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Items: 1 to 20 of 64

1.
LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel
Maryline Beurg, Evan Travis Schwalbach, Robert Fettiplace
Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3): e2318270121. Published online 2024 Jan 9. doi: 10.1073/pnas.2318270121
PMCID:
PMC10801851
AbstractArticlePDF–2.3M
2.
The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells
Soichiro Yamaguchi, Maho Kamino, Maho Hamamura, Ken-ichi Otsuguro
PLoS One. 2023; 18(6): e0287249. Published online 2023 Jun 23. doi: 10.1371/journal.pone.0287249
PMCID:
PMC10289374
AbstractArticlePDF–3.3M
3.
Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system
Michelle M Frank, Austen A Sitko, Kirupa Suthakar, Lester Torres Cadenas, Mackenzie Hunt, Mary Caroline Yuk, Catherine JC Weisz, Lisa V Goodrich
eLife. 2023; 12: e83855. Published online 2023 Mar 6. doi: 10.7554/eLife.83855
PMCID:
PMC10147377
AbstractArticlePDF–24M
4.
The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells
Robert Fettiplace, David N. Furness, Maryline Beurg
Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2210849119. Published online 2022 Oct 3. doi: 10.1073/pnas.2210849119
PMCID:
PMC9564823
AbstractArticlePDF–2.0M
5.
Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing
Angela Ballesteros, Kenton J. Swartz
Sci Adv. 2022 Aug; 8(31): eabm5550. Published online 2022 Aug 3. doi: 10.1126/sciadv.abm5550
PMCID:
PMC9348795
AbstractArticlePDF–20M
6.
Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11
Irina Marcovich, Nicholas K. Baer, Olga Shubina-Oleinik, Rachel Eclov, Clayton W. Beard, Jeffrey R. Holt
Biomolecules. 2022 Jul; 12(7): 914. Published online 2022 Jun 29. doi: 10.3390/biom12070914
PMCID:
PMC9313133
AbstractArticlePDF–5.3M
7.
Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices
Nurunisa Akyuz, K. Domenica Karavitaki, Bifeng Pan, Panos I. Tamvakologos, Kelly P. Brock, Yaqiao Li, Debora S. Marks, David P. Corey
Sci Adv. 2022 Jul; 8(28): eabo1126. Published online 2022 Jul 13. doi: 10.1126/sciadv.abo1126
PMCID:
PMC9278870
AbstractArticlePDF–2.6M
8.
Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
John Lee, Kosuke Kawai, Jeffrey R Holt, Gwenaëlle SG Géléoc
eLife. 2021; 10: e69433. Published online 2021 Nov 4. doi: 10.7554/eLife.69433
PMCID:
PMC8598158
AbstractArticlePDF–5.0M
9.
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis
Maryline Beurg, Jong-Hoon Nam, Robert Fettiplace
J Gen Physiol. 2021 Oct 4; 153(10): e202112959. Published online 2021 Aug 19. doi: 10.1085/jgp.202112959
PMCID:
PMC8383808
AbstractArticlePDF–3.2M
10.
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells
Xiaoping Liang, Xufeng Qiu, Gilman Dionne, Christopher L. Cunningham, Michele L. Pucak, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Lawrence Shapiro, Ulrich Müller
Neuron. Author manuscript; available in PMC 2022 Jul 7.
Published in final edited form as: Neuron. 2021 Jul 7; 109(13): 2131–2149.e15. Published online 2021 Jun 5. doi: 10.1016/j.neuron.2021.05.007
PMCID:
PMC8374959
AbstractArticlePDF–3.9M
11.
PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice
Jie Li, Shuang Liu, Chenmeng Song, Qun Hu, Zhikai Zhao, Tuantuan Deng, Yi Wang, Tong Zhu, Linzhi Zou, Shufeng Wang, Jiaofeng Chen, Lian Liu, Hanqing Hou, Kexin Yuan, Hairong Zheng, Zhiyong Liu, Xiaowei Chen, Wenzhi Sun, Bailong Xiao, Wei Xiong
Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28): e2101207118. Published online 2021 Jul 8. doi: 10.1073/pnas.2101207118
PMCID:
PMC8285978
AbstractArticlePDF–1.5M
12.
