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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 113735992.

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo

Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361

PMCID:: PMC11373599

Abstract Article PDF–11M

Select item 113723663.

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT

Wenchao Zhang, Wei Li, Chi Yin, Chengyao Feng, Binfeng Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Cancer Res. 2024 Sep 4; 84(17): 2873–2887. Published online 2024 Jun 20. doi: 10.1158/0008-5472.CAN-24-0163

PMCID:: PMC11372366

Abstract Article PDF–8.2M

Select item 113159364.

The DNA repair protein DNA-PKcs modulates synaptic plasticity via PSD-95 phosphorylation and stability

Cristiana Mollinari, Alessio Cardinale, Leonardo Lupacchini, Alberto Martire, Valentina Chiodi, Andrea Martinelli, Anna Maria Rinaldi, Massimo Fini, Simonetta Pazzaglia, Maria Rosaria Domenici, Enrico Garaci, Daniela Merlo

EMBO Rep. 2024 Aug; 25(8): 3707–3737. Published online 2024 Jul 31. doi: 10.1038/s44319-024-00198-3

PMCID:: PMC11315936

Abstract Article PDF–8.8M

Select item 113042575.

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA‐PKcs

Chenxin Xu, Guoyu Chen, Bo Yu, Bowen Sun, Yingwen Zhang, Mingda Zhang, Yi Yang, Yichuan Xiao, Shi‐Yuan Cheng, Yanxin Li, Haizhong Feng

Adv Sci (Weinh) 2024 Aug; 11(29): 2400023. Published online 2024 Jun 3. doi: 10.1002/advs.202400023

PMCID:: PMC11304257

Abstract Article PDF–8.9M

Select item 112969146.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099357.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111644878.

Targeting PRKDC activates the efficacy of antitumor immunity while sensitizing to chemotherapy and targeted therapy in liver hepatocellular carcinoma

Yitong Pan, Qiyao Zhu, Ting Hong, Jun Cheng, Xinhui Tang

Aging (Albany NY) 2024 May 30; 16(10): 9047–9071. Published online 2024 May 22. doi: 10.18632/aging.205855

PMCID:: PMC11164487

Abstract Article PDF–5.5M

Select item 111601639.

Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

Satoru Shintani, Mariko Mihara, Chunnan Li, Yuuji Nakahara, Satoshi Hino, Koh‐ichi Nakashiro, Hiroyuki Hamakawa

Cancer Sci. 2003 Oct; 94(10): 894–900. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01372.x

PMCID:: PMC11160163

Abstract Article PDF–1.8M

Select item 1110996410.

DNA-PKcs suppresses illegitimate chromosome rearrangements

Jinglong Wang, Cheyenne A Sadeghi, Richard L Frock

Nucleic Acids Res. 2024 May 22; 52(9): 5048–5066. Published online 2024 Feb 27. doi: 10.1093/nar/gkae140

PMCID:: PMC11109964

Abstract Article PDF–2.9M

Select item 1110538611.

IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer

Hasanthi C. de Silva, Mike Z. Lin, Leo Phillips, Janet L. Martin, Robert C. Baxter

Cell Mol Life Sci. 2019 May; 76(10): 2015–2030. Published online 2019 Feb 6. doi: 10.1007/s00018-019-03033-4

PMCID:: PMC11105386

Abstract Article PDF–7.3M

Select item 1108444012.

PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer

Wenqing Luan, Hongyan Cheng, Haoling Xie, Huiping Liu, Yicheng Wang, Shang Wang, Xue Ye, Honglan Zhu, Fuchou Tang, Yi Li, Xiaohong Chang

Int J Mol Sci. 2024 May; 25(9): 4825. Published online 2024 Apr 28. doi: 10.3390/ijms25094825

PMCID:: PMC11084440

Abstract Article PDF–12M

Select item 1107707113.

DNA-PK controls Apollo’s access to leading-end telomeres

Ceylan Sonmez, Beatrice Toia, Patrik Eickhoff, Andreea Medeea Matei, Michael El Beyrouthy, Björn Wallner, Max E Douglas, Titia de Lange, Francisca Lottersberger

Nucleic Acids Res. 2024 May 8; 52(8): 4313–4327. Published online 2024 Feb 26. doi: 10.1093/nar/gkae105

PMCID:: PMC11077071

Abstract Article PDF–2.6M

Select item 1091932914.

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

Zhengping Shao, Ryan A. Flynn, Jennifer L. Crowe, Yimeng Zhu, Jialiang Liang, Wenxia Jiang, Fardin Aryan, Patrick Aoude, Carolyn R. Bertozzi, Verna M. Estes, Brian J. Lee, Govind Bhagat, Shan Zha, Eliezer Calo

Nature. Author manuscript; available in PMC 2024 Mar 7.

Published in final edited form as: Nature. 2020 Mar; 579(7798): 291–296. Published online 2020 Feb 26. doi: 10.1038/s41586-020-2041-2

PMCID:: PMC10919329

Abstract Article PDF–5.4M

Select item 1068833715.

SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption

Muhannad Alruwaili, Stuart Armstrong, Tessa Prince, Maximillian Erdmann, David A. Matthews, Lisa Luu, Andrew Davidson, Waleed Aljabr, Julian A. Hiscox

J Virol. 2023 Nov; 97(11): e00424-23. Published online 2023 Nov 6. doi: 10.1128/jvi.00424-23

PMCID:: PMC10688337

Abstract Article PDF–2.2M

Select item 1052749316.

Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4⁺ helper and CD8⁺ effector T cells

Ana C Azevedo-Pouly, Lauren E Appell, Lyle Burdine, Lora J Rogers, Lauren C Morehead, Daniel Fil, Melanie Barker, Randall R Rainwater, Zachary J Waldrip, Brian Koss, Marie Schluterman Burdine

Immunol Cell Biol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Immunol Cell Biol. 2023 Aug; 101(7): 663–671. Published online 2023 May 6. doi: 10.1111/imcb.12651

PMCID:: PMC10527493

Abstract Article PDF–1006K

Select item 1050093817.

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes

Juli Liu, Shiyong Wu, Yucheng Zhang, Cheng Wang, Sheng Liu, Jun Wan, Lei Yang

Stem Cell Res Ther. 2023; 14: 249. Published online 2023 Sep 13. doi: 10.1186/s13287-023-03485-3

PMCID:: PMC10500938

Abstract Article PDF–5.0M

Select item 1049843618.

FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts

Bin Li, Zuo Ding, Ozlem Calbay, Yue Li, Tao Li, Lingtao Jin, Shuang Huang

Cancer Gene Ther. Author manuscript; available in PMC 2023 Sep 13.

Published in final edited form as: Cancer Gene Ther. 2023 Apr; 30(4): 608–621. Published online 2022 Dec 9. doi: 10.1038/s41417-022-00575-x

PMCID:: PMC10498436

Abstract Article PDF–3.1M

Select item 1048053519.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 1046073220.

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4

Wenhu Chen, Liqiang Hu, Xuemei Lu, Xiaofei Wang, Changan Zhao, Chen Guo, Xiaoyan Li, Yuqin Ding, Hongguang Zhao, Dongdong Tong, Lifang Wang, Chen Huang

Breast Cancer Res Treat. 2023; 201(3): 353–366. Published online 2023 Jul 11. doi: 10.1007/s10549-023-07028-5

PMCID:: PMC10460732

Abstract Article PDF–5.6M

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