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Select item 116124501.

The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer’s disease

Wandi Xiong, Kaiyu Xu, Jacquelyne Ka-Li Sun, Siling Liu, Baizhen Zhao, Jie Shi, Karl Herrup, Hei-Man Chow, Lin Lu, Jiali Li

EMBO J. 2024 Dec; 43(23): 6001–6031. Published online 2024 Oct 18. doi: 10.1038/s44318-024-00270-7

PMCID:: PMC11612450

Abstract Article PDF–10M

Select item 115552612.

Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice

Yi Guo, Chuanbin Cai, Bingjie Zhang, Bo Tan, Qinmin Tang, Zhifeng Lei, Xiaolan Qi, Jiang Chen, Xiaojiang Zheng, Dan Zi, Song Li, Jun Tan

EMBO Mol Med. 2024 Nov; 16(11): 2856–2881. Published online 2024 Oct 11. doi: 10.1038/s44321-024-00146-7

PMCID:: PMC11555261

Abstract Article PDF–5.9M

Select item 115504853.

TRIM11 protects against tauopathies and is downregulated in Alzheimer’s disease

Zi-Yang Zhang, Dilshan S. Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Y. Zhao, Thomas P. McMonagle, Guixin Zhu, Kenzo D. Lacuarta, Jianing Song, John Q. Trojanowski, Hong Xu, Virginia M.-Y. Lee, Xiaolu Yang

Science. Author manuscript; available in PMC 2024 Nov 10.

Published in final edited form as: Science. 2023 Jul 28; 381(6656): eadd6696. Published online 2023 Jul 28. doi: 10.1126/science.add6696

PMCID:: PMC11550485

Abstract Article PDF–3.4M

Select item 115492184.

VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction

Harris E. Blankenship, Kelsey A. Carter, Kevin D. Pham, Nina T. Cassidy, Andrea N. Markiewicz, Michael I. Thellmann, Amanda L. Sharpe, Willard M. Freeman, Michael J. Beckstead

Nat Commun. 2024; 15: 9673. Published online 2024 Nov 8. doi: 10.1038/s41467-024-53891-1

PMCID:: PMC11549218

Abstract Article PDF–3.5M

Select item 114762585.

The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice

Zhe Zhao, Xingqing Wu, Weijia Wu, Yingzhe Tang, Xiangyuan Meng, Mei Peng, Changfa Tang, Lan Zheng, Wenfeng Liu

Int J Mol Sci. 2024 Oct; 25(19): 10244. Published online 2024 Sep 24. doi: 10.3390/ijms251910244

PMCID:: PMC11476258

Abstract Article PDF–12M

Select item 114712336.

Differential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia

Xiao-Yue Hong, Siwei Li, Tian Li, Wei Chen, Yirong Li, Zhuo Wang, Yi Luo

Heliyon. 2024 Oct 15; 10(19): e38843. Published online 2024 Oct 2. doi: 10.1016/j.heliyon.2024.e38843

PMCID:: PMC11471233

Abstract Article PDF–6.7M

Select item 114416297.

M. Windy McNerney, Eric P. Kraybill, Sindhu Narayanan, Fatemeh S. Mojabi, Vaibhavi Venkataramanan, Alesha Heath

Exp Gerontol. Author manuscript; available in PMC 2024 Sep 30.

Published in final edited form as: Exp Gerontol. 2023 Nov; 183: 112323. Published online 2023 Nov 1. doi: 10.1016/j.exger.2023.112323

PMCID:: PMC11441629

Abstract Article PDF–965K

Select item 114154178.

Relationship Between Reactive Astrocytes, by [¹⁸F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease

Yanyan Kong, Cinzia A. Maschio, Xuefeng Shi, Fang Xie, Chuantao Zuo, Uwe Konietzko, Kuangyu Shi, Axel Rominger, Jianfei Xiao, Qi Huang, Roger M. Nitsch, Yihui Guan, Ruiqing Ni

Mol Neurobiol. 2024; 61(10): 8387–8401. Published online 2024 Mar 19. doi: 10.1007/s12035-024-04106-7

PMCID:: PMC11415417

Abstract Article PDF–8.3M

Select item 113925319.

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

Felix Michaud, Ruggiero Francavilla, Dimitry Topolnik, Parisa Iloun, Suhel Tamboli, Frederic Calon, Lisa Topolnik

eLife. 2024; 13: RP95412. Published online 2024 Sep 12. doi: 10.7554/eLife.95412

PMCID:: PMC11392531

Abstract Article PDF–3.7M

Select item 1137326110.

Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD

Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

Stem Cell Res Ther. 2024; 15: 275. Published online 2024 Sep 3. doi: 10.1186/s13287-024-03805-1

PMCID:: PMC11373261

Abstract Article PDF–13M

Select item 1134831011.

Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ

Kuo Yan, Chen Zhang, Jongkyun Kang, Paola Montenegro, Jie Shen

Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34): e2409343121. Published online 2024 Aug 13. doi: 10.1073/pnas.2409343121

PMCID:: PMC11348310

Abstract Article PDF–3.3M

Select item 1134654112.

Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice

Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve

Gut Microbes. 2024; 16(1): 2389319. Published online 2024 Aug 25. doi: 10.1080/19490976.2024.2389319

PMCID:: PMC11346541

Abstract Article PDF–5.8M

Select item 1131978613.

Multiple Transcriptomic Analyses Explore Potential Synaptic Biomarker Rabphilin-3A for Alzheimer's Disease

Doan Phuong Quy Nguyen, Son Pham, Amadou Wurry Jallow, Nguyen-Tuong Ho, Bao Le, Hung Tran Quang, Yi-Fang Lin, Yung-Feng Lin

Sci Rep. 2024; 14: 18717. Published online 2024 Aug 12. doi: 10.1038/s41598-024-66693-8

PMCID:: PMC11319786

Abstract Article PDF–6.8M

Select item 1126141614.

The role of m6A modification in the risk prediction and Notch1 pathway of Alzheimer’s disease

Yingdan Qiao, Yingna Mei, Minqi Xia, Deng Luo, Ling Gao

iScience. 2024 Jul 19; 27(7): 110235. Published online 2024 Jun 8. doi: 10.1016/j.isci.2024.110235

PMCID:: PMC11261416

Abstract Article PDF–8.3M

Select item 1124121715.

Prodromic Inflammatory–Oxidative Stress in Peritoneal Leukocytes of Triple-Transgenic Mice for Alzheimer’s Disease

Noemí Ceprián, Irene Martínez de Toda, Ianire Maté, Antonio Garrido, Lydia Gimenez-Llort, Mónica De la Fuente

Int J Mol Sci. 2024 Jul; 25(13): 6976. Published online 2024 Jun 26. doi: 10.3390/ijms25136976

PMCID:: PMC11241217

Abstract Article PDF–4.3M

Select item 1119320216.

Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients

Alicia J. Barber, Carmen L. del Genio, Anna Beth Swain, Elizabeth M. Pizzi, Sarah C. Watson, Vedant N. Tapiavala, George J. Zanazzi, Arti B. Gaur

Alzheimers Res Ther. 2024; 16: 134. Published online 2024 Jun 22. doi: 10.1186/s13195-024-01492-x

PMCID:: PMC11193202

Abstract Article PDF–3.9M

Select item 1119273317.

The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains

Tee Jong Huat, Judith Camats-Perna, Estella A. Newcombe, Tessa Onraet, Daniel Campbell, Josiah T. Sucic, Alessandra Martini, Stefânia Forner, Mehdi Mirzaei, Wayne Poon, Frank M. LaFerla, Rodrigo Medeiros

Sci Rep. 2024; 14: 14305. Published online 2024 Jun 21. doi: 10.1038/s41598-024-65248-1

PMCID:: PMC11192733

Abstract Article PDF–8.6M

Select item 1118950718.

Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease

Reji Babygirija, Michelle M. Sonsalla, Jericha Mill, Isabella James, Jessica H. Han, Cara L. Green, Mariah F. Calubag, Gina Wade, Anna Tobon, John Michael, Michaela M. Trautman, Ryan Matoska, Chung-Yang Yeh, Isaac Grunow, Heidi H. Pak, Michael J. Rigby, Dominique A. Baldwin, Natalie M. Niemi, John M. Denu, Luigi Puglielli, Judith Simcox, Dudley W. Lamming

Nat Commun. 2024; 15: 5217. Published online 2024 Jun 18. doi: 10.1038/s41467-024-49589-z

PMCID:: PMC11189507

Abstract Article PDF–3.1M

Select item 1116819119.

Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease

Sunghwa Kim, Irfan Ullah, Jagadish Beloor, Kunho Chung, Jongkil Kim, Yujong Yi, Eunhwa Kang, Gyeongju Yun, Seoyoun Heo, Seon-Hong Pyun, Seung Hyun Kim, Priti Kumar, Sang-Kyung Lee

Biomater Res. 2024; 28: 0027. Published online 2024 Jun 12. doi: 10.34133/bmr.0027

PMCID:: PMC11168191

Abstract Article PDF–3.6M

Select item 1114441720.

Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer’s Disease

En-Yi Lin, Shao-Xi Hsu, Bing-Hua Wu, Yu-Chen Deng, Wei Wuli, Yuan-Sheng Li, Jui-Hao Lee, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou

Int J Nanomedicine. 2024; 19: 4977–4994. Published online 2024 May 29. doi: 10.2147/IJN.S442876

PMCID:: PMC11144417

Abstract Article PDF–8.4M

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