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Select item 113159801.

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

Sarka Janusova, Darina Paprckova, Juraj Michalik, Valeria Uleri, Ales Drobek, Eva Salyova, Louise Chorfi, Ales Neuwirth, Arina Andreyeva, Jan Prochazka, Radislav Sedlacek, Peter Draber, Ondrej Stepanek

EMBO Rep. 2024 Aug; 25(8): 3456–3485. Published online 2024 Jun 14. doi: 10.1038/s44319-024-00179-6

PMCID:: PMC11315980

Abstract Article PDF–5.7M

Select item 112614502.

Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development

Christiane Grammer, Julia A. Komorowska, Jeremy B. Swann

iScience. 2024 Jul 19; 27(7): 110258. Published online 2024 Jun 13. doi: 10.1016/j.isci.2024.110258

PMCID:: PMC11261450

Abstract Article PDF–11M

Select item 107897423.

ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function

Yue Zhu, Qinqin Wang, Xinyu Xie, Cuihong Ma, Yuemei Qiao, Yu Zhang, Yanjun Wu, Yuan Gao, Jing Jiang, Xin Liu, Jianfeng Chen, Chen Li, Gaoxiang Ge

Cell Death Dis. 2024 Jan; 15(1): 55. Published online 2024 Jan 15. doi: 10.1038/s41419-024-06441-y

PMCID:: PMC10789742

Abstract Article PDF–8.7M

Select item 107882274.

Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition

Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma

iScience. 2024 Jan 19; 27(1): 108646. Published online 2023 Dec 9. doi: 10.1016/j.isci.2023.108646

PMCID:: PMC10788227

Abstract Article PDF–5.0M

Select item 98393645.

Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

Anastasia du Halgouet, Aurélie Darbois, Mansour Alkobtawi, Martin Mestdagh, Aurélia Alphonse, Virginie Premel, Thomas Yvorra, Ludovic Colombeau, Raphaël Rodriguez, Dietmar Zaiss, Yara El Morr, Hélène Bugaut, François Legoux, Laetitia Perrin, Selim Aractingi, Rachel Golub, Olivier Lantz, Marion Salou

Immunity. 2023 Jan 10; 56(1): 78–92.e6. doi: 10.1016/j.immuni.2022.12.004

PMCID:: PMC9839364

Abstract Article

Select item 98105336.

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek

Nat Immunol. 2023; 24(1): 174–185. Published online 2022 Dec 23. doi: 10.1038/s41590-022-01366-0

PMCID:: PMC9810533

Abstract Article PDF–6.1M

Select item 97676767.

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel, Lulu Liu, Qurrat Ul Ain, Vincent Ehreiser, Christian Weber, Badr Kilani, Pontus Mertsch, Jeremias Götschke, Sophie Cremer, Wenwen Fu, Michael Lorenz, Hellen Ishikawa-Ankerhold, Elisabeth Raatz, Shaza El-Nemr, Agnes Görlach, Esther Marhuenda, Konstantin Stark, Joachim Pircher, David Stegner, Christian Gieger, Marc Schmidt-Supprian, Florian Gaertner, Isaac Almendros, Malte Kelm, Christian Schulz, Andrés Hidalgo, Steffen Massberg

Immunity. 2022 Dec 13; 55(12): 2285–2299.e7. doi: 10.1016/j.immuni.2022.10.001

PMCID:: PMC9767676

Abstract Article

Select item 95127578.

The changing landscape of immune cells in the fetal mouse testis

Samira Hosseini, Sarah C. Moody, Daniela Fietz, Sivanjah Indumathy, Hans-Christian Schuppe, Mark P. Hedger, Kate L. Loveland

Histochem Cell Biol. 2022; 158(4): 345–368. Published online 2022 Jul 12. doi: 10.1007/s00418-022-02129-6

PMCID:: PMC9512757

Abstract Article PDF–16M

Select item 94890439.

Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance

Ningbo Zheng, Jing Fang, Gang Xue, Ziyu Wang, Xiaoyin Li, Mengshi Zhou, Guangxu Jin, Masmudur M. Rahman, Grant McFadden, Yong Lu

Cancer Cell. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 973–985.e7. Published online 2022 Aug 25. doi: 10.1016/j.ccell.2022.08.001

PMCID:: PMC9489043

Abstract Article PDF–3.1M

Select item 929577010.

A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength

Elena R. Bovolenta, Eva M. García-Cuesta, Lydia Horndler, Julia Ponomarenko, Wolfgang W. Schamel, Mario Mellado, Mario Castro, David Abia, Hisse M. van Santen

Proc Natl Acad Sci U S A. 2022 May 31; 119(22): e2201907119. Published online 2022 May 26. doi: 10.1073/pnas.2201907119

PMCID:: PMC9295770

Abstract Article PDF–1.6M

Select item 900845011.

