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Items: 1 to 20 of 46

1.
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling, Stuart A. Cook
Nature. 2024; 632(8023): 157–165. Published online 2024 Jul 17. doi: 10.1038/s41586-024-07701-9
PMCID:
PMC11291288
AbstractArticlePDF–19M
2.
ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
Tao Zhuang, Mei-Hua Chen, Ruo-Xi Wu, Jing Wang, Xi-De Hu, Ting Meng, Ai-Hua Wu, Yan Li, Yong-Feng Yang, Yu Lei, Dong-Hua Hu, Yan-Xiu Li, Li Zhang, Ai-Jun Sun, Wei Lu, Guan-Nan Zhang, Jun-Li Zuo, Cheng-Chao Ruan
Nat Commun. 2024; 15: 1995. Published online 2024 Mar 5. doi: 10.1038/s41467-024-46357-x
Correction in:
Nat Commun. 2024; 15: 5595.
PMCID:
PMC10914760
AbstractArticlePDF–5.6M
3.
Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing
Aastha Singh, WonKyung J. Cho, Vinay K. Pulimamidi, Sharad K. Mittal, Sunil K. Chauhan
Invest Ophthalmol Vis Sci. 2023 Nov; 64(14): 1. Published online 2023 Nov 1. doi: 10.1167/iovs.64.14.1
PMCID:
PMC10627293
AbstractArticlePDF–6.4M
4.
Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation
Xiaodong Zhu, Yu Zhao, Yuqiu Liu, Wen Shi, Junlan Yang, Zhihong Liu, Xiaoliang Zhang
Cell Commun Signal. 2023; 21: 293. Published online 2023 Oct 18. doi: 10.1186/s12964-023-01327-6
PMCID:
PMC10585809
AbstractArticlePDF–11M
5.
Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction
Mark Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul J. R. Barton, Stuart A. Cook
Int J Mol Sci. 2023 Aug; 24(16): 12989. Published online 2023 Aug 20. doi: 10.3390/ijms241612989
PMCID:
PMC10455677
AbstractArticlePDF–3.0M
6.
IL11 activates the placental inflammasome to drive preeclampsia
Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell, Evdokia Dimitriadis
Front Immunol. 2023; 14: 1175926. Published online 2023 May 24. doi: 10.3389/fimmu.2023.1175926
PMCID:
PMC10244672
AbstractArticlePDF–15M
7.
IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer
Qian Zhao, Lu Qian, Yuefan Guo, Jinhui Lü, Danni Li, Heying Xie, Qiong Wang, Wenjing Ma, Pengfei Liu, Yu Liu, Tao Wang, Xuebiao Wu, Junyi Han, Zuoren Yu
Theranostics. 2023; 13(7): 2337–2349. Published online 2023 Apr 17. doi: 10.7150/thno.82538
PMCID:
PMC10157741
AbstractArticlePDF–6.8M
8.
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome
Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim
Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 739–754. Published online 2023 Apr 27. doi: 10.1161/ATVBAHA.122.318802
PMCID:
PMC10125130
AbstractArticlePDF–6.9M
9.
Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice
Takashi Nishina, Yutaka Deguchi, Mika Kawauchi, Chen Xiyu, Soh Yamazaki, Tetuo Mikami, Hiroyasu Nakano
iScience. 2023 Feb 17; 26(2): 105934. Published online 2023 Jan 5. doi: 10.1016/j.isci.2023.105934
PMCID:
PMC9852934
AbstractArticlePDF–4.0M
10.
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook
Nat Commun. 2022; 13: 7497. Published online 2022 Dec 5. doi: 10.1038/s41467-022-35306-1
PMCID:
PMC9723120
AbstractArticlePDF–7.9M
11.
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis
Bingzi Dong, Masahiro Hiasa, Yoshiki Higa, Yukiyo Ohnishi, Itsuro Endo, Takeshi Kondo, Yuichi Takashi, Maria Tsoumpra, Risa Kainuma, Shun Sawatsubashi, Hiroshi Kiyonari, Go Shioi, Hiroshi Sakaue, Tomoki Nakashima, Shigeaki Kato, Masahiro Abe, Seiji Fukumoto, Toshio Matsumoto
Nat Commun. 2022; 13: 7194. Published online 2022 Nov 23. doi: 10.1038/s41467-022-34869-3
PMCID:
PMC9691688
AbstractArticlePDF–3.9M
12.
