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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108383062.

The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity

Xue Fan Wang, Robin Vigouroux, Michal Syonov, Yuriy Baglaenko, Angeliki M. Nikolakopoulou, Dene Ringuette, Horea Rus, Peter V. DiStefano, Suzie Dufour, Alireza P. Shabanzadeh, Seunggi Lee, Bernhard K. Mueller, Jason Charish, Hidekiyo Harada, Jason E. Fish, Joan Wither, Thomas Wälchli, Jean-François Cloutier, Berislav V. Zlokovic, Peter L. Carlen, Philippe P. Monnier

Nat Commun. 2024; 15: 1037. Published online 2024 Feb 3. doi: 10.1038/s41467-024-45303-1

PMCID:: PMC10838306

Abstract Article PDF–4.4M

Select item 107882693.

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang

iScience. 2024 Jan 19; 27(1): 108722. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108722

PMCID:: PMC10788269

Abstract Article PDF–11M

Select item 98649024.

Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice

Edouard Charlebois, Yupeng Li, Victoria Wagner, Kostas Pantopoulos, Martin Olivier

Int J Mol Sci. 2023 Jan; 24(2): 1669. Published online 2023 Jan 14. doi: 10.3390/ijms24021669

PMCID:: PMC9864902

Abstract Article PDF–3.3M

Select item 88638325.

Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma

Abdolamir Allameh, Nico Hüttmann, Edouard Charlebois, Angeliki Katsarou, Wen Gu, Konstantinos Gkouvatsos, Elisa Pasini, Mamatha Bhat, Zoran Minic, Maxim Berezovski, Maria Guido, Carine Fillebeen, Kostas Pantopoulos

Commun Biol. 2022; 5: 153. Published online 2022 Feb 22. doi: 10.1038/s42003-022-03108-2

PMCID:: PMC8863832

Abstract Article PDF–9.9M

Select item 83704646.

Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin expression and iron homeostasis in mice

Caroline A. Enns, Shall Jue, An-Sheng Zhang

Blood. 2021 Aug 12; 138(6): 486–499. Prepublished online 2021 Apr 6. doi: 10.1182/blood.2020009485

PMCID:: PMC8370464

Abstract Article

Select item 79617627.

Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice

Jan Krijt, Jana Frýdlová, Iuliia Gurieva, Petr Přikryl, Martin Báječný, Andrea U. Steinbicker, Martin Vokurka, Jaroslav Truksa

Int J Mol Sci. 2021 Mar; 22(5): 2650. Published online 2021 Mar 6. doi: 10.3390/ijms22052650

PMCID:: PMC7961762

Abstract Article PDF–3.4M

Select item 77319098.

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

Maja Vujić Spasić, Richard Sparla, Katarzyna Mleczko-Sanecka, Mary C. Migas, Katja Breitkopf-Heinlein, Steven Dooley, Sophie Vaulont, Robert E. Fleming, Martina U. Muckenthaler

Biochim Biophys Acta. Author manuscript; available in PMC 2020 Dec 11.

Published in final edited form as: Biochim Biophys Acta. 2013 Jan; 1832(1): 76–84. Published online 2012 Aug 31. doi: 10.1016/j.bbadis.2012.08.013

PMCID:: PMC7731909

Abstract Article PDF–1.8M

Select item 72383689.

The functional role of hemojuvelin in acute ischemic stroke

Guang-Huar Young, Sung-Chun Tang, Vin-Cent Wu, Kuo-Chuan Wang, Jing-Yi Nong, Po-Yuan Huang, Chaur-Jong Hu, Hung-Yi Chiou, Jiann-Shing Jeng, Chung Y Hsu

J Cereb Blood Flow Metab. 2020 Jun; 40(6): 1316–1327. Published online 2019 Jul 15. doi: 10.1177/0271678X19861448

PMCID:: PMC7238368

Abstract Article PDF–1.3M

Select item 673038510.

DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties

Tarek A. Samad, Ashok Srinivasan, Laurie A. Karchewski, Sung-Jin Jeong, Jason A. Campagna, Ru-Rong Ji, David A. Fabrizio, Ying Zhang, Herbert Y. Lin, Esther Bell, Clifford J. Woolf

J Neurosci. 2004 Feb 25; 24(8): 2027–2036. doi: 10.1523/JNEUROSCI.4115-03.2004

PMCID:: PMC6730385

Abstract Article PDF–873K

Select item 672981711.

Repulsive Guidance Molecule (RGM) Gene Function Is Required for Neural Tube Closure But Not Retinal Topography in the Mouse Visual System

Vera Niederkofler, Rishard Salie, Markus Sigrist, Silvia Arber

J Neurosci. 2004 Jan 28; 24(4): 808–818. doi: 10.1523/JNEUROSCI.4610-03.2004

PMCID:: PMC6729817

Abstract Article PDF–1.4M

Select item 670755812.

Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet

John Wagner, Carine Fillebeen, Tina Haliotis, Edouard Charlebois, Angeliki Katsarou, Jeannie Mui, Hojatollah Vali, Kostas Pantopoulos

PLoS One. 2019; 14(8): e0221455. Published online 2019 Aug 23. doi: 10.1371/journal.pone.0221455

PMCID:: PMC6707558

Abstract Article PDF–7.4M

Select item 659640413.

Hemojuvelin is a novel suppressor for Duchenne muscular dystrophy and age‐related muscle wasting

Peng Zhang, Jian He, Fei Wang, Jing Gong, Lu Wang, Qian Wu, Wenjiong Li, Hongju Liu, Jing Wang, Kunshan Zhang, Mao Li, Xusheng Huang, Chuanqiang Pu, Ying Li, Fengjie Jiang, Fudi Wang, Junxia Min, Xiaoping Chen

J Cachexia Sarcopenia Muscle. 2019 Jun; 10(3): 557–573. Published online 2019 Mar 18. doi: 10.1002/jcsm.12414

PMCID:: PMC6596404

Abstract Article PDF–3.2M

Select item 567205614.

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Mastura Wahedi, Aaron M. Wortham, Mark D. Kleven, Ningning Zhao, Shall Jue, Caroline A. Enns, An-Sheng Zhang

J Biol Chem. 2017 Nov 3; 292(44): 18354–18371. Published online 2017 Sep 18. doi: 10.1074/jbc.M117.801795

PMCID:: PMC5672056

Abstract Article PDF–3.3M

Select item 565809115.

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice

Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt

PLoS One. 2017; 12(10): e0186844. Published online 2017 Oct 26. doi: 10.1371/journal.pone.0186844

PMCID:: PMC5658091

Abstract Article PDF–13M

Select item 550326116.

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program

John P. Sundberg, Soheil S. Dadras, Kathleen A. Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N. Schofield, C. Herbert Pratt

PLoS One. 2017; 12(7): e0180682. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180682

PMCID:: PMC5503261

Abstract Article PDF–31M

Select item 529582117.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 529347818.

Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study

Seppo T. Nikkari, Anni-Laura Visto, Kirsi M. Määttä, Tarja A. Kunnas

Medicine (Baltimore) 2017 Feb; 96(5): e6052. Published online 2017 Feb 3. doi: 10.1097/MD.0000000000006052

PMCID:: PMC5293478

Abstract Article PDF–183K

Select item 527038919.

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

Susanna Canali, Kimberly B. Zumbrennen-Bullough, Amanda B. Core, Chia-Yu Wang, Manfred Nairz, Richard Bouley, Filip K. Swirski, Jodie L. Babitt

Blood. 2017 Jan 26; 129(4): 405–414. Prepublished online 2016 Nov 18. doi: 10.1182/blood-2016-06-721571

PMCID:: PMC5270389

Abstract Article

Select item 500435920.

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels

Suzana Kovac, Preethne Böser, Yifang Cui, Dunja Ferring-Appel, Daniela Casarrubea, Lili Huang, Emma Fung, Andreas Popp, Bernhard K. Mueller, Matthias W. Hentze

Haematologica. 2016 May; 101(5): e173–e176. doi: 10.3324/haematol.2015.140772

PMCID:: PMC5004359

Article PDF–1.0M

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