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Select item 112376691.

GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB

Xiaoran Chang, Yidi Guo, Qun Zhang, Xuebo Zheng, Xuyuan Cui, Junying Hu, Zhiyuan Zhang, Fan Zhang, Xinping Wang

J Virol. 2024 Jun; 98(6): e00268-24. Published online 2024 May 22. doi: 10.1128/jvi.00268-24

PMCID:: PMC11237669

Abstract Article PDF–4.0M

Select item 103184682.

The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection

Hua Yang, Constanza E. Espada, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Li Wu

J Biol Chem. 2023 Jun; 299(6): 104750. Published online 2023 Apr 24. doi: 10.1016/j.jbc.2023.104750

PMCID:: PMC10318468

Abstract Article PDF–4.9M

Select item 102443833.

IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death

Choong-Sil Lee, Gyuho Hwang, Young Woo Nam, Chi Hyun Hwang, Jaewhan Song

Cell Death Differ. 2023 Jun; 30(6): 1575–1584. Published online 2023 Apr 21. doi: 10.1038/s41418-023-01161-w

PMCID:: PMC10244383

Abstract Article PDF–2.8M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100621306.

Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO

Thomas Phelan, Clara Lawler, Andreas Pichlmair, Mark A. Little, Andrew G. Bowie, Gareth Brady

J Virol. 2023 Mar; 97(3): e00108-23. Published online 2023 Mar 14. doi: 10.1128/jvi.00108-23

PMCID:: PMC10062130

Abstract Article PDF–2.4M

Select item 98434407.

The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism

Anthony A. Stephenson, David J. Taggart, Guozhou Xu, Jason D. Fowler, Hao Wu, Zucai Suo

J Biol Chem. 2023 Jan; 299(1): 102796. Published online 2022 Dec 14. doi: 10.1016/j.jbc.2022.102796

PMCID:: PMC9843440

Abstract Article PDF–1.7M

Select item 97045278.

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401

PMCID:: PMC9704527

Abstract Article PDF–7.7M

Select item 96941149.

Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling

Siddharth Sunilkumar, Allyson L. Toro, Christopher M. McCurry, Ashley M. VanCleave, Shaunaci A. Stevens, William P. Miller, Scot R. Kimball, Michael D. Dennis

J Biol Chem. 2022 Dec; 298(12): 102638. Published online 2022 Oct 26. doi: 10.1016/j.jbc.2022.102638

PMCID:: PMC9694114

Abstract Article PDF–2.0M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 934857611.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 934596112.

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Fubing Li, Huichun Liang, Hua You, Ji Xiao, Houjun Xia, Xi Chen, Maobo Huang, Zhuo Cheng, Chuanyu Yang, Wenjing Liu, Hailin Zhang, Li Zeng, Yingying Wu, Fei Ge, Zhen Li, Wenhui Zhou, Yi Wen, Zhongmei Zhou, Rong Liu, Dewei Jiang, Ni Xie, Bin Liang, Zhenzhen Liu, Yanjie Kong, Ceshi Chen

Signal Transduct Target Ther. 2022; 7: 264. Published online 2022 Aug 3. doi: 10.1038/s41392-022-01057-0

PMCID:: PMC9345961

Abstract Article PDF–6.4M

Select item 917422013.

Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer

Meera Patel, Kathryn A. F. Pennel, Jean A. Quinn, Hannah Hood, David K. Chang, Andrew V. Biankin, Selma Rebus, Antonia K. Roseweir, James H. Park, Paul G. Horgan, Donald C. McMillan, Joanne Edwards

Br J Cancer. 2022 Jun 1; 126(12): 1704–1714. Published online 2022 Feb 16. doi: 10.1038/s41416-022-01729-2

PMCID:: PMC9174220

Abstract Article PDF–7.7M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523515.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 905883616.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 893007817.

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor κB kinase alpha (IKKα)

Wayne Bainter, Vassilios Lougaris, Jacqueline G. Wallace, Yousef Badran, Rodrigo Hoyos-Bachiloglu, Zachary Peters, Hazel Wilkie, Mrinmoy Das, Erin Janssen, Abdallah Beano, Khaoula Ben Farhat, Christy Kam, Luisa Bercich, Paolo Incardona, Vincenzo Villanacci, Maria Pia Bondioni, Antonella Meini, Manuela Baronio, Phammela Abarzua, Silvia Parolini, Giovanna Tabellini, Stefano Maio, Birgitta Schmidt, Jeffrey D. Goldsmith, George Murphy, Georg Hollander, Alessandro Plebani, Janet Chou, Raif S. Geha

Sci Immunol. Author manuscript; available in PMC 2022 Mar 17.

Published in final edited form as: Sci Immunol. 2021 Sep 17; 6(63): eabf6723. Published online 2021 Sep 17. doi: 10.1126/sciimmunol.abf6723