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Select item 111677761.

Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig

Cell Commun Signal. 2024; 22: 322. Published online 2024 Jun 11. doi: 10.1186/s12964-024-01690-y

PMCID:: PMC11167776

Abstract Article PDF–11M

Select item 111052472.

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15

Lisa Seipold, Hermann Altmeppen, Tomas Koudelka, Andreas Tholey, Petr Kasparek, Radislav Sedlacek, Michaela Schweizer, Julia Bär, Marina Mikhaylova, Markus Glatzel, Paul Saftig

Cell Mol Life Sci. 2018 Sep; 75(17): 3251–3267. Published online 2018 Mar 8. doi: 10.1007/s00018-018-2791-2

PMCID:: PMC11105247

Abstract Article PDF–4.2M

Select item 111050093.

Degradome of soluble ADAM10 and ADAM17 metalloproteases

Franka Scharfenberg, Andreas Helbig, Martin Sammel, Julia Benzel, Uwe Schlomann, Florian Peters, Rielana Wichert, Maximilian Bettendorff, Dirk Schmidt-Arras, Stefan Rose-John, Catherine Moali, Stefan F. Lichtenthaler, Claus U. Pietrzik, Jörg W. Bartsch, Andreas Tholey, Christoph Becker-Pauly

Cell Mol Life Sci. 2020 Jan; 77(2): 331–350. Published online 2019 Jun 17. doi: 10.1007/s00018-019-03184-4

PMCID:: PMC11105009

Abstract Article PDF–2.2M

Select item 109535814.

SHMT2 Mediates Small‐Molecule‐Induced Alleviation of Alzheimer Pathology Via the 5′UTR‐dependent ADAM10 Translation Initiation

Li Song, Qiu‐Ling Pan, Gui‐Feng Zhou, Sheng‐Wei Liu, Bing‐Lin Zhu, Pei‐Jia Lin, Xiao‐Tong Hu, Jing‐Si Zha, Yan Long, Biao Luo, Jian Chen, Ying Tang, Jing Tang, Xiao‐Jiao Xiang, Xiao‐Yong Xie, Xiao‐Juan Deng, Guo‐Jun Chen

Adv Sci (Weinh) 2024 Mar; 11(11): 2305260. Published online 2024 Jan 6. doi: 10.1002/advs.202305260

PMCID:: PMC10953581

Abstract Article PDF–11M

Select item 107314215.

Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

Fan Yang, Mingyi Suo, Homayemem Weli, Mason Wong, Alex Junidi, Celeste Cummings, Ryan Johnson, Kiara Mallory, Annie Y. Liu, Zev J. Greenberg, Laura G. Schuettpelz, Mark J. Miller, Cliff J. Luke, Gwendalyn J. Randolph, Bernd H. Zinselmeyer, Juliane Bubeck Wardenburg, Regina A. Clemens

Cell Rep. Author manuscript; available in PMC 2023 Dec 20.

Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113394. Published online 2023 Nov 10. doi: 10.1016/j.celrep.2023.113394

PMCID:: PMC10731421

Abstract Article PDF–2.8M

Select item 106889916.

Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis

Danielle N. Alfano, Mark J. Miller, Juliane Bubeck Wardenburg

J Clin Invest. 2023 Dec 1; 133(23): e168450. Published online 2023 Dec 1. doi: 10.1172/JCI168450

PMCID:: PMC10688991

Abstract Article PDF–2.7M

Select item 104675687.

Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin

Benjamin Voisin, Vinod Nadella, Thomas Doebel, Shubham Goel, Keiko Sakamoto, Otgonzaya Ayush, Jay-Hyun Jo, Michael C. Kelly, Tetsuro Kobayashi, Jean X. Jiang, Ying Hu, Chunhua Yan, Keisuke Nagao

Immunity. Author manuscript; available in PMC 2024 Jul 11.

Published in final edited form as: Immunity. 2023 Jul 11; 56(7): 1561–1577.e9. Published online 2023 Jul 3. doi: 10.1016/j.immuni.2023.06.006

PMCID:: PMC10467568

Abstract Article PDF–3.5M

Select item 100234208.

Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer’s disease

Suresh B. Rangasamy, Malabendu Jana, Sridevi Dasarathi, Madhuchhanda Kundu, Kalipada Pahan

Brain Behav Immun. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Brain Behav Immun. 2023 Mar; 109: 204–218. Published online 2023 Jan 19. doi: 10.1016/j.bbi.2023.01.009

Correction in:: Brain Behav Immun. 2024 Oct; 121: 407–409.

PMCID:: PMC10023420

Abstract Article PDF–3.6M

Select item 99114179.

Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice

Emiel P. C. van der Vorst, Sanne L. Maas, Kosta Theodorou, Linsey J. F. Peters, Han Jin, Timo Rademakers, Marion J. Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F. Bentzon, Erik A. L. Biessen, Marjo M. P. C. Donners

Front Cardiovasc Med. 2023; 10: 974918. Published online 2023 Jan 27. doi: 10.3389/fcvm.2023.974918

PMCID:: PMC9911417

Abstract Article PDF–1.5M

Select item 989919110.

