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Select item 112903221.

The primitive endoderm supports lineage plasticity to enable regulative development

Madeleine Linneberg-Agerholm, Annika Charlotte Sell, Alba Redó-Riveiro, Marta Perera, Martin Proks, Teresa E. Knudsen, Antonio Barral, Miguel Manzanares, Joshua M. Brickman

Cell. 2024 Jul 25; 187(15): 4010–4029.e16. doi: 10.1016/j.cell.2024.05.051

PMCID:: PMC11290322

Abstract Article

Select item 112608702.

The protective role of GATA6⁺ pericardial macrophages in pericardial inflammation

David M. Hughes, Taejoon Won, Monica V. Talor, Hannah M. Kalinoski, Ivana Jurčová, Ondrej Szárszoi, Ilja Stříž, Lenka Čurnová, William Bracamonte-Baran, Vojtěch Melenovský, Daniela Čiháková

iScience. 2024 Jul 19; 27(7): 110244. Published online 2024 Jun 13. doi: 10.1016/j.isci.2024.110244

PMCID:: PMC11260870

Abstract Article PDF–7.2M

Select item 111905793.

Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation

Robin E. Kruger, Tristan Frum, A. Sophie Brumm, Stephanie L. Hickey, Kathy K. Niakan, Farina Aziz, Marcelio A. Shammami, Jada G. Roberts, Amy Ralston

Development. 2024 Jun 1; 151(11): dev202377. Published online 2024 Jun 5. doi: 10.1242/dev.202377

PMCID:: PMC11190579

Abstract Article

Select item 110041804.

Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis

Naveen Kumar, Pon Ganish Prakash, Christian Wentland, Shilpa Mary Kurian, Gaurav Jethva, Volker Brinkmann, Hans-Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine-Emmanuel Saliba, Matthias Biebl, Christian Jürgensen, Bertram Wiedenmann, Thomas F. Meyer, Rajendra Kumar Gurumurthy, Cindrilla Chumduri

Nat Commun. 2024; 15: 3064. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47173-z

PMCID:: PMC11004180

Abstract Article PDF–23M

Select item 109626985.

Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells

Mehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar, Matthew P. Stokes, Vincent Giguère, Randal J. Kaufman, Yojiro Yamanaka, Pavel V. Baranov, Soroush Tahmasebi, Nahum Sonenberg

Cell Rep. Author manuscript; available in PMC 2024 Mar 25.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113615. Published online 2023 Dec 29. doi: 10.1016/j.celrep.2023.113615

PMCID:: PMC10962698

Abstract Article PDF–2.5M

Select item 107582926.

Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness

Shreeta Chakraborty, Nina Kopitchinski, Zhenyu Zuo, Ariel Eraso, Parirokh Awasthi, Raj Chari, Apratim Mitra, Ian C. Tobias, Sakthi D. Moorthy, Ryan K. Dale, Jennifer A. Mitchell, Timothy J. Petros, Pedro P. Rocha

Nat Genet. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Nat Genet. 2023 Feb; 55(2): 280–290. Published online 2023 Jan 30. doi: 10.1038/s41588-022-01295-6

PMCID:: PMC10758292

Abstract Article PDF–4.9M

Select item 106564277.

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter

Jennifer Kurz, Anna-Carina Weiss, Timo H.-W. Lüdtke, Lena Deuper, Mark-Oliver Trowe, Hauke Thiesler, Herbert Hildebrandt, Joerg Heineke, Stephen A. Duncan, Andreas Kispert

Development. 2022 Aug 1; 149(15): dev200522. Published online 2022 Jul 29. doi: 10.1242/dev.200522

PMCID:: PMC10656427

Abstract Article

Select item 103634308.

Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways

Wenrun Wu, Wenzhen Bao, Xiaoli Chen, Yushi Lu, Ji Fang, Jiwen Liu, Sheng Peng, Jingjiang Pi, Brian Tomlinson, Paul Chan, Qi Zhang, Lin Zhang, Zhongmin Liu, Jie Liu, Yuzhen Zhang, Tao Zhuang

Redox Biol. 2023 Aug; 64: 102775. Published online 2023 Jun 12. doi: 10.1016/j.redox.2023.102775

Correction in:: Redox Biol. 2023 Oct; 66: 102854.

PMCID:: PMC10363430

Abstract Article PDF–9.5M

Select item 103589679.

Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo

Marcelo D. Goissis, Brian Bradshaw, Eszter Posfai, Janet Rossant

PLoS One. 2023; 18(7): e0279515. Published online 2023 Jul 20. doi: 10.1371/journal.pone.0279515

PMCID:: PMC10358967

Abstract Article PDF–1.5M

Select item 1019220810.

Genome-wide analysis of sex-specific differences in the mother–child PELAGIE cohort exposed to organophosphate metabolites

Martina Capriati, Chunxiang Hao, Shereen Cynthia D’Cruz, Christine Monfort, Cecile Chevrier, Charline Warembourg, Fatima Smagulova

Sci Rep. 2023; 13: 8003. Published online 2023 May 17. doi: 10.1038/s41598-023-35113-8

PMCID:: PMC10192208

Abstract Article PDF–3.0M

Select item 1018547011.

Tissue memory relies on stem cell priming in distal undamaged areas

Chiara Levra Levron, Mika Watanabe, Valentina Proserpio, Gabriele Piacenti, Andrea Lauria, Stefan Kaltenbach, Annalaura Tamburrini, Takuma Nohara, Francesca Anselmi, Carlotta Duval, Luca Elettrico, Daniela Donna, Laura Conti, Denis Baev, Ken Natsuga, Tzachi Hagai, Salvatore Oliviero, Giacomo Donati

Nat Cell Biol. 2023; 25(5): 740–753. Published online 2023 Apr 20. doi: 10.1038/s41556-023-01120-0

PMCID:: PMC10185470

Abstract Article PDF–29M

Select item 1012265712.

GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension

Tetsuo Toyama, Tatiana V. Kudryashova, Asako Ichihara, Stefania Lenna, Agnieszka Looney, Yuanjun Shen, Lifeng Jiang, Leyla Teos, Theodore Avolio, Derek Lin, Ulas Kaplan, Grace Marden, Vrinda Dambal, Dmitry Goncharov, Horace Delisser, Robert Lafyatis, Francesca Seta, Elena A. Goncharova, Maria Trojanowska

Sci Rep. 2023; 13: 6593. Published online 2023 Apr 22. doi: 10.1038/s41598-023-33779-8

PMCID:: PMC10122657

Abstract Article PDF–4.1M

Select item 999750613.

Aldh1a2⁺ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots

Tomomi Yoshihara, Yasutaka Okabe

J Exp Med. 2023 May 1; 220(5): e20221813. Published online 2023 Feb 28. doi: 10.1084/jem.20221813

PMCID:: PMC9997506

Abstract Article PDF–6.8M

Select item 998453414.

The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

Paraskevi Athanasouli, Martina Balli, Anchel De Jaime-Soguero, Annekatrien Boel, Sofia Papanikolaou, Bernard K. van der Veer, Adrian Janiszewski, Tijs Vanhessche, Annick Francis, Youssef El Laithy, Antonio Lo Nigro, Francesco Aulicino, Kian Peng Koh, Vincent Pasque, Maria Pia Cosma, Catherine Verfaillie, An Zwijsen, Björn Heindryckx, Christoforos Nikolaou, Frederic Lluis

Nat Commun. 2023; 14: 1210. Published online 2023 Mar 3. doi: 10.1038/s41467-023-36914-1

PMCID:: PMC9984534

Abstract Article PDF–3.7M

Select item 973363415.

A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

Bernhard Kloesch, Vivien Ionasz, Sumit Paliwal, Natascha Hruschka, Jaime Martinez de Villarreal, Rupert Öllinger, Sebastian Mueller, Hans Peter Dienes, Martin Schindl, Elisabeth S Gruber, Judith Stift, Dietmar Herndler-Brandstetter, Gwen A Lomberk, Barbara Seidler, Dieter Saur, Roland Rad, Raul A Urrutia, Francisco X Real, Paola Martinelli

Gut. 2022 Apr; 71(4): 766–777. Published online 2021 Apr 12. doi: 10.1136/gutjnl-2020-321397

PMCID:: PMC9733634

Abstract Article PDF–24M

Select item 968706516.

Progression of the pluripotent epiblast depends upon the NMD factor UPF2

Jennifer N. Chousal, Abhishek Sohni, Kristoffer Vitting-Seerup, Kyucheol Cho, Matthew Kim, Kun Tan, Bo Porse, Miles F. Wilkinson, Heidi Cook-Andersen

Development. 2022 Nov 1; 149(21): dev200764. Published online 2022 Nov 7. doi: 10.1242/dev.200764

Correction in:: Development. 2024 Jun 15; 151(12): dev203145.

PMCID:: PMC9687065

Abstract Article

Select item 963583117.

Early developmental plasticity enables the induction of an intermediate extraembryonic cell state

Anusha Sathyanarayanan, Elizabeth Ing-Simmons, Rui Chen, Hyun-Woo Jeong, Hatice O. Ozguldez, Rui Fan, Binyamin Duethorn, Kee-Pyo Kim, Yung Su Kim, Martin Stehling, Heike Brinkmann, Hans R. Schöler, Ralf H. Adams, Juan M. Vaquerizas, Ivan Bedzhov

Sci Adv. 2022 Nov; 8(44): eabl9583. Published online 2022 Nov 4. doi: 10.1126/sciadv.abl9583

PMCID:: PMC9635831

Abstract Article PDF–17M

Select item 953477218.

Embryo model completes gastrulation to neurulation and organogenesis

Gianluca Amadei, Charlotte E. Handford, Chengxiang Qiu, Joachim De Jonghe, Hannah Greenfeld, Martin Tran, Beth K. Martin, Dong-Yuan Chen, Alejandro Aguilera-Castrejon, Jacob H. Hanna, Michael B. Elowitz, Florian Hollfelder, Jay Shendure, David M. Glover, Magdalena Zernicka-Goetz

Nature. 2022; 610(7930): 143–153. Published online 2022 Aug 25. doi: 10.1038/s41586-022-05246-3

PMCID:: PMC9534772

Abstract Article PDF–29M

Select item 948085619.

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription

Abderhman Abuhashem, Alexandra G. Chivu, Yixin Zhao, Edward J. Rice, Adam Siepel, Charles G. Danko, Anna-Katerina Hadjantonakis

Genes Dev. 2022 Jul 1; 36(13-14): 770–789. doi: 10.1101/gad.349565.122

PMCID:: PMC9480856

Abstract Article PDF–11M

Select item 943972120.

Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs

Shadi Tarazi, Alejandro Aguilera-Castrejon, Carine Joubran, Nadir Ghanem, Shahd Ashouokhi, Francesco Roncato, Emilie Wildschutz, Montaser Haddad, Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza, Noa Novershtern, Jacob H. Hanna

Cell. 2022 Sep 1; 185(18): 3290–3306.e25. doi: 10.1016/j.cell.2022.07.028

PMCID:: PMC9439721

Abstract Article

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