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Select item 111301441.

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control

Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, Jin Wang, Shenghao Zhang, Baocheng Zhao, Wenxing Cui, Yang Wu, Qiang Wang, Tian Feng, Haixiao Liu, Yan Qu, Shunnan Ge

Cell Death Dis. 2024 May; 15(5): 364. Published online 2024 May 27. doi: 10.1038/s41419-024-06748-w

Correction in:: Cell Death Dis. 2024 Jul; 15(7): 527.

PMCID:: PMC11130144

Abstract Article PDF–7.2M

Select item 110452242.

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

Anika Shimonty, Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua Huot, Hyeonwoo Kim, Clifford J Rosen, Bruce M Spiegelman, Lynda F Bonewald

eLife. 2024; 12: RP92263. Published online 2024 Apr 25. doi: 10.7554/eLife.92263

PMCID:: PMC11045224

Abstract Article PDF–9.2M

Select item 109818083.

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Qianqian Dong, Ziqi Han, Mingdong Gao, Limin Tian

J Orthop Surg Res. 2024; 19: 205. Published online 2024 Mar 30. doi: 10.1186/s13018-024-04701-3

PMCID:: PMC10981808

Abstract Article PDF–12M

Select item 107581054.

Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca²⁺-dependent endoplasmic reticulum stress in VSMCs

Ru-li Li, Cai-li Zhuo, Xin Yan, He Li, Lan Lin, Ling-yu Li, Qiying Jiang, Die Zhang, Xue-mei Wang, Lin-ling Liu, Wen-jing Huang, Ying-ling Wang, Xin-yue Li, Yan Mao, Yixin Chen, Xiao Liu, Quan-chen Xu, Yu-yan Cai, Xi-jing Yang, Hong-ying Chen, Si-si Wu, Wei Jiang

Int J Biol Sci. 2024; 20(2): 680–700. Published online 2024 Jan 1. doi: 10.7150/ijbs.84153

PMCID:: PMC10758105

Abstract Article PDF–12M

Select item 103175385.

Exercise hormone irisin is a critical regulator of cognitive function

Mohammad R. Islam, Sophia Valaris, Michael F. Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond, Sofia Mazuera, Robert R. Kitchen, Barbara J. Caldarone, Luis E.B. Bettio, Brian R. Christie, Angela B. Schmider, Roy J. Soberman, Antoine Besnard, Mark P. Jedrychowski, Hyeonwoo Kim, Hua Tu, Eunhee Kim, Se Hoon Choi, Rudolph E. Tanzi, Bruce M. Spiegelman, Christiane D. Wrann

Nat Metab. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Nat Metab. 2021 Aug; 3(8): 1058–1070. Published online 2021 Aug 20. doi: 10.1038/s42255-021-00438-z

Correction in:: Nat Metab. 2021 Oct 7

PMCID:: PMC10317538

Abstract Article PDF–6.4M

Select item 101785656.

Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease

Chuanxi Tang, Mengting Liu, Zihang Zhou, Hao Li, Chenglin Yang, Li Yang, Jie Xiang

Int J Mol Sci. 2023 May; 24(9): 7830. Published online 2023 Apr 25. doi: 10.3390/ijms24097830

PMCID:: PMC10178565

Abstract Article PDF–4.7M

Select item 99620887.

FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction

Tao Wang, Mengyuan Yu, Hangzhuo Li, Shuguang Qin, Wujing Ren, Yixuan Ma, Wenyan Bo, Yue Xi, Mengxin Cai, Zhenjun Tian

Int J Mol Sci. 2023 Feb; 24(4): 4159. Published online 2023 Feb 19. doi: 10.3390/ijms24044159

PMCID:: PMC9962088

Abstract Article PDF–3.4M

Select item 99153468.

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

Angela Oranger, Roberta Zerlotin, Cinzia Buccoliero, Lorenzo Sanesi, Giuseppina Storlino, Ernestina Schipani, Kenneth Michael Kozloff, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano

Int J Mol Sci. 2023 Feb; 24(3): 1809. Published online 2023 Jan 17. doi: 10.3390/ijms24031809

PMCID:: PMC9915346

Abstract Article PDF–4.2M

Select item 98919259.

Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction

Mingwei Guo, Jing Yao, Jin Li, Jun Zhang, Dongmei Wang, Hui Zuo, Yi Zhang, Bo Xu, Yinzhao Zhong, Fei Shen, Jian Lu, Shuzhe Ding, Cheng Hu, Lingyan Xu, Junjie Xiao, Xinran Ma

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 391–405. Published online 2022 Dec 12. doi: 10.1002/jcsm.13141

PMCID:: PMC9891925

Abstract Article PDF–4.1M

Select item 979108010.

Central Irisin Signaling Is Required for Normal Timing of Puberty in Female Mice

Caroline Decourt, Maggie C Evans, Megan A Inglis, Greg M Anderson

Endocrinology. 2023 Feb; 164(2): bqac208. Published online 2022 Dec 12. doi: 10.1210/endocr/bqac208

PMCID:: PMC9791080

Abstract Article

Select item 975095411.