Mutation of the Polyproline Sequence in CD3ε Evidences TCR Signaling Requirements for Differentiation and Function of Pro-Inflammatory Tγδ17 Cells

Aldo Borroto, Balbino Alarcón, María N. Navarro

Front Immunol. 2022; 13: 799919. Published online 2022 Mar 31. doi: 10.3389/fimmu.2022.799919

PMCID:: PMC9008450

Abstract Article PDF–5.4M

Select item 898720712.

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

Diogo F. T. Veiga, Mathieu Tremblay, Bastien Gerby, Sabine Herblot, André Haman, Patrick Gendron, Sébastien Lemieux, Juan Carlos Zúñiga-Pflücker, Josée Hébert, Joseph Paul Cohen, Trang Hoang

Front Immunol. 2022; 13: 867443. Published online 2022 Mar 24. doi: 10.3389/fimmu.2022.867443

PMCID:: PMC8987207

Abstract Article PDF–8.9M

Select item 889434213.

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Sci Rep. 2022; 12: 3530. Published online 2022 Mar 3. doi: 10.1038/s41598-022-06953-7

PMCID:: PMC8894342

Abstract Article PDF–3.8M

Select item 810806714.

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion

Chiara Sardella, Carine Winkler, Laure Quignodon, Jonathan A. Hardman, Barbara Toffoli, Greta Maria Paola Giordano Attianese, Jennifer E. Hundt, Liliane Michalik, Charles R. Vinson, Ralf Paus, Béatrice Desvergne, Federica Gilardi

J Invest Dermatol. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: J Invest Dermatol. 2018 Mar; 138(3): 500–510. Published online 2017 Sep 28. doi: 10.1016/j.jid.2017.09.024

PMCID:: PMC8108067

Abstract Article PDF–2.4M

Select item 802067515.

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

Emilie Ronin, Charlotte Pouchy, Maryam Khosravi, Morgane Hilaire, Sylvie Grégoire, Armanda Casrouge, Sahar Kassem, David Sleurs, Gaëlle H. Martin, Noémie Chanson, Yannis Lombardi, Guilhem Lalle, Harald Wajant, Cédric Auffray, Bruno Lucas, Gilles Marodon, Yenkel Grinberg-Bleyer, Benoît L. Salomon

Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13): e2014043118. Published online 2021 Mar 25. doi: 10.1073/pnas.2014043118

PMCID:: PMC8020675

Abstract Article PDF–1.3M

Select item 797299316.

Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen

Viola L. Boccasavia, Elena R. Bovolenta, Ana Villanueva, Aldo Borroto, Clara L. Oeste, Hisse M. van Santen, Cristina Prieto, Diego Alonso-López, Manuel D. Diaz-Muñoz, Facundo D. Batista, Balbino Alarcón

Cell Rep. 2021 Mar 16; 34(11): 108861. Published online 2021 Mar 16. doi: 10.1016/j.celrep.2021.108861

PMCID:: PMC7972993

Abstract Article

Select item 790742917.

T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way

Priscillia Bresler, Emmanuel Tejerina, Jean Marie Jacob, Agnès Legrand, Véronique Quellec, Sophie Ezine, Lucie Peduto, Marie Cherrier

iScience. 2021 Mar 19; 24(3): 102158. Published online 2021 Feb 7. doi: 10.1016/j.isci.2021.102158

PMCID:: PMC7907429

Abstract Article PDF–10M

Select item 788861818.

A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy

Joel Crespo, Yi Ting Koh, Ningjie Hu, Paul A. Moore, Ezio Bonvini, Andrew L. Glasebrook, Andrea P. Martin, Robert J. Benschop

PLoS One. 2021; 16(2): e0245917. Published online 2021 Feb 17. doi: 10.1371/journal.pone.0245917

PMCID:: PMC7888618

Abstract Article PDF–1.9M

Select item 781986119.

Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis

Binhui Zhou, Wenyi Yang, Wushan Li, Le He, Liaoxun Lu, Lichen Zhang, Zhuangzhuang Liu, Ying Wang, Tianzhu Chao, Rong Huang, Yanrong Gu, Tingting Jia, Qiaoli Liu, Shuanghua Tian, Philippe Pierre, Takahiro Maeda, Yinming Liang, Eryan Kong

Front Immunol. 2020; 11: 607442. Published online 2021 Jan 8. doi: 10.3389/fimmu.2020.607442

PMCID:: PMC7819861

Abstract Article PDF–3.0M

Select item 777826620.

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression

Ning Kon, Yang Ou, Shang-Jui Wang, Huan Li, Anil K. Rustgi, Wei Gu

Genes Dev. 2021 Jan 1; 35(1-2): 59–64. doi: 10.1101/gad.340919.120

Correction in:: Genes Dev. 2021 Feb 1; 35(3-4): 300.

PMCID:: PMC7778266

Abstract Article PDF–3.6M

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