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription
Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin
Aging Cell. 2022 Aug; 21(8): e13680. Published online 2022 Jul 30. doi: 10.1111/acel.13680
PMCID:
PMC9381906
AbstractArticlePDF–16M
13.
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis
Benjamin Ng, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Shamini G. Shekeran, Joyce Wei Ting Goh, Jessie Tan, Fathima Kuthubudeen, Sze Yun Lim, Chen Xie, Sebastian Schafer, Eleonora Adami, Stuart A. Cook
Int J Mol Sci. 2022 Apr; 23(7): 3549. Published online 2022 Mar 24. doi: 10.3390/ijms23073549
PMCID:
PMC8999048
AbstractArticlePDF–3.8M
14.
Krüppel‐Like Factor 15/Interleukin 11 Axis‐Mediated Adventitial Remodeling Depends on Extracellular Signal‐Regulated Kinases 1 and 2 Activation in Angiotensin II–Induced Hypertension
Yue‐Tong Guo, Yuan‐Yuan Lu, Xiao Lu, Shun He, Shi‐Jin Li, Shuai Shao, Han‐Dan Zhou, Rui‐Qi Wang, Xiao‐Dong Li, Ping‐Jin Gao
J Am Heart Assoc. 2021 Aug 17; 10(16): e020554. Published online 2021 Aug 5. doi: 10.1161/JAHA.120.020554
PMCID:
PMC8475029
AbstractArticlePDF–3.1M
15.
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook
Sci Rep. 2021; 11: 14088. Published online 2021 Jul 8. doi: 10.1038/s41598-021-93623-9
PMCID:
PMC8266813
AbstractArticlePDF–7.3M
16.
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano
Nat Commun. 2021; 12: 2281. Published online 2021 Apr 16. doi: 10.1038/s41467-021-22450-3
PMCID:
PMC8052408
AbstractArticlePDF–4.3M
17.
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
Wei-Wen Lim, Ben Corden, Benjamin Ng, Konstantinos Vanezis, Giuseppe D’Agostino, Anissa A. Widjaja, Wei-Hua Song, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G. Z. Tee, Jinrui Dong, Nicole S. J. Ko, Mao Wang, Chee Jian Pua, Muhammad H. Jamal, Beeyong Soh, Sivakumar Viswanathan, Sebastian Schafer, Stuart A. Cook
Sci Rep. 2020; 10: 17853. Published online 2020 Oct 20. doi: 10.1038/s41598-020-74944-7
PMCID:
PMC7576123
AbstractArticlePDF–14M
18.
Roles of interleukin-11 during acute bacterial pneumonia
Katrina E. Traber, Ernest L. Dimbo, Elise M. Symer, Filiz T. Korkmaz, Matthew R. Jones, Joseph P. Mizgerd, Lee J. Quinton
PLoS One. 2019; 14(8): e0221029. Published online 2019 Aug 15. doi: 10.1371/journal.pone.0221029
PMCID:
PMC6695241
AbstractArticlePDF–2.0M
19.
Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis
Ryodai Shindo, Masaki Ohmuraya, Sachiko Komazawa-Sakon, Sanae Miyake, Yutaka Deguchi, Soh Yamazaki, Takashi Nishina, Takayuki Yoshimoto, Soichiro Kakuta, Masato Koike, Yasuo Uchiyama, Hiroyuki Konishi, Hiroshi Kiyama, Tetuo Mikami, Kenta Moriwaki, Kimi Araki, Hiroyasu Nakano
iScience. 2019 May 31; 15: 536–551. Published online 2019 May 14. doi: 10.1016/j.isci.2019.05.011
PMCID:
PMC6538961
AbstractArticlePDF–19M
20.
IL-11 promotes the treatment efficacy of hematopoietic stem cell transplant therapy in aplastic anemia model mice through a NF-κB/microRNA-204/thrombopoietin regulatory axis
Yan Wang, Zhi-yun Niu, Yu-jie Guo, Li-hua Wang, Feng-ru Lin, Jing-yu Zhang
Exp Mol Med. 2017 Dec; 49(12): e410. Published online 2017 Dec 8. doi: 10.1038/emm.2017.217
PMCID:
PMC5750475
AbstractArticlePDF–1.3M

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