A Disintegrin and Metalloproteinase 10 (ADAM10) Is Essential for Oligodendrocyte Precursor Development and Myelination in the Mouse Brain

Dazhi Guo, Fei Huang, Ruijun Xue, Yuehong Ma, Lin Xiao, Huifang Lou, Shuyi Pan

Mol Neurobiol. 2023; 60(3): 1675–1689. Published online 2022 Dec 23. doi: 10.1007/s12035-022-03163-0

PMCID:: PMC9899191

Abstract Article PDF–2.6M

Select item 974159911.

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction

Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche

Nat Commun. 2022; 13: 7648. Published online 2022 Dec 10. doi: 10.1038/s41467-022-35331-0

PMCID:: PMC9741599

Abstract Article PDF–2.1M

Select item 940647112.

2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer’s Disease

Bong-Geum Jang, Boyoung Choi, Suyeon Kim, Duk-Shin Lee, Jisun Lee, Young Ho Koh, Sangmee Ahn Jo, Ji-Eun Kim, Tae-Cheon Kang, Min-Ju Kim

Cells. 2022 Aug; 11(16): 2585. Published online 2022 Aug 19. doi: 10.3390/cells11162585

PMCID:: PMC9406471

Abstract Article PDF–5.7M

Select item 926325813.

The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease

Stefano Musardo, Sebastien Therin, Silvia Pelucchi, Laura D’Andrea, Ramona Stringhi, Ana Ribeiro, Annalisa Manca, Claudia Balducci, Jessica Pagano, Carlo Sala, Chiara Verpelli, Valeria Grieco, Valeria Edefonti, Gianluigi Forloni, Fabrizio Gardoni, Giovanni Meli, Daniele Di Marino, Monica Di Luca, Elena Marcello

Mol Ther. 2022 Jul 6; 30(7): 2474–2490. Published online 2022 Apr 4. doi: 10.1016/j.ymthe.2022.03.024

PMCID:: PMC9263258

Abstract Article PDF–3.2M

Select item 912757814.

The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo

Sophia Kirschke, Ireti Ogunsulire, Balachandar Selvakumar, Neele Schumacher, Tanya Sezin, Stefan Rose-John, Alexander Scheffold, Christoph Garbers, Juliane Lokau

J Biol Chem. 2022 Jun; 298(6): 101910. Published online 2022 Apr 7. doi: 10.1016/j.jbc.2022.101910

PMCID:: PMC9127578

Abstract Article PDF–1.3M

Select item 909848515.

ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis

Chenchen Cai, Miaomiao Zhang, Lei Liu, Haoliang Zhang, Yi Guo, Ting Lan, Yinhai Xu, Ping Ma, Shibao Li

Cell Death Dis. 2022 May; 13(5): 453. Published online 2022 May 12. doi: 10.1038/s41419-022-04893-8

PMCID:: PMC9098485

Abstract Article PDF–4.9M

Select item 898800816.

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju

J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787

PMCID:: PMC8988008

Abstract Article PDF–6.1M

Select item 890571717.

shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing

Maria Czarnek, Krystyna Stalińska, Katarzyna Sarad, Joanna Bereta

Biol Open. 2022 Mar 15; 11(3): bio059092. Published online 2022 Mar 4. doi: 10.1242/bio.059092

PMCID:: PMC8905717

Abstract Article PDF–2.4M

Select item 860344118.

Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice

Nicole Lustgarten Guahmich, Gregory Farber, Shiva Shafiei, Dylan McNally, David Redmond, Eleni Kallinos, Heidi Stuhlmann, Daniel Dufort, Daylon James, Carl P. Blobel

Angiogenesis. Author manuscript; available in PMC 2021 Nov 19.

Published in final edited form as: Angiogenesis. 2020 Aug; 23(3): 443–458. Published online 2020 May 8. doi: 10.1007/s10456-020-09723-z

PMCID:: PMC8603441

Abstract Article PDF–3.5M

Select item 858035419.

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Xiang-Shu Cheng, Fang-Xiao Shi, Kun-Peng Zhao, Wang Lin, Xiao-Ying Li, Jun Zhang, Yao-Yao Bu, Rui Zhu, Xiao-Hong Li, Dong-Xiao Duan, Xin-Ying Ji, Jian-She Wei, Jian-Zhi Wang, Jin Du, Xin-Wen Zhou

Aging (Albany NY) 2021 Oct 31; 13(20): 23620–23636. Published online 2021 Oct 13. doi: 10.18632/aging.203634

PMCID:: PMC8580354

Abstract Article PDF–1.0M

Select item 852954020.

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease

Leann H. Brennaman, Marcia L. Moss, Patricia F. Maness

J Neurochem. Author manuscript; available in PMC 2021 Oct 21.

Published in final edited form as: J Neurochem. 2014 Jan; 128(2): 267–279. Published online 2013 Oct 21. doi: 10.1111/jnc.12468

PMCID:: PMC8529540

Abstract Article PDF–865K

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