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Select item 115378261.

Dermal TRPV1 innervations engage a macrophage and fibroblast containing pathway to activate hair growth in mice

Tamar L Ben-Shaanan, Konrad Knöpper, Lihui Duan, Ruiqi Liu, Hanna Taglinao, Ying Xu, Jinping An, Maksim V. Plikus, Jason G Cyster

Dev Cell. Author manuscript; available in PMC 2024 Nov 6.

Published in final edited form as: Dev Cell. 2024 Nov 4; 59(21): 2818–2833.e7. Published online 2024 Jun 7. doi: 10.1016/j.devcel.2024.05.019

PMCID:: PMC11537826

Abstract Article PDF–2.4M

Select item 111801882.

Intra-islet α-cell Gs signaling promotes glucagon release

Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess

Nat Commun. 2024; 15: 5129. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49537-x

Correction in:: Nat Commun. 2024; 15: 6383.

PMCID:: PMC11180188

Abstract Article PDF–3.0M

Select item 111366873.

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

CHAO TANG, CHUNYU ZHONG, JUNHAO ZHU, FENG YUAN, JIN YANG, YONG XU, CHIYUAN MA

Oncol Res. 2024; 32(6): 1079–1091. Published online 2024 May 23. doi: 10.32604/or.2024.046007

PMCID:: PMC11136687

Abstract Article PDF–16M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107351695.

The GPCR–Gα_s–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Victoria H. Wu, Bryan S. Yung, Farhoud Faraji, Robert Saddawi-Konefka, Zhiyong Wang, Alexander T. Wenzel, Miranda J. Song, Meghana S. Pagadala, Lauren M. Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas S. Hoang, Rebecca Berdeaux, Dario A. A. Vignali, Ramiro Iglesias-Bartolome, Hannah Carter, Eytan Ruppin, Jill P. Mesirov, J. Silvio Gutkind

Nat Immunol. Author manuscript; available in PMC 2023 Dec 21.

Published in final edited form as: Nat Immunol. 2023 Aug; 24(8): 1318–1330. Published online 2023 Jun 12. doi: 10.1038/s41590-023-01529-7

PMCID:: PMC10735169

Abstract Article PDF–3.8M

Select item 101591656.

Diurnal regulation of metabolism by G_s-alpha in hypothalamic QPLOT neurons

Kevin D. Gaitonde, Mutahar Andrabi, Courtney A. Burger, Shane P. D’Souza, Shruti Vemaraju, Bala S. C. Koritala, David F. Smith, Richard A. Lang

PLoS One. 2023; 18(5): e0284824. Published online 2023 May 4. doi: 10.1371/journal.pone.0284824

PMCID:: PMC10159165

Abstract Article PDF–3.9M

Select item 101318427.

GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer

Junwei Tang, Wen Peng, Jiangzhou Ji, Chaofan Peng, Tuo Wang, Peng Yang, Ji'ou Gu, Yifei Feng, Kangpeng Jin, Xiaowei Wang, Yueming Sun

Adv Sci (Weinh) 2023 Apr; 10(12): 2205627. Published online 2023 Mar 11. doi: 10.1002/advs.202205627

PMCID:: PMC10131842

Abstract Article PDF–5.8M

Select item 100774728.

Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice

Srilatha Swami, Hui Zhu, Aria Nisco, Takaharu Kimura, Matthew J. Kim, Vaisakh Nair, Joy Y. Wu

JCI Insight. 2023 Mar 8; 8(5): e157390. Published online 2023 Mar 8. doi: 10.1172/jci.insight.157390

PMCID:: PMC10077472

Abstract Article PDF–2.1M

Select item 99382169.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 966590210.

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S. Weinstein, Stefan Offermanns

J Exp Med. 2023 Jan 2; 220(1): e20211628. Published online 2022 Nov 14. doi: 10.1084/jem.20211628

PMCID:: PMC9665902

Abstract Article PDF–8.1M

Select item 935814011.

Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis

Lifan He, Hanlin Lu, Jianying Chu, Xiaoteng Qin, Jiangang Gao, Min Chen, Lee S. Weinstein, Jianmin Yang, Qunye Zhang, Cheng Zhang, Wencheng Zhang

Front Cardiovasc Med. 2022; 9: 941946. Published online 2022 Jul 25. doi: 10.3389/fcvm.2022.941946

PMCID:: PMC9358140

Abstract Article PDF–5.6M

Select item 926635612.

Gnas Loss Causes Chondrocyte Fate Conversion in Cranial Suture Formation

R. Xu, Y. Liu, Y. Zhou, W. Lin, Q. Yuan, X. Zhou, Y. Yang

J Dent Res. 2022 Jul; 101(8): 931–941. Published online 2022 Feb 26. doi: 10.1177/00220345221075215

PMCID:: PMC9266356

Abstract Article PDF–3.3M

Select item 920252313.

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang

Cell Rep. Author manuscript; available in PMC 2022 Jun 16.

Published in final edited form as: Cell Rep. 2021 Sep 21; 36(12): 109742. doi: 10.1016/j.celrep.2021.109742

PMCID:: PMC9202523

Abstract Article PDF–4.2M

Select item 901455914.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 897783815.

PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells

Amy M. Chinn, Cristina Salmerón, Jihyung Lee, Krishna Sriram, Eyal Raz, Paul A. Insel

Front Pharmacol. 2022; 13: 833832. Published online 2022 Mar 21. doi: 10.3389/fphar.2022.833832

PMCID:: PMC8977838

Abstract Article PDF–1.5M

Select item 877100216.

Parental Origin of Gsα Inactivation Differentially Affects Bone Remodeling in a Mouse Model of Albright Hereditary Osteodystrophy

Patrick McMullan, Peter Maye, Qingfen Yang, David W. Rowe, Emily L. Germain‐Lee

JBMR Plus. 2022 Jan; 6(1): e10570. Published online 2021 Nov 16. doi: 10.1002/jbm4.10570

PMCID:: PMC8771002

Abstract Article PDF–11M

Select item 872839917.

In vivo metabolic effects after acute activation of skeletal muscle G_s signaling

Jaroslawna Meister, Derek B.J. Bone, Jonas R. Knudsen, Luiz F. Barella, Liu Liu, Regina Lee, Oksana Gavrilova, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Thomas E. Jensen, Jürgen Wess

Mol Metab. 2022 Jan; 55: 101415. Published online 2021 Dec 6. doi: 10.1016/j.molmet.2021.101415

PMCID:: PMC8728399

Abstract Article PDF–2.2M

Select item 871175918.

Deletion of Gα_q/11 or Gα_s Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice

George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R Thompson, Rona S Carroll, Min Chen, Lee S Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J Bernard, Ursula B Kaiser

Endocrinology. 2022 Feb; 163(2): bqab247. Published online 2021 Dec 5. doi: 10.1210/endocr/bqab247

PMCID:: PMC8711759

Abstract Article

Select item 831323919.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826036320.

G_qα/G₁₁α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity

Eric A. Wilson, Hui Sun, Zhenzhong Cui, Marshal T. Jahnke, Mritunjay Pandey, Peter Metzger, Oksana Gavrilova, Min Chen, Lee S. Weinstein

Am J Physiol Endocrinol Metab. 2021 Feb 1; 320(2): E270–E280. Published online 2020 Nov 9. doi: 10.1152/ajpendo.00059.2020

PMCID:: PMC8260363

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