New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells
Maryline Beurg, Lisa A. Schimmenti, Alaa Koleilat, Sami S. Amr, Andrea Oza, Amanda J. Barlow, Angela Ballesteros, Robert Fettiplace
J Neurosci. 2021 May 19; 41(20): 4378–4391. doi: 10.1523/JNEUROSCI.2537-20.2021
PMCID:
PMC8152607
AbstractArticlePDF–4.6M
13.
Alternative Splicing of Three Genes Encoding Mechanotransduction-Complex Proteins in Auditory Hair Cells
Zijing Zhou, Xiaojie Yu, Biaobin Jiang, Wanying Feng, Ye Tian, Zhiyong Liu, Jiguang Wang, Pingbo Huang
eNeuro. 2021 Jan-Feb; 8(1): ENEURO.0381-20.2020. Prepublished online 2021 Jan 28. Published online 2021 Feb 23. doi: 10.1523/ENEURO.0381-20.2020
PMCID:
PMC7920537
AbstractArticlePDF–2.4M
14.
Early peripheral activity alters nascent subplate circuits in the auditory cortex
Xiangying Meng, Didhiti Mukherjee, Joseph P. Y. Kao, Patrick O. Kanold
Sci Adv. 2021 Feb; 7(7): eabc9155. Published online 2021 Feb 12. doi: 10.1126/sciadv.abc9155
PMCID:
PMC7880598
AbstractArticlePDF–4.2M
15.
A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (mTMC1) Is Translated from a Splice Variant mTmc1ex1 but Not from the Other Variant mTmc1ex2
Soichiro Yamaguchi, Maho Hamamura, Ken-ichi Otsuguro
Int J Mol Sci. 2020 Sep; 21(18): 6465. Published online 2020 Sep 4. doi: 10.3390/ijms21186465
PMCID:
PMC7554986
AbstractArticlePDF–2.8M
16.
TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells
Christopher L. Cunningham, Xufeng Qiu, Zizhen Wu, Bo Zhao, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Ulrich Müller
Neuron. Author manuscript; available in PMC 2021 Jul 8.
Published in final edited form as: Neuron. 2020 Jul 8; 107(1): 126–143.e8. Published online 2020 Apr 27. doi: 10.1016/j.neuron.2020.03.033
PMCID:
PMC7351599
AbstractArticlePDF–3.5M
17.
Tmc gene therapy restores auditory function in deaf mice
Charles Askew, Cylia Rochat, Bifeng Pan, Yukako Asai, Hena Ahmed, Erin Child, Bernard L. Schneider, Patrick Aebischer, Jeffrey R. Holt
Sci Transl Med. Author manuscript; available in PMC 2020 Jun 17.
Published in final edited form as: Sci Transl Med. 2015 Jul 8; 7(295): 295ra108. doi: 10.1126/scitranslmed.aab1996
PMCID:
PMC7298700
AbstractArticlePDF–1.0M
18.
Mechanotransduction dependent control of stereocilia dimensions and row identity in inner hair cells
Jocelyn F. Krey, Paroma Chatterjee, Rachel A. Dumont, Mary O’Sullivan, Dongseok Choi, Jonathan E. Bird, Peter G. Barr-Gillespie
Curr Biol. Author manuscript; available in PMC 2021 Feb 3.
Published in final edited form as: Curr Biol. 2020 Feb 3; 30(3): 442–454.e7. Published online 2020 Jan 2. doi: 10.1016/j.cub.2019.11.076
PMCID:
PMC7002276
AbstractArticlePDF–4.1M
19.
The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells
Adam C. Goldring, Maryline Beurg, Robert Fettiplace
J Physiol. 2019 Dec 15; 597(24): 5949–5961. Published online 2019 Nov 12. doi: 10.1113/JP278799
PMCID:
PMC6910908
AbstractArticlePDF–1.8M
20.
TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice
Shuang Liu, Shufeng Wang, Linzhi Zou, Jie Li, Chenmeng Song, Jiaofeng Chen, Qun Hu, Lian Liu, Pingbo Huang, Wei Xiong
eLife. 2019; 8: e47441. Published online 2019 Oct 29. doi: 10.7554/eLife.47441
PMCID:
PMC6853638
AbstractArticlePDF–2.8M

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