Sci Rep. 2016; 6: 36218. Published online 2016 Nov 7. doi: 10.1038/srep36218

PMCID:: PMC5098153

Abstract Article PDF–1.0M

Select item 491395113.

Ten Novel Mutations in Chinese Patients with Megalencephalic Leukoencephalopathy with Subcortical Cysts and a Long-Term Follow-Up Research

Binbin Cao, Huifang Yan, Mangmang Guo, Han Xie, Ye Wu, Qiang Gu, Jiangxi Xiao, Jing Shang, Yanling Yang, Hui Xiong, Zhengping Niu, Xiru Wu, Yuwu Jiang, Jingmin Wang

PLoS One. 2016; 11(6): e0157258. Published online 2016 Jun 20. doi: 10.1371/journal.pone.0157258

PMCID:: PMC4913951

Abstract Article PDF–3.4M

Select item 459429114.

Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy

Xavier Capdevila-Nortes, Elena Jeworutzki, Xabier Elorza-Vidal, Alejandro Barrallo-Gimeno, Michael Pusch, Raúl Estévez

J Physiol. 2015 Sep 15; 593(Pt 18): 4165–4180. Published online 2015 Jun 23. doi: 10.1113/JP270467

PMCID:: PMC4594291

Abstract Article PDF–2.9M

Select item 415667915.

GlialCAM, a CLC-2 Cl^- Channel Subunit, Activates the Slow Gate of CLC Chloride Channels

Elena Jeworutzki, Laura Lagostena, Xabier Elorza-Vidal, Tania López-Hernández, Raúl Estévez, Michael Pusch

Biophys J. 2014 Sep 2; 107(5): 1105–1116. Published online 2014 Sep 2. doi: 10.1016/j.bpj.2014.07.040

PMCID:: PMC4156679

Abstract Article PDF–3.9M

Select item 394156816.

Autism-epilepsy phenotype with macrocephaly suggests PTEN, but not GLIALCAM, genetic screening

Maria Marchese, Valerio Conti, Giulia Valvo, Francesca Moro, Filippo Muratori, Raffaella Tancredi, Filippo M Santorelli, Renzo Guerrini, Federico Sicca

BMC Med Genet. 2014; 15: 26. Published online 2014 Feb 27. doi: 10.1186/1471-2350-15-26

PMCID:: PMC3941568

Abstract Article PDF–780K

Select item 385637617.

Identification of Hypermethylation in Hepatocyte Cell Adhesion Molecule Gene Promoter Region in Bladder Carcinoma

Jia Tao, Qi Liu, Xiaohou Wu, Xin Xu, Yanyi Zhang, Qiuju Wang, Chunli Luo

Int J Med Sci. 2013; 10(13): 1860–1867. Published online 2013 Nov 11. doi: 10.7150/ijms.6460

PMCID:: PMC3856376

Abstract Article PDF–1.4M

Select item 333481918.

GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl⁻ Channel Auxiliary Subunit

Elena Jeworutzki, Tania López-Hernández, Xavier Capdevila-Nortes, Sònia Sirisi, Luiza Bengtsson, Marisol Montolio, Giovanni Zifarelli, Tanit Arnedo, Catrin S. Müller, Uwe Schulte, Virginia Nunes, Albert Martínez, Thomas J. Jentsch, Xavier Gasull, Michael Pusch, Raúl Estévez

Neuron. 2012 Mar 8; 73(5): 951–961. doi: 10.1016/j.neuron.2011.12.039

PMCID:: PMC3334819

Abstract Article

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 307190920.

Mutant GlialCAM Causes Megalencephalic Leukoencephalopathy with Subcortical Cysts, Benign Familial Macrocephaly, and Macrocephaly with Retardation and Autism

Tania López-Hernández, Margreet C. Ridder, Marisol Montolio, Xavier Capdevila-Nortes, Emiel Polder, Sònia Sirisi, Anna Duarri, Uwe Schulte, Bernd Fakler, Virginia Nunes, Gert C. Scheper, Albert Martínez, Raúl Estévez, Marjo S. van der Knaap

Am J Hum Genet. 2011 Apr 8; 88(4): 422–432. doi: 10.1016/j.ajhg.2011.02.009

PMCID:: PMC3071909

Abstract Article PDF–1.3M

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