Exercise-Linked Skeletal Irisin Ameliorates Diabetes-Associated Osteoporosis by Inhibiting the Oxidative Damage–Dependent miR-150-FNDC5/Pyroptosis Axis

Jyotirmaya Behera, Jessica Ison, Michael J. Voor, Neetu Tyagi

Diabetes. 2022 Dec; 71(12): 2777–2792. Published online 2022 Jul 8. doi: 10.2337/db21-0573

PMCID:: PMC9750954

Abstract Article PDF–144M

Select item 963672612.

Irisin protects against obesity-related chronic kidney disease by regulating perirenal adipose tissue function in obese mice

Fang Han, Chengxia Kan, Di Wu, Zengguang Kuang, Hongwei Song, Youhong Luo, Le Zhang, Ningning Hou, Xiaodong Sun

Lipids Health Dis. 2022; 21: 115. Published online 2022 Nov 5. doi: 10.1186/s12944-022-01727-6

PMCID:: PMC9636726

Abstract Article PDF–3.4M

Select item 923329413.

Irisin Attenuates Pathological Neovascularization in Oxygen-Induced Retinopathy Mice

Jieqiong Zhang, Zhifei Liu, Haoqian Wu, Xi Chen, Qiumei Hu, Xue Li, Linlin Luo, Shiyang Ye, Jian Ye

Invest Ophthalmol Vis Sci. 2022 Jun; 63(6): 21. Published online 2022 Jun 23. doi: 10.1167/iovs.63.6.21

PMCID:: PMC9233294

Abstract Article PDF–9.2M

Select item 892044114.

Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice

Can Hu, Xin Zhang, Min Hu, Teng Teng, Yu‐Pei Yuan, Peng Song, Chun‐Yan Kong, Si‐Chi Xu, Zhen‐Guo Ma, Qi‐Zhu Tang

Aging Cell. 2022 Mar; 21(3): e13556. Published online 2022 Feb 15. doi: 10.1111/acel.13556

PMCID:: PMC8920441

Abstract Article PDF–1.7M

Select item 889203015.

FNDC5/irisin facilitates muscle−adipose−bone connectivity through ubiquitination-dependent activation of runt-related transcriptional factors RUNX1/2

Xinyu He, Yue Hua, Qian Li, Wei Zhu, Yu Pan, Yilin Yang, Xinyang Li, Mengxiao Wu, Jiyong Wang, Xiaoqing Gan

J Biol Chem. 2022 Mar; 298(3): 101679. Published online 2022 Feb 4. doi: 10.1016/j.jbc.2022.101679

PMCID:: PMC8892030

Abstract Article PDF–5.9M

Select item 881865016.

Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice

Naoyuki Kawao, Miku Kawaguchi, Takashi Ohira, Hiroki Ehara, Yuya Mizukami, Yoshimasa Takafuji, Hiroshi Kaji

J Cachexia Sarcopenia Muscle. 2022 Feb; 13(1): 758–771. Published online 2022 Jan 7. doi: 10.1002/jcsm.12892

PMCID:: PMC8818650

Abstract Article PDF–10M

Select item 874185317.

Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice

Yuan Xue, Sihan Hu, Chichi Chen, Jiachen He, Jie Sun, Yesheng Jin, Yuanshu Zhang, Guoqing Zhu, Qin Shi, Yongjun Rui

Int J Biol Sci. 2022; 18(2): 572–584. Published online 2022 Jan 1. doi: 10.7150/ijbs.63505

PMCID:: PMC8741853

Abstract Article PDF–3.0M

Select item 869927918.

Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2

Weiwei Zhu, Namood E Sahar, Hafiz Muhammad Ahmad Javaid, Eun Seon Pak, Guang Liang, Yi Wang, Hunjoo Ha, Joo Young Huh

Cells. 2021 Dec; 10(12): 3306. Published online 2021 Nov 25. doi: 10.3390/cells10123306

PMCID:: PMC8699279

Abstract Article PDF–3.4M

Select item 850971819.

Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis

Xiangfen Li, Xiaofang Zhu, Hongle Wu, Thomas E. Van Dyke, Xiaoyang Xu, Elise F. Morgan, Wenyu Fu, Chuanju Liu, Qisheng Tu, Dingming Huang, Jake Chen

Front Cell Dev Biol. 2021; 9: 703670. Published online 2021 Sep 28. doi: 10.3389/fcell.2021.703670

PMCID:: PMC8509718

Abstract Article PDF–3.6M

Select item 850613520.

Irisin levels in the serum and cerebrospinal fluid of patients with multiple sclerosis and the expression and distribution of irisin in experimental autoimmune encephalomyelitis

Qiu‐Xia Zhang, Sheng‐Nan Zhang, Lin‐Jie Zhang, Da‐Qi Zhang, Li Yang

Clin Exp Immunol. 2021 Nov; 206(2): 208–215. Published online 2021 Sep 15. doi: 10.1111/cei.13656

PMCID:: PMC8506135

Abstract Article PDF–